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anti-PAF1 antibody :: Rabbit anti-Human PAF1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS7002771
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

PAF1, Polyclonal Antibody

★Popular Item★
 Also Known As   

PAF1 Antibody

 Product Synonym Names    RNA polymerase II-associated factor 1 homolog; hPAF1; Pancreatic differentiation protein 2; PAF1; PD2
 Product Gene Name   

anti-PAF1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    610506
 3D Structure    ModBase 3D Structure for Q8N7H5
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    >95%,Protein G purified
 Form/Format    Liquid
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 Immunogen    Recombinant human RNA polymerase II-associated factor 1 homolog protein
 Conjugation    Non-conjugated
 Storage Buffer    Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery, aliquot and store at -20 degree C or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-PAF1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-PAF1 antibody

   Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Connects PAF1C with the RNF20/40 E3 ubiquitin-protein ligase complex. Involved in polyadenylation of mRNA precursors. Has oncogenic activity in vivo and in vitro.
 Applications Tested/Suitable for anti-PAF1 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

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 Western Blot (WB) of anti-PAF1 antibody    Western Blot
Positive WB detected in:HepG2 whole cell lysate,Hela whole cell lysate,K562 whole cell lysate,Mouse brain tissue
All lanes: PAF1 antibody at 3.2ug/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 60,56 kDa
Observed band size: 60,48 kDa

anti-PAF1 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-PAF1 antibody    Immunohistochemistry of paraffin-embedded human testicular tissue using MBS7002771 at dilution of 1:100
anti-PAF1 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for PAF1. It may not necessarily be applicable to this product.
 NCBI GI #    378744165
 NCBI GeneID    54623
 NCBI Accession #    NP_001243755.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001256826.1 [Other Products]
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 UniProt Primary Accession #    Q8N7H5 [Other Products]
 UniProt Secondary Accession #    O75239; Q9H166; Q9NUU9; M0QX35 [Other Products]
 UniProt Related Accession #    Q8N7H5 [Other Products]
 Molecular Weight    55,473 Da
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 NCBI Official Full Name    RNA polymerase II-associated factor 1 homolog isoform 2
 NCBI Official Synonym Full Names    PAF1 homolog, Paf1/RNA polymerase II complex component
 NCBI Official Symbol    PAF1 [Similar Products]
 NCBI Official Synonym Symbols   
PD2; F23149_1
[Similar Products]
 NCBI Protein Information    RNA polymerase II-associated factor 1 homolog
 UniProt Protein Name    RNA polymerase II-associated factor 1 homolog
 UniProt Synonym Protein Names   
Pancreatic differentiation protein 2
 Protein Family    Proteasome
 UniProt Gene Name    PAF1 [Similar Products]
 UniProt Synonym Gene Names    PD2; hPAF1 [Similar Products]
 UniProt Entry Name    PAF1_HUMAN
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 NCBI Summary for PAF1    This gene encodes a subunit of the polymerase associated factor (PAF1) complex. The PAF1 complex interacts with RNA polymerase II and plays a role in transcription elongation as well as histone modifications including ubiquitylation and methylation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]
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 UniProt Comments for PAF1    PAF1: Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non- phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of MLL1; it promotes leukemogenesis though association with MLL-rearranged oncoproteins, such as MLL-MLLT3/AF9 and MLL-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Connects PAF1C with the RNF20/40 E3 ubiquitin-protein ligase complex. Involved in polyadenylation of mRNA precursors. Has oncogenic activity in vivo and in vitro. Belongs to the PAF1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription regulation; Tumor suppressor

Chromosomal Location of Human Ortholog: 19q13.1

Cellular Component: cell junction; cytoplasm; membrane; nucleoplasm

Molecular Function: chromatin binding; protein binding

Biological Process: endodermal cell fate commitment; histone H2B ubiquitination; histone monoubiquitination; mRNA polyadenylation; negative regulation of myeloid cell differentiation; negative regulation of transcription from RNA polymerase II promoter; nucleosome positioning; positive regulation of histone methylation; positive regulation of mRNA 3'-end processing; positive regulation of RNA elongation from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter; RNA elongation from RNA polymerase II promoter; stem cell maintenance; Wnt receptor signaling pathway
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 Research Articles on PAF1    1. CNOT4 controls the degradation of chromatin-unbound PAF1 via the 26S proteasome.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-PAF1 antibodyDiseases associated with anti-PAF1 antibody
 Reference Product  PubMed Publications
 CDC73 antibody  >49 publications with PAF1 and CDC73
 RTF1 antibody  >48 publications with PAF1 and RTF1
 CTR9 antibody  >34 publications with PAF1 and CTR9
 LEO1 antibody  >28 publications with PAF1 and LEO1
 SUPT16H antibody  >4 publications with PAF1 and SUPT16H
 SUPT5H antibody  >3 publications with PAF1 and SUPT5H
 SSRP1 antibody  >3 publications with PAF1 and SSRP1
 Disease Name  Pubmed Publications
 Immunologic Deficiency Syndromes Antibodies  >3 publications with PAF1 and Immunologic Deficiency Syndromes
 Inflammation Antibodies  >2 publications with PAF1 and Inflammation
 Disease Models, Animal Antibodies  >1 publications with PAF1 and Disease Models, Animal
 Neurobehavioral Manifestations Antibodies  >1 publications with PAF1 and Neurobehavioral Manifestations
 Liver Diseases Antibodies  >1 publications with PAF1 and Liver Diseases
 Congenital Abnormalities Antibodies  >1 publications with PAF1 and Congenital Abnormalities
 Abnormalities, Multiple Antibodies  >1 publications with PAF1 and Abnormalities, Multiple
 Cognition Disorders Antibodies  >1 publications with PAF1 and Cognition Disorders
Organs/Tissues associated with anti-PAF1 antibody
 Organ/Tissue Name  Pubmed Publications
 Parathyroid Antibodies  >11 publications with PAF1 and Parathyroid
 Blood Antibodies  >8 publications with PAF1 and Blood
 Kidney Antibodies  >5 publications with PAF1 and Kidney
 Heart Antibodies  >5 publications with PAF1 and Heart
 Embryonic Tissue Antibodies  >3 publications with PAF1 and Embryonic Tissue
 Bone Antibodies  >2 publications with PAF1 and Bone
 Muscle Antibodies  >2 publications with PAF1 and Muscle
 Liver Antibodies  >2 publications with PAF1 and Liver
 Intestine Antibodies  >1 publications with PAF1 and Intestine
 Skin Antibodies  >1 publications with PAF1 and Skin
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