NP_001015880.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
69,970 Da
NCBI Official Full Name
bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 isoform b
NCBI Official Synonym Full Names
3'-phosphoadenosine 5'-phosphosulfate synthase 2
NCBI Protein Information
bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2
UniProt Protein Name
Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2
UniProt Synonym Protein Names
Sulfurylase kinase 2; SK 2; SK2
UniProt Synonym Gene Names
NCBI Summary for PAPSS2
Sulfation is a common modification of endogenous (lipids, proteins, and carbohydrates) and exogenous (xenobiotics and drugs) compounds. In mammals, the sulfate source is 3'-phosphoadenosine 5'-phosphosulfate (PAPS), created from ATP and inorganic sulfate. Two different tissue isoforms encoded by different genes synthesize PAPS. This gene encodes one of the two PAPS synthetases. Defects in this gene cause the Pakistani type of spondyloepimetaphyseal dysplasia. Two alternatively spliced transcript variants that encode different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for PAPSS2
Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate (PAPS: activated sulfate donor used by sulfotransferase). In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate-activation pathway. May have a important role in skeletogenesis during postnatal growth ().
Research Articles on PAPSS2
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Products associated with anti-PAPSS2 antibody
Pathways associated with anti-PAPSS2 antibody
Diseases associated with anti-PAPSS2 antibody
Organs/Tissues associated with anti-PAPSS2 antibody
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