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anti-PABPC1 antibody :: Rabbit PABPC1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS125594
Western Blot (WB)
Unit / Price
  DISCONTINUED
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 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

PABPC1, Polyclonal Antibody

 Also Known As   

PABPC1 Polyclonal Antibody

 Product Synonym Names    PABP1: PAB1; PABP; PABP1; PABPC2; PABPL1
 Product Gene Name   

anti-PABPC1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    604679
 3D Structure    ModBase 3D Structure for P11940
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Affinity Purification
 Concentration    1mg/ml (lot specific)
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 Species    Human
 Immunogen    Recombinant Protein
 Immunogen    Recombinant protein of human PABPC1
 Calculated Molecular Weight    71kDa
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 Preparation and Storage    Store at -20 degree C (regular) or -80 degree C (long term). Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
 Other Notes    Small volumes of anti-PABPC1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-PABPC1 antibody

   The poly(A)-binding protein (PABP), which is found complexed to the 3-prime poly(A) tail of eukaryotic mRNA, is required for poly(A) shortening and translation initiation [PMID: 21989405]. Polyadenylate-binding protein 1 (PABPC1) is a cytoplasmic-nuclear shuttling protein important for protein translation initiation, and both RNA processing and stability. In the cytoplasm, PABPC1 binds to the 3' poly(A) tail of eukaryotic mRNAs through its RNA-recognition motifs (RRM) and interacts with the N-terminus of eIF4G, part of the eIF4F complex associated with the 5' cap structure [PMID:20009508, 17381337].
 Product Categories/Family for anti-PABPC1 antibody    Polyclonal
 Applications Tested/Suitable for anti-PABPC1 antibody   

Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FC/FACS)

 Application Notes for anti-PABPC1 antibody    WB: 1:500 - 1:2000
IHC: 1:50 - 1:200
IF: 1:20 - 1:50
FC: 1:20 - 1:50
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 Western Blot (WB) of anti-PABPC1 antibody    Western blot analysis of extracts of Mouse testis, using PABPC1 antibody.
anti-PABPC1 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for PABPC1. It may not necessarily be applicable to this product.
 NCBI GI #    3183544
 NCBI GeneID    26986
 NCBI Accession #    P11940.2 [Other Products]
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 UniProt Primary Accession #    P11940 [Other Products]
 UniProt Secondary Accession #    Q15097; Q93004 [Other Products]
 UniProt Related Accession #    P11940 [Other Products]
 Molecular Weight    636
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 NCBI Official Full Name    Polyadenylate-binding protein 1
 NCBI Official Synonym Full Names    poly(A) binding protein, cytoplasmic 1
 NCBI Official Symbol    PABPC1 [Similar Products]
 NCBI Official Synonym Symbols   
PAB1; PABP; PABP1; PABPC2; PABPL1
[Similar Products]
 NCBI Protein Information    polyadenylate-binding protein 1; poly(A) binding protein, cytoplasmic 2
 UniProt Protein Name    Polyadenylate-binding protein 1
 UniProt Gene Name    PABPC1 [Similar Products]
 UniProt Synonym Gene Names    PAB1; PABP1; PABPC2; PABP-1; Poly(A)-binding protein 1 [Similar Products]
 UniProt Entry Name    PABP1_HUMAN
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 NCBI Summary for PABPC1    This gene encodes a poly(A) binding protein. The protein shuttles between the nucleus and cytoplasm and binds to the 3' poly(A) tail of eukaryotic messenger RNAs via RNA-recognition motifs. The binding of this protein to poly(A) promotes ribosome recruitment and translation initiation; it is also required for poly(A) shortening which is the first step in mRNA decay. The gene is part of a small gene family including three protein-coding genes and several pseudogenes.[provided by RefSeq, Aug 2010]
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 UniProt Comments for PABPC1    PABP 1: poly(A) binding protein 1. May be involved in cytoplasmic regulatory processes of mRNA metabolism. Shuttles between the cytoplasm and the nucleus. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. A potential substrate in MAPKAP kinase 2-induced mRNA stabilization. Two alternatively spliced isoforms have been described.

