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anti-PAK1 antibody :: Rabbit PAK1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS175263
Testing Data
Unit / Price
0.1 mg  /  $245 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

PAK1, Polyclonal Antibody

 Also Known As   

Anti-PAK1 antibody

 Product Synonym Names    Serine/threonine-protein kinase PAK 1; p21 protein(Cdc42/Rac)-activated kinase 1; Alpha PAK antibody; Alpha-PAK antibody; MGC130000 antibody; MGC130001 antibody; p21 activated kinase 1 antibody; p21 protein(Cdc42/Rac) activated kinase 1 antibody; p21-activated kinase 1 antibody; p21/Cdc42/Rac1 activated kinase 1(yeast Ste20 related) antibody; p21/Cdc42/Rac1 activated kinase 1 antibody; p21/Cdc42/Rac1-activated kinase 1(STE20 homolog, yeast) antibody; p65 PAK antibody; p65-PAK antibody; PAK alpha antibody; PAK-1 antibody; Pak1 antibody; PAK1_HUMAN antibody; Paka antibody; PAKalpha antibody; Protein kinase MUK2 antibody; Rac/p21-activated kinase antibody; Serine/threonine-protein kinase PAK 1 antibody; STE20 homolog(yeast) antibody; STE20 homolog yeast antibody
 Product Gene Name   

anti-PAK1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    602590
 3D Structure    ModBase 3D Structure for Q13153
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Immunogen affinity purified.
 Form/Format    Lyophilized
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 Immunogen    A synthetic peptide corresponding to a sequence at the N-terminus of human PAK1 (1-14aa MSNNGLDIQDKPPA), different from the related mouse and rat sequences by on amino acid.
 Contents    Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
 Reconstitution    Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
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 Preparation and Storage    At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-PAK1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-PAK1 antibody

   Description: Rabbit IgG polyclonal antibody for Serine/threonine-protein kinase PAK 1(PAK1) detection. Tested with WB in Human, Mouse, Rat.
Background: Serine/threonine-protein kinase PAK 1 is an enzyme that in humans is encoded by the PAK1 gene. PAK proteins are critical effectors that link RhoGTPases to cytoskeleton reorganization and nuclear signaling. PAK proteins, a family of serine/threonine p21-activated kinases, include PAK1, PAK2, PAK3 and PAK4. These proteins serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK1 regulates cell motility and morphology. Alternative transcripts of this gene have been found, but their full-length natures have not yet been determined. The PAK1 gene is mapped to 11q13-q14 by inclusion within a mapped clone.
 Applications Tested/Suitable for anti-PAK1 antibody   

Western Blot (WB)

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 Testing Data of anti-PAK1 antibody    anti-PAK1 antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for PAK1. It may not necessarily be applicable to this product.
 NCBI GI #    90111767
 NCBI GeneID    5058
 NCBI Accession #    Q13153.2 [Other Products]
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 UniProt Primary Accession #    Q13153 [Other Products]
 UniProt Secondary Accession #    O75561; Q13567; Q32M53; Q32M54; Q86W79 [Other Products]
 UniProt Related Accession #    Q13153 [Other Products]
 Molecular Weight    61,632 Da
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 NCBI Official Full Name    Serine/threonine-protein kinase PAK 1
 NCBI Official Synonym Full Names    p21 protein (Cdc42/Rac)-activated kinase 1
 NCBI Official Symbol    PAK1 [Similar Products]
 NCBI Official Synonym Symbols   
PAKalpha
[Similar Products]
 NCBI Protein Information    serine/threonine-protein kinase PAK 1; p65-PAK; alpha-PAK; STE20 homolog, yeast; p21/Cdc42/Rac1-activated kinase 1 (yeast Ste20-related); p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast)
 UniProt Protein Name    Serine/threonine-protein kinase PAK 1
 UniProt Synonym Protein Names   
Alpha-PAK; p21-activated kinase 1; PAK-1; p65-PAK
 Protein Family    Serine/threonine-protein kinase
 UniProt Gene Name    PAK1 [Similar Products]
 UniProt Synonym Gene Names    PAK-1 [Similar Products]
 UniProt Entry Name    PAK1_HUMAN
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 NCBI Summary for PAK1    This gene encodes a family member of serine/threonine p21-activating kinases, known as PAK proteins. These proteins are critical effectors that link RhoGTPases to cytoskeleton reorganization and nuclear signaling, and they serve as targets for the small GTP binding proteins Cdc42 and Rac. This specific family member regulates cell motility and morphology. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2010]
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 UniProt Comments for PAK1    PAK1: a protein kinase of the STE20 family that regulates cell motility and morphology. Critical RhoGTPase effector that regulates cytoskeleton reorganization, the JNK MAPK pathway, and nuclear signaling. Binding of Rac/cdc42 to the PBD of PAK1 causes autophosphorylation and conformational change. Phosphorylated and activated by PDK.

