NP_071919.1
[Other Products]
NCBI GenBank Nucleotide #
|
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
73,421 Da
NCBI Official Full Name
membrane protein, palmitoylated 5; MAGUK p55 subfamily member 5; stardust (Drosophila)
NCBI Official Synonym Full Names
membrane palmitoylated protein 5
NCBI Official Synonym Symbols
NCBI Protein Information
MAGUK p55 subfamily member 5
UniProt Protein Name
MAGUK p55 subfamily member 5
UniProt Entry Name
MPP5_HUMAN
NCBI Summary for MPP5
This gene encodes a member of the p55-like subfamily of the membrane-associated guanylate kinase (MAGUK) gene superfamily. The encoded protein participates in the polarization of differentiating cells, has been shown to regulate myelinating Schwann cells (PMID: 20237282), and is one of the components of the Crumbs complex in the retina. Mice which express lower levels of the orthologous protein have retinal degeneration and impaired vision (PMID: 22114289). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]
UniProt Comments for MPP5
MPP5: May play a role in tight junctions biogenesis and in the establishment of cell polarity in epithelial cells. May modulate SC6A1/GAT1-mediated GABA uptake by stabilizing the transporter. Required for localization of EZR to the apical membrane of parietal cells and may play a role in the dynamic remodeling of the apical cytoskeleton. Belongs to the MAGUK family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 14q23.3
Cellular Component: cytoplasm; endomembrane system; lateral loop; nucleoplasm; plasma membrane; protein complex; tight junction
Molecular Function: protein binding; protein domain specific binding
Biological Process: morphogenesis of an epithelial sheet; myelin formation; myelin maintenance in the peripheral nervous system
Research Articles on MPP5
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated with anti-MPP5 antibody
Pathways associated with anti-MPP5 antibody
Diseases associated with anti-MPP5 antibody
Organs/Tissues associated with anti-MPP5 antibody
|