Protein type: Spliceosome; Translation; Motility/polarity/chemotaxis; RNA splicing; RNA-binding

Chromosomal Location of Human Ortholog: 8q22.2-q23

Cellular Component: focal adhesion; membrane; stress granule; cytoplasm; ribonucleoprotein complex; nucleus; cytosol

Molecular Function: protein C-terminus binding; protein binding; translation activator activity; nucleotide binding; poly(U) binding; poly(A) binding

Biological Process: nuclear mRNA splicing, via spliceosome; poly(A) tail shortening; cellular protein metabolic process; translation; positive regulation of translation; mRNA stabilization; mRNA catabolic process, nonsense-mediated decay; translational initiation; mRNA polyadenylation; gene expression; RNA-mediated gene silencing; mRNA catabolic process, deadenylation-dependent decay
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 Research Articles on PABPC1    1. This study highlights PABP-1 as a protein that is important to the pathology of ALS and indicates that the proteomic profile of TDP-43 inclusions in ALS may differ depending on the causative genetic mutation.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-PABPC1 antibodyPathways associated with anti-PABPC1 antibody
 Reference Product  PubMed Publications
 PAIP2 antibody  >4 publications with PABPC1 and PAIP2
 EIF4E antibody  >2 publications with PABPC1 and EIF4E
 PAIP1 antibody  >2 publications with PABPC1 and PAIP1
 TNRC6A antibody  >1 publications with PABPC1 and TNRC6A
 HNRNPK antibody  >1 publications with PABPC1 and HNRNPK
 Products by Pathway  Pathway Diagram
 AUF1 (hnRNP D0) Destabilizes MRNA Pathway antibodies  AUF1 (hnRNP D0) Destabilizes MRNA Pathway Diagram
 Activation Of The MRNA Upon Binding Of The Cap-binding Complex And EIFs, And Subsequent Binding To 43S Pathway antibodies  Activation Of The MRNA Upon Binding Of The Cap-binding Complex And EIFs, And Subsequent Binding To 43S Pathway Diagram
 Cap-dependent Translation Initiation Pathway antibodies  Cap-dependent Translation Initiation Pathway Diagram
 Deadenylation Of MRNA Pathway antibodies  Deadenylation Of MRNA Pathway Diagram
 Deadenylation-dependent MRNA Decay Pathway antibodies  Deadenylation-dependent MRNA Decay Pathway Diagram
 Eukaryotic Translation Initiation Pathway antibodies  Eukaryotic Translation Initiation Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 L13a-mediated Translational Silencing Of Ceruloplasmin Expression Pathway antibodies  L13a-mediated Translational Silencing Of Ceruloplasmin Expression Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Nonsense Mediated Decay (NMD) Enhanced By The Exon Junction Complex (EJC) Pathway antibodies  Nonsense Mediated Decay (NMD) Enhanced By The Exon Junction Complex (EJC) Pathway Diagram
Diseases associated with anti-PABPC1 antibodyOrgans/Tissues associated with anti-PABPC1 antibody
 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >5 publications with PABPC1 and Carcinoma
 Adenocarcinoma Antibodies  >4 publications with PABPC1 and Adenocarcinoma
 Nervous System Diseases Antibodies  >2 publications with PABPC1 and Nervous System Diseases
 Lung Neoplasms Antibodies  >1 publications with PABPC1 and Lung Neoplasms
 Urinary Bladder Neoplasms Antibodies  >1 publications with PABPC1 and Urinary Bladder Neoplasms
 Brain Diseases Antibodies  >1 publications with PABPC1 and Brain Diseases
 Liver Diseases Antibodies  >1 publications with PABPC1 and Liver Diseases
 Weight Loss Antibodies  >1 publications with PABPC1 and Weight Loss
 Liver Neoplasms Antibodies  >1 publications with PABPC1 and Liver Neoplasms
 Inflammation Antibodies  >1 publications with PABPC1 and Inflammation
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >4 publications with PABPC1 and Liver
 Brain Antibodies  >4 publications with PABPC1 and Brain
 Prostate Antibodies  >3 publications with PABPC1 and Prostate
 Testis Antibodies  >3 publications with PABPC1 and Testis
 Nerve Antibodies  >3 publications with PABPC1 and Nerve
 Muscle Antibodies  >2 publications with PABPC1 and Muscle
 Vascular Antibodies  >2 publications with PABPC1 and Vascular
 Ovary Antibodies  >2 publications with PABPC1 and Ovary
 Bone Antibodies  >1 publications with PABPC1 and Bone
 Blood Antibodies  >1 publications with PABPC1 and Blood
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