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anti-PLA2G7 antibody :: Rabbit anti-Human PAF Acetylhydrolase Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS415657
Western Blot (WB)
Unit / Price
0.1 mL  /  $205 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

PAF Acetylhydrolase (PLA2G7), Polyclonal Antibody

★Popular Item★
 Also Known As   

PAF Acetylhydrolase Antibody

 Product Synonym Names    PAF Acetylhydrolase
 Product Gene Name   

anti-PLA2G7 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 6; NC_000006.11 (46672053..46703430, complement). Location: 6p21.2-p12
 OMIM    147050
 3D Structure    ModBase 3D Structure for Q13093
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    This Polyclonal antibody is directed against human PAF Acetylhydrolase protein. The product was purified from serum by protein A chromatography. Expect reactivity with human PAF Acetylhydrolase. Cross-reactivity with PAF Acetylhydrolase from other sources has not been determined.
 Purity/Purification    Affinity purified
 Form/Format    Liquid
 Concentration    100ug/100ul (lot specific)
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 Immunogen    Synthetic peptide derived from Human PAF Acetylhydrolase.
 Storage Buffer    PBS, pH 7.4 with 0.02% sodium azide.
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 Preparation and Storage    This product is stable for several weeks at 4 degree C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
 Other Notes    Small volumes of anti-PLA2G7 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-PLA2G7 antibody

   PAF Acetylhydrolase is a Rabbit polyclonal to PAF Acetylhydrolase
 Applications Tested/Suitable for anti-PLA2G7 antibody   

Western Blot (WB)

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 Western Blot (WB) of anti-PLA2G7 antibody    anti-PLA2G7 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for PLA2G7. It may not necessarily be applicable to this product.
 NCBI GI #    270133071
 NCBI GeneID    7941
 NCBI Accession #    NP_001161829.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001168357.1 [Other Products]
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 UniProt Primary Accession #    Q13093 [Other Products]
 UniProt Secondary Accession #    Q15692; Q5VTT1; Q8IVA2; A5HTT5 [Other Products]
 UniProt Related Accession #    Q13093 [Other Products]
 Molecular Weight    50,077 Da [Similar Products]
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 NCBI Official Full Name    platelet-activating factor acetylhydrolase
 NCBI Official Synonym Full Names    phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
 NCBI Official Symbol    PLA2G7 [Similar Products]
 NCBI Official Synonym Symbols   
PAFAD; PAFAH; LP-PLA2; LDL-PLA2
[Similar Products]
 NCBI Protein Information    platelet-activating factor acetylhydrolase; LDL-PLA(2); gVIIA-PLA2; PAF 2-acylhydrolase; PAF acetylhydrolase; group-VIIA phospholipase A2; LDL-associated phospholipase A2; lipoprotein-associated phospholipase A2; 1-alkyl-2-acetylglycerophosphocholine esterase; 2-acetyl-1-alkylglycerophosphocholine esterase
 UniProt Protein Name    Platelet-activating factor acetylhydrolase
 UniProt Synonym Protein Names   
1-alkyl-2-acetylglycerophosphocholine esterase; 2-acetyl-1-alkylglycerophosphocholine esterase; Group-VIIA phospholipase A2; gVIIA-PLA2; LDL-associated phospholipase A2; LDL-PLA(2); PAF 2-acylhydrolase
 Protein Family    Platelet-activating factor acetylhydrolase
 UniProt Gene Name    PLA2G7 [Similar Products]
 UniProt Synonym Gene Names    PAFAH; PAF acetylhydrolase; gVIIA-PLA2; LDL-PLA(2) [Similar Products]
 UniProt Entry Name    PAFA_HUMAN
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 NCBI Summary for PLA2G7    The protein encoded by this gene is a secreted enzyme that catalyzes the degradation of platelet-activating factor to biologically inactive products. Defects in this gene are a cause of platelet-activating factor acetylhydrolase deficiency. Two transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Dec 2009]
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 UniProt Comments for PLA2G7    Function: Modulates the action of platelet-activating factor (PAF) by hydrolyzing the sn-2 ester bond to yield the biologically inactive lyso-PAF. Has a specificity for substrates with a short residue at the sn-2 position. It is inactive against long-chain phospholipids.

Catalytic activity: 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-alkyl-sn-glycero-3-phosphocholine + acetate.

Subcellular location: Secreted › extracellular space.

Tissue specificity: Plasma.

Involvement in disease: Platelet-activating factor acetylhydrolase deficiency (PAFAD) [MIM:614278]: An enzymatic deficiency that results in exacerbated bodily response to inflammatory agents. It can be associated with several disease states including inflammatory gastrointestinal disorders, asthma and atopy. Asthmatic individuals with PAFAD may manifest aggravated respiratory symptoms.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.10 Ref.11 Ref.12 Ref.13 Ref.14Asthma (ASTHMA) [MIM:600807]: The most common chronic disease affecting children and young adults. It is a complex genetic disorder with a heterogeneous phenotype, largely attributed to the interactions among many genes and between these genes and the environment. It is characterized by recurrent attacks of paroxysmal dyspnea, with wheezing due to spasmodic contraction of the bronchi.Note: Disease susceptibility is associated with variations affecting the gene represented in this entry. Ref.15Atopic hypersensitivity (ATOPY) [MIM:147050]: A condition characterized by predisposition to develop hypersensitivity reactions. Atopic individuals can develop eczema, allergic rhinitis and allergic asthma.Note: Disease susceptibility is associated with variations affecting the gene represented in this entry. Ref.15

Sequence similarities: Belongs to the AB hydrolase superfamily. Lipase family.
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 Research Articles on PLA2G7    1. PLA2G7 expression is elevated in colon tumors compared with normal tissues.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-PLA2G7 antibodyPathways associated with anti-PLA2G7 antibody
 Reference Product  PubMed Publications
 PLA2G4A antibody  >1 publications with PLA2G7 and PLA2G4A
 PLA2G6 antibody  >1 publications with PLA2G7 and PLA2G6
 PLA2G2D antibody  >1 publications with PLA2G7 and PLA2G2D
 PLA2G2A antibody  >1 publications with PLA2G7 and PLA2G2A
 Products by Pathway  Pathway Diagram
 Ether Lipid Metabolism Pathway antibodies  Ether Lipid Metabolism Pathway Diagram
 Ether Lipid Metabolism Pathway antibodies  Ether Lipid Metabolism Pathway Diagram
 Lissencephaly Gene (LIS1) In Neuronal Migration And Development Pathway antibodies  Lissencephaly Gene (LIS1) In Neuronal Migration And Development Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Peptide Hormone Metabolism Pathway antibodies  Peptide Hormone Metabolism Pathway Diagram
 Synthesis, Secretion, And Deacylation Of Ghrelin Pathway antibodies  Synthesis, Secretion, And Deacylation Of Ghrelin Pathway Diagram
Diseases associated with anti-PLA2G7 antibodyOrgans/Tissues associated with anti-PLA2G7 antibody
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >31 publications with PLA2G7 and Cardiovascular Diseases
 Coronary Disease Antibodies  >22 publications with PLA2G7 and Coronary Disease
 Heart Diseases Antibodies  >21 publications with PLA2G7 and Heart Diseases
 Atherosclerosis Antibodies  >19 publications with PLA2G7 and Atherosclerosis
 Arteriosclerosis Antibodies  >15 publications with PLA2G7 and Arteriosclerosis
 Inflammation Antibodies  >13 publications with PLA2G7 and Inflammation
 Neoplasms Antibodies  >7 publications with PLA2G7 and Neoplasms
 Disease Models, Animal Antibodies  >5 publications with PLA2G7 and Disease Models, Animal
 Hypertension Antibodies  >3 publications with PLA2G7 and Hypertension
 Necrosis Antibodies  >3 publications with PLA2G7 and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >28 publications with PLA2G7 and Blood
 Prostate Antibodies  >4 publications with PLA2G7 and Prostate
 Brain Antibodies  >3 publications with PLA2G7 and Brain
 Embryonic Tissue Antibodies  >1 publications with PLA2G7 and Embryonic Tissue
 Bone Antibodies  >1 publications with PLA2G7 and Bone
 Lung Antibodies  >1 publications with PLA2G7 and Lung
 Kidney Antibodies  >1 publications with PLA2G7 and Kidney
 Intestine Antibodies  >1 publications with PLA2G7 and Intestine
 Uncharacterized Tissue Antibodies  >1 publications with PLA2G7 and Uncharacterized Tissue
 Placenta Antibodies  >1 publications with PLA2G7 and Placenta
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