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anti-PAICS antibody :: Rabbit anti-Human PAICS Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS7045680
Unit / Price
0.05 mL  /  $120 +1 FREE 8GB USB
0.1 mL  /  $160 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

PAICS, Polyclonal Antibody

★Popular Item★
 Also Known As   

PAICS Antibody

 Product Synonym Names    Multifunctional protein ADE2; Phosphoribosylaminoimidazole-succinocarboxamide synthase; SAICAR synthetase; Phosphoribosylaminoimidazole carboxylase; AIR carboxylase; AIRC; PAICS; ADE2; AIRC; PAIS
 Product Gene Name   

anti-PAICS antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    172439
 3D Structure    ModBase 3D Structure for P22234
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    Antigen Affinity Purified
 Form/Format    Liquid
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 Species    Human
 Immunogen    Recombinant human Multifunctional protein ADE2 protein (C-250AA)
 Conjugate    Non-conjugated
 Buffer    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-16150
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-PAICS antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-PAICS antibody

   cytosol, extracellular exosome, membrane, identical protein binding, phosphoribosylaminoimidazole carboxylase activity, phosphoribosylaminoimidazolesuccinocarboxamide synthase activity, 'de novo' IMP biosynthetic process, adenine biosynthetic process, purine nucleobase biosynthetic process, purine ribonucleoside monophosphate biosynthetic process
 Applications Tested/Suitable for anti-PAICS antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

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 Western Blot (WB) of anti-PAICS antibody    Western blot
All lanes:  PAICSantibody at 3.98ug/ml
Lane 1 : Hela whole cell lysate
Lane 2 : Raji whole cell lysate
Lane 3 : 293T whole cell lysate
Lane 4 : NIH/3T3 whole cell lysate
Secondary
Goat polyclonal to Rabbit IgG at 1/10000 dilution
Predicted band size: 47 kDa
Observed band size: 47 kDa

anti-PAICS antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-PAICS antibody    Immunohistochemistry of paraffin-embedded human liver tissue using MBS7045680 at dilution 1:100
anti-PAICS antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-PAICS antibody    Immunohistochemistry of paraffin-embedded human testis tissue using MBS7045680 at dilution 1:100
anti-PAICS antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for PAICS. It may not necessarily be applicable to this product.
 NCBI GI #    119220557
 NCBI GeneID    10606
 NCBI Accession #    NP_001072992.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001079524.1 [Other Products]
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 UniProt Primary Accession #    P22234 [Other Products]
 UniProt Secondary Accession #    Q68CQ5; E9PDH9 [Other Products]
 UniProt Related Accession #    P22234 [Other Products]
 Molecular Weight    47,958 Da
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 NCBI Official Full Name    multifunctional protein ADE2 isoform 2
 NCBI Official Synonym Full Names    phosphoribosylaminoimidazole carboxylase; phosphoribosylaminoimidazolesuccinocarboxamide synthase
 NCBI Official Symbol    PAICS [Similar Products]
 NCBI Official Synonym Symbols   
ADE2; AIRC; PAIS; ADE2H1
[Similar Products]
 NCBI Protein Information    multifunctional protein ADE2
 UniProt Protein Name    Multifunctional protein ADE2
 UniProt Synonym Protein Names   
Phosphoribosylaminoimidazole-succinocarboxamide synthase (EC:6.3.2.6)Alternative name(s):SAICAR synthetase
 Protein Family    Multifunctional protein
 UniProt Gene Name    PAICS [Similar Products]
 UniProt Synonym Gene Names    ADE2; AIRC; PAIS; AIRC [Similar Products]
 UniProt Entry Name    PUR6_HUMAN
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 NCBI Summary for PAICS    This gene encodes a bifunctional enzyme containing phosphoribosylaminoimidazole carboxylase activity in its N-terminal region and phosphoribosylaminoimidazole succinocarboxamide synthetase in its C-terminal region. It catalyzes steps 6 and 7 of purine biosynthesis. The gene is closely linked and divergently transcribed with a locus that encodes an enzyme in the same pathway, and transcription of the two genes is coordinately regulated. The human genome contains several pseudogenes of this gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for PAICS    PAICS: 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Ligase; EC 4.1.1.21; EC 6.3.2.6; Nucleotide Metabolism - purine; Lyase

Chromosomal Location of Human Ortholog: 4q12

Cellular Component: cytosol; membrane

Molecular Function: identical protein binding; phosphoribosylaminoimidazole carboxylase activity; phosphoribosylaminoimidazolesuccinocarboxamide synthase activity; protein binding

Biological Process: 'de novo' IMP biosynthetic process; adenine biosynthetic process; purine base biosynthetic process; purine ribonucleoside monophosphate biosynthetic process
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 Research Articles on PAICS    1. purine biosynthetic pathway enzymes PPAT and PAICS, as well as pyruvate kinase activity are increased in lung cancer
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-PAICS antibodyDiseases associated with anti-PAICS antibody
 Products by Pathway  Pathway Diagram
 Inosine Monophosphate Biosynthesis, PRPP + Glutamine => IMP Pathway antibodies  Inosine Monophosphate Biosynthesis, PRPP + Glutamine => IMP Pathway Diagram
 Inosine Monophosphate Biosynthesis, PRPP + Glutamine => IMP Pathway antibodies  Inosine Monophosphate Biosynthesis, PRPP + Glutamine => IMP Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Nucleotides Pathway antibodies  Metabolism Of Nucleotides Pathway Diagram
 Purine Metabolism Pathway antibodies  Purine Metabolism Pathway Diagram
 Purine Metabolism Pathway antibodies  Purine Metabolism Pathway Diagram
 Purine Metabolism Pathway antibodies  Purine Metabolism Pathway Diagram
 Purine Ribonucleoside Monophosphate Biosynthesis Pathway antibodies  Purine Ribonucleoside Monophosphate Biosynthesis Pathway Diagram
 Inosine-5'-phosphate Biosynthesis Pathway antibodies  Inosine-5'-phosphate Biosynthesis Pathway Diagram
 Disease Name  Pubmed Publications
 Lung Neoplasms Antibodies  >2 publications with PAICS and Lung Neoplasms
 Neoplasm Invasiveness Antibodies  >1 publications with PAICS and Neoplasm Invasiveness
 Neoplasm Metastasis Antibodies  >1 publications with PAICS and Neoplasm Metastasis
Organs/Tissues associated with anti-PAICS antibody
 Organ/Tissue Name  Pubmed Publications
 Ovary Antibodies  >2 publications with PAICS and Ovary
 Prostate Antibodies  >2 publications with PAICS and Prostate
 Lung Antibodies  >2 publications with PAICS and Lung
 Skin Antibodies  >2 publications with PAICS and Skin
 Muscle Antibodies  >1 publications with PAICS and Muscle
 Blood Antibodies  >1 publications with PAICS and Blood
 Eye Antibodies  >1 publications with PAICS and Eye
 Brain Antibodies  >1 publications with PAICS and Brain
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