Protein type: Protein kinase, Ser/Thr (non-receptor); Kinase, protein; EC 2.7.11.1; Protein kinase, STE; STE group; STE20 family; PAKA subfamily

Chromosomal Location of Human Ortholog: 11q13-q14

Cellular Component: Golgi apparatus; nuclear membrane; protein complex; focal adhesion; dendrite; intercellular junction; cytosol; Z disc; ruffle; filamentous actin; growth cone; axon; cytoplasm; plasma membrane

Molecular Function: collagen binding; protein serine/threonine kinase activity; protein binding; protein kinase binding; ATP binding; receptor signaling protein serine/threonine kinase activity; protein kinase activity

Biological Process: positive regulation of JNK activity; axon guidance; exocytosis; wound healing; apoptosis; protein amino acid autophosphorylation; positive regulation of estrogen receptor signaling pathway; receptor clustering; protein amino acid phosphorylation; T cell receptor signaling pathway; positive regulation of stress fiber formation; ephrin receptor signaling pathway; dendrite development; neuromuscular junction development; MAPKKK cascade; positive regulation of peptidyl-serine phosphorylation; branching morphogenesis of a tube; cellular response to insulin stimulus; actin cytoskeleton reorganization; T cell costimulation; response to hypoxia; innate immune response; positive regulation of protein amino acid phosphorylation; mitotic cell cycle; vascular endothelial growth factor receptor signaling pathway; neurite morphogenesis
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 Research Articles on PAK1    1. These findings identify CK2 as an upstream activating kinase of PAK1, providing a novel mechanism for PAK1 activation.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-PAK1 antibodyPathways associated with anti-PAK1 antibody
 Reference Product  PubMed Publications
 CDC42 antibody  >309 publications with PAK1 and CDC42
 RAC1 antibody  >276 publications with PAK1 and RAC1
 LIMK1 antibody  >45 publications with PAK1 and LIMK1
 PAK3 antibody  >39 publications with PAK1 and PAK3
 ARHGEF7 antibody  >12 publications with PAK1 and ARHGEF7
 RAC3 antibody  >7 publications with PAK1 and RAC3
 RHOU antibody  >5 publications with PAK1 and RHOU
 RAF1 antibody  >5 publications with PAK1 and RAF1
 NCK2 antibody  >3 publications with PAK1 and NCK2
 NCK1 antibody  >1 publications with PAK1 and NCK1
 Products by Pathway  Pathway Diagram
 Activation Of Rac Pathway antibodies  Activation Of Rac Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Alpha6-Beta4 Integrin Signaling Pathway antibodies  Alpha6-Beta4 Integrin Signaling Pathway Diagram
 Angiopoietin Receptor Tie2-mediated Signaling Pathway antibodies  Angiopoietin Receptor Tie2-mediated Signaling Pathway Diagram
 Aurora A Signaling Pathway antibodies  Aurora A Signaling Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 CD28 Co-stimulation Pathway antibodies  CD28 Co-stimulation Pathway Diagram
 CD28 Dependent Vav1 Pathway antibodies  CD28 Dependent Vav1 Pathway Diagram
Diseases associated with anti-PAK1 antibodyOrgans/Tissues associated with anti-PAK1 antibody
 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >79 publications with PAK1 and Breast Neoplasms
 Cardiovascular Diseases Antibodies  >37 publications with PAK1 and Cardiovascular Diseases
 Disease Models, Animal Antibodies  >32 publications with PAK1 and Disease Models, Animal
 Adenocarcinoma Antibodies  >32 publications with PAK1 and Adenocarcinoma
 Neoplasms, Experimental Antibodies  >25 publications with PAK1 and Neoplasms, Experimental
 Inflammation Antibodies  >24 publications with PAK1 and Inflammation
 Liver Diseases Antibodies  >18 publications with PAK1 and Liver Diseases
 Liver Neoplasms Antibodies  >18 publications with PAK1 and Liver Neoplasms
 Necrosis Antibodies  >17 publications with PAK1 and Necrosis
 Heart Diseases Antibodies  >17 publications with PAK1 and Heart Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >98 publications with PAK1 and Blood
 Brain Antibodies  >80 publications with PAK1 and Brain
 Muscle Antibodies  >76 publications with PAK1 and Muscle
 Vascular Antibodies  >72 publications with PAK1 and Vascular
 Lung Antibodies  >46 publications with PAK1 and Lung
 Heart Antibodies  >40 publications with PAK1 and Heart
 Kidney Antibodies  >39 publications with PAK1 and Kidney
 Liver Antibodies  >31 publications with PAK1 and Liver
 Embryonic Tissue Antibodies  >24 publications with PAK1 and Embryonic Tissue
 Prostate Antibodies  >22 publications with PAK1 and Prostate
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