NP_001073847.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
parkin coregulated gene protein isoform 2
NCBI Official Synonym Full Names
PARK2 co-regulated
NCBI Protein Information
parkin coregulated gene protein
UniProt Protein Name
Parkin coregulated gene protein
UniProt Synonym Protein Names
Molecular chaperone/chaperonin-binding protein; PARK2 coregulated gene protein
UniProt Synonym Gene Names
UniProt Entry Name
PACRG_HUMAN
NCBI Summary for PACRG
This gene encodes a protein that is conserved across metazoans. In vertebrates, this gene is linked in a head-to-head arrangement with the adjacent parkin gene, which is associated with autosomal recessive juvenile Parkinson's disease. These genes are co-regulated in various tissues and they share a bi-directional promoter. Both genes are associated with susceptibility to leprosy. The parkin co-regulated gene protein forms a large molecular complex with chaperones, including heat shock proteins 70 and 90, and chaperonin components. This protein is also a component of Lewy bodies in Parkinson's disease patients, and it suppresses unfolded Pael receptor-induced neuronal cell death. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for PACRG
PACRG: Suppresses cell death induced by accumulation of unfolded Pael receptor (Pael-R, a substrate of Parkin). Facilitates the formation of inclusions consisting of Pael-R, molecular chaperones, protein degradation molecules and itself when proteasome is inhibited. May play an important role in the formation of Lewy bodies and protection of dopaminergic neurons against Parkinson disease. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Mitochondrial
Chromosomal Location of Human Ortholog: 6q26
Cellular Component: neuron projection; mitochondrion; nucleus; cytosol; vesicle
Molecular Function: G-protein-coupled receptor binding; heat shock protein binding; chaperone binding; ubiquitin protein ligase binding; beta-tubulin binding; Hsp90 protein binding; Hsp70 protein binding; actin binding; alpha-tubulin binding
Biological Process: spermatid development
Disease: Leprosy, Susceptibility To, 2
Product References and Citations for anti-PACRG antibody
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) : Wilson, G.R., et al. Fertil. Steril. 93(7):2262-2268(2010) Dagda, R.K., et al. J. Bioenerg. Biomembr. 41(6):473-479(2009) Velez, D.R., et al. Int. J. Tuberc. Lung Dis. 13(9):1068-1076(2009) Taylor, J.M., et al. Parkinsonism Relat. Disord. 15(6):417-421(2009)
Research Articles on PACRG
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Products associated with anti-PACRG antibody
Diseases associated with anti-PACRG antibody
Organs/Tissues associated with anti-PACRG antibody
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