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anti-PAPD5 antibody :: Rabbit anti-Human PAPD5 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9211826
Western Blot (WB)
Unit / Price
0.08 mL  /  $150 +1 FREE 8GB USB
0.4 mL  /  $340 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

PAPD5, Polyclonal Antibody

★Popular Item★
 Also Known As   

PAPD5 Antibody (N-term)

 Product Synonym Names    Non-canonical poly(A) RNA polymerase PAPD5; PAP-associated domain-containing protein 5; Terminal uridylyltransferase 3; TUTase 3; Topoisomerase-related function protein 4-2; TRF4-2; PAPD5
 Product Gene Name   

anti-PAPD5 antibody

[Similar Products]
 Antibody/Peptide Pairs    PAPD5 peptide (MBS9223443) is used for blocking the activity of PAPD5 antibody (MBS9211826)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence Positions    1-30
 OMIM    605540
 3D Structure    ModBase 3D Structure for Q8NDF8
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 Clonality    Polyclonal
 Isotype    Rabbit Ig
 Clone Number    RB38544
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    This PAPD5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human PAPD5.
 Form/Format    Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
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 Function    Catalytic subunit of a TRAMP-like complex which has a poly(A) RNA polymerase activity and is involved in a post- transcriptional quality control mechanism. Polyadenylation with short oligo(A) tails is required for the degradative activity of the exosome on several of its nuclear RNA substrates. Doesn't need a cofactor for polyadenylation activity (in vitro). Plays a role in replication-dependent histone mRNA degradation, probably through terminal uridylation of mature histone mRNAs. May play a role in sister chromatid cohesion.
 Cellular Location    Nucleus. Nucleus, nucleolus. Cytoplasm. Note=Predominantly expressed in the cytoplasm (PubMed:18172165)
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 Preparation and Storage    Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles
 Other Notes    Small volumes of anti-PAPD5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-PAPD5 antibody

   PAPD5 plays a role in replication-dependent histone mRNA degradation. May be involved in the terminal uridylation of mature histone mRNAs before their degradation is initiated. DNA polymerase, probably involved in DNA repair. May play a role in sister chromatid cohesion.
 Applications Tested/Suitable for anti-PAPD5 antibody   

Western Blot (WB), ELISA (EIA)

 Application Notes for anti-PAPD5 antibody    WB~~1:1000
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 Western Blot (WB) of anti-PAPD5 antibody    PAPD5 Antibody (N-term) western blot analysis in human placenta tissue lysates (35ug/lane).This demonstrates the PAPD5 Antibody detected the PAPD5 protein (arrow).
anti-PAPD5 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for PAPD5. It may not necessarily be applicable to this product.
 NCBI GI #    256818780
 NCBI GeneID    64282
 NCBI Accession #    NP_001035374.2 [Other Products]
 NCBI Related Accession #    NP_001035375.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_001040284.2 [Other Products]
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 UniProt Primary Accession #    Q8NDF8 [Other Products]
 UniProt Secondary Accession #    Q9NW67; Q9Y6C0; B4DV38 [Other Products]
 UniProt Related Accession #    Q8NDF8 [Other Products]
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 NCBI Official Full Name    non-canonical poly(A) RNA polymerase PAPD5 isoform a
 NCBI Official Synonym Full Names    PAP associated domain containing 5
 NCBI Official Symbol    PAPD5 [Similar Products]
 NCBI Official Synonym Symbols   
TRF4-2
[Similar Products]
 NCBI Protein Information    non-canonical poly(A) RNA polymerase PAPD5
 UniProt Protein Name    Non-canonical poly(A) RNA polymerase PAPD5
 UniProt Synonym Protein Names   
PAP-associated domain-containing protein 5; Terminal uridylyltransferase 3; TUTase 3; Topoisomerase-related function protein 4-2; TRF4-2
 Protein Family    Non-canonical poly(A) RNA polymerase
 UniProt Gene Name    PAPD5 [Similar Products]
 UniProt Synonym Gene Names    TUTase 3; TRF4-2 [Similar Products]
 UniProt Entry Name    PAPD5_HUMAN
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 UniProt Comments for PAPD5    PAPD5: Plays a role in replication-dependent histone mRNA degradation. May be involved in the terminal uridylation of mature histone mRNAs before their degradation is initiated. DNA polymerase, probably involved in DNA repair. May play a role in sister chromatid cohesion. Belongs to the DNA polymerase type-B-like family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Transferase; EC 2.7.7.19; Nucleolus

Chromosomal Location of Human Ortholog: 16q12.1

Cellular Component: cytoplasm; nucleolus

Molecular Function: polynucleotide adenylyltransferase activity; DNA binding; metal ion binding; DNA-directed DNA polymerase activity

Biological Process: mitosis; cell division; mRNA processing; rRNA processing
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Product References and Citations for anti-PAPD5 antibody

   Rose, J. Phd, et al. Mol. Med. (2010) In press :
Mullen, T.E., et al. Genes Dev. 22(1):50-65(2008)
Walowsky, C., et al. J. Biol. Chem. 274(11):7302-7308(1999)
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 Research Articles on PAPD5    1. PAPD5 and PARN mediate degradation of oncogenic miRNA miR-21.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-PAPD5 antibodyPathways associated with anti-PAPD5 antibody
 Reference Product  PubMed Publications
 ZCCHC7 antibody  >1 publications with PAPD5 and ZCCHC7
 TUT1 antibody  >1 publications with PAPD5 and TUT1
 MTPAP antibody  >1 publications with PAPD5 and MTPAP
 EXOSC10 antibody  >1 publications with PAPD5 and EXOSC10
 Products by Pathway  Pathway Diagram
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 Vitamin B6 Metabolism Pathway antibodies  Vitamin B6 Metabolism Pathway Diagram
Organs/Tissues associated with anti-PAPD5 antibody
 Organ/Tissue Name  Pubmed Publications
 Embryonic Tissue Antibodies  >1 publications with PAPD5 and Embryonic Tissue
 Kidney Antibodies  >1 publications with PAPD5 and Kidney
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