NP_683879.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
pantothenate kinase 1 isoform beta
NCBI Official Synonym Full Names
pantothenate kinase 1
NCBI Official Synonym Symbols
NCBI Protein Information
pantothenate kinase 1; pantothenic acid kinase 1
UniProt Protein Name
Pantothenate kinase 1
UniProt Synonym Protein Names
Pantothenic acid kinase 1
UniProt Synonym Gene Names
UniProt Entry Name
PANK1_HUMAN
NCBI Summary for PANK1
This gene encodes a member of the pantothenate kinase family. Pantothenate kinases are key regulatory enzymes in the biosynthesis of coenzyme A (CoA). The encoded protein catalyzes the first and rate-limiting enzymatic reaction in CoA biosynthesis and is regulated by CoA through feedback inhibition. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. This gene and an intronic miRNA on the same strand are co-regulated by the tumor suppressor p53 (see PMID 20833636). [provided by RefSeq, Apr 2011]
UniProt Comments for PANK1
PANK1: Plays a role in the physiological regulation of the intracellular CoA concentration. Belongs to the type II pantothenate kinase family. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 2.7.1.33; Cofactor and Vitamin Metabolism - pantothenate and CoA biosynthesis; Kinase, other
Chromosomal Location of Human Ortholog: 10q23.31
Cellular Component: recycling endosome; clathrin coat; nucleus; cytosol
Molecular Function: pantothenate kinase activity; ATP binding
Biological Process: coenzyme biosynthetic process; coenzyme A biosynthetic process; vitamin metabolic process; pantothenate metabolic process; phosphorylation; water-soluble vitamin metabolic process
Research Articles on PANK1
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Products associated with anti-PANK1 antibody
Pathways associated with anti-PANK1 antibody
Diseases associated with anti-PANK1 antibody
Organs/Tissues associated with anti-PANK1 antibody
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