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anti-PBR antibody :: Rabbit anti-Human, Rat PBR Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS5400187 anti-PBR antibody
Unit / Price
0.1 mg Biotin  /  $495 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

PBR, Polyclonal Antibody

★Popular Item★
 Also Known As   

PBR Antibody BIOTIN-Conjugated

 Product Synonym Names    Benzodiazapine receptor (peripheral); Benzodiazepine peripheral binding site; BPBS; BZRP; DBI; IBP; Isoquinoline carboxamide-binding protein; MBR; mDRC; Mitochondrial benzodiazepine receptor; PBR; PBS; Peripheral benzodiazepine receptor; Peripheral benzodiazepine receptor-related protein; pk18; PKBS; PTBR; Ptbzr; PTBZR02; RATPTBZR02; translocator protein (18kDa); Translocator protein; TSPO; Tspo1 antibody
 Product Gene Name   

anti-PBR antibody

[Similar Products]
 Matching Pairs    Antibody: PBR (MBS5400187)
Positive Control: PBR (MBS543359)
 Antibody/Peptide Pairs    PBR peptide (MBS544627) is used for blocking the activity of PBR antibody (MBS5400187)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    109610
 3D Structure    ModBase 3D Structure for P30536
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human, Rat
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 Form/Format    BIOTIN-Conjugated
 Concentration    0.60-0.65 ug/ul in antibody stabilization buffer (lot specific)
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 Immunogen    Synthetic peptide taken within amino acid region 100-150 on 18 kDa mitochondrial benzodiazepine receptor protein.
 Expression    Found in many tissue types. Expressed at the highest levels under normal conditions in tissues that synthesize steroids
 Molecular Function    Benzodiazepine receptor activity, cholesterol binding
 Subcellular Location    Mitochondrian membrane, Multi-pass membrane protein
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 Preparation and Storage    -20 degree C for long term storage
 Other Notes    Small volumes of anti-PBR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-PBR antibody

   BIOTIN-Conjugated Mitochondrial benzodiazepine receptor Antibody
Can bind protoporphyrin IX and may play a role in transport of porphyrins and heme. Promotes transport of cholesterol across mitochondrial membranes and may play a role in lipid metabolism.
