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anti-GPR37 antibody :: Rabbit PAEL Receptor / GPR37 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS244849
Unit / Price
0.05 mg  /  $530 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

PAEL Receptor / GPR37, Polyclonal Antibody

 Also Known As   

Rabbit Polyclonal to Human PAEL Receptor / GPR37

 Product Synonym Names    Anti-PAEL Receptor / GPR37 Antibody (N-Terminus) IHC-plus; GPR37; EDNRBL; ETBR-LP-1; Gpcr/cns1; HET(B)R-LP; Het-b-r-lp; PAELR; Pael receptor; Human PAEL Receptor; GPR37
 Product Gene Name   

anti-GPR37 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    602583
 3D Structure    ModBase 3D Structure for O15354
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human
Predicted Reactivity: Gorilla, Gibbon, Monkey (at least 90% immunogen sequence identity)
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 Specificity    Human GPR37. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
 Purity/Purification    Immunoaffinity Purified
 Form/Format    PBS, 0.1% sodium azide.
 Concentration    1 mg/ml (lot specific)
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 Target Species    Human
 Immunogen Description    Synthetic 20 amino acid peptide from N-terminal extracellular domain of human GPR37. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey (95%); Marmoset (90%); Rabbit (85%); Panda (80%).
 Immunogen Type    Synthetic peptide
 Immunogen    PAEL Receptor / GPR37 antibody was raised against synthetic 20 amino acid peptide from N-terminal extracellular domain of human GPR37. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey (95%); Marmoset (90%); Rabbit (85%); Panda (80%).
 Antigen Modification    N-Terminus
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 Preparation and Storage    Long term: -70 degree C; Short term: +4 degree C
 Other Notes    Small volumes of anti-GPR37 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-GPR37 antibody

   GPR37 is an Orphan-A GPCR with an unknown ligand. GPR37 was recently identified as the PAEL receptor, a Parkin substrate involved in autosomal recessive juvenile Parkinson's (PDJ) disease. The PAEL receptor becomes unfolded, insoluble, and ubiquitinated when overexpressed, leading to unfolded protein-induced cell death. When the PAEL receptor is ubiquitinated by Parkin, it gets degraded, resulting in the suppression of cell death.
 Product Categories/Family for anti-GPR37 antibody    Family: GPCR
Subfamily: Orphan-A
 Applications Tested/Suitable for anti-GPR37 antibody   

Immunohistochemistry (IHC - Paraffin)

 Application Notes for anti-GPR37 antibody    IHC-P (6 - 11 ug/ml)
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 Immunohistochemistry (IHC) of anti-GPR37 antibody    Anti-PAEL Receptor / GPR37 antibody IHC of human Ovary, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
anti-GPR37 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-GPR37 antibody    Anti-PAEL Receptor / GPR37 antibody IHC of human Pancreas, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
anti-GPR37 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-GPR37 antibody    Anti-GPR37 antibody IHC of human brain, neurons and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
anti-GPR37 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-GPR37 antibody    Anti-PAEL Receptor / GPR37 antibody IHC of human Brain, Glioblastoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
anti-GPR37 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-GPR37 antibody    Anti-PAEL Receptor / GPR37 antibody IHC of human Colon, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
anti-GPR37 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for GPR37. It may not necessarily be applicable to this product.
 NCBI GI #    4885323
 NCBI GeneID    2861
 NCBI Accession #    NP_005293.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_005302.3 [Other Products]
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 UniProt Primary Accession #    O15354 [Other Products]
 UniProt Secondary Accession #    O00348; O14768; Q8TD39; A4D0Y6 [Other Products]
 UniProt Related Accession #    O15354 [Other Products]
 Molecular Weight    67,114 Da
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 NCBI Official Full Name    prosaposin receptor GPR37
 NCBI Official Synonym Full Names    G protein-coupled receptor 37 (endothelin receptor type B-like)
 NCBI Official Symbol    GPR37 [Similar Products]
 NCBI Official Synonym Symbols   
PAELR; EDNRBL; hET(B)R-LP
[Similar Products]
 NCBI Protein Information    prosaposin receptor GPR37; ETBR-LP-1; G-protein coupled receptor 37; endothelin B receptor-like protein 1; probable G-protein coupled receptor 37; Parkin-associated endothelin receptor-like receptor
 UniProt Protein Name    Prosaposin receptor GPR37
 UniProt Synonym Protein Names   
Endothelin B receptor-like protein 1; ETBR-LP-1; G-protein coupled receptor 37; Parkin-associated endothelin receptor-like receptor; PAELR
 Protein Family    Prosaposin receptor
 UniProt Gene Name    GPR37 [Similar Products]
 UniProt Synonym Gene Names    ETBR-LP-1; PAELR [Similar Products]
 UniProt Entry Name    GPR37_HUMAN
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 NCBI Summary for GPR37    This gene is a member of the G protein-coupled receptor family. The encoded protein contains seven transmembrane domains and is found in cell and endoplasmic reticulum membranes. G protein-coupled receptors are involved in translating outside signals into G protein mediated intracellular effects. This gene product interacts with Parkin and is involved in juvenile Parkinson disease. [provided by RefSeq, Oct 2012]
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 UniProt Comments for GPR37    GPR37: Orphan receptor. May have a unique functional role in the central nervous system. Belongs to the G-protein coupled receptor 1 family.

Protein type: Membrane protein, multi-pass; GPCR, family 1; Receptor, GPCR; Membrane protein, integral

Chromosomal Location of Human Ortholog: 7q31

Cellular Component: endoplasmic reticulum membrane; integral to plasma membrane; plasma membrane; ubiquitin ligase complex; receptor complex

Molecular Function: G-protein coupled receptor activity; protein binding; ubiquitin protein ligase binding; heat shock protein binding; peptide receptor activity, G-protein coupled; Hsp70 protein binding; peptide binding

Biological Process: positive regulation of dopamine metabolic process; G-protein coupled receptor protein signaling pathway; positive regulation of MAPKKK cascade; G-protein signaling, adenylate cyclase inhibiting pathway; dopamine biosynthetic process; locomotion during locomotory behavior
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 Research Articles on GPR37    1. Positive role of GPR37 in the proliferation of multiple myeloma cells.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-GPR37 antibodyPathways associated with anti-GPR37 antibody
 Reference Product  PubMed Publications
 PARK2 antibody  >21 publications with GPR37 and PARK2
 SYVN1 antibody  >4 publications with GPR37 and SYVN1
 Products by Pathway  Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies  Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class A Rhodopsin-like Pathway antibodies  GPCRs, Class A Rhodopsin-like Pathway Diagram
 Metabolic Disorders Of Biological Oxidation Enzymes Pathway antibodies  Metabolic Disorders Of Biological Oxidation Enzymes Pathway Diagram
 Parkin-Ubiquitin Proteasomal System Pathway antibodies  Parkin-Ubiquitin Proteasomal System Pathway Diagram
 Parkinson's Disease Pathway antibodies  Parkinson's Disease Pathway Diagram
 Parkinsons Disease Pathway antibodies  Parkinsons Disease Pathway Diagram
 Peptide Ligand-binding Receptors Pathway antibodies  Peptide Ligand-binding Receptors Pathway Diagram
Diseases associated with anti-GPR37 antibodyOrgans/Tissues associated with anti-GPR37 antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >19 publications with GPR37 and Nervous System Diseases
 Nerve Degeneration Antibodies  >3 publications with GPR37 and Nerve Degeneration
 Disease Models, Animal Antibodies  >2 publications with GPR37 and Disease Models, Animal
 Multiple Myeloma Antibodies  >1 publications with GPR37 and Multiple Myeloma
 Atrophy Antibodies  >1 publications with GPR37 and Atrophy
 Liver Diseases Antibodies  >1 publications with GPR37 and Liver Diseases
 Fibrosis Antibodies  >1 publications with GPR37 and Fibrosis
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >26 publications with GPR37 and Brain
 Testis Antibodies  >1 publications with GPR37 and Testis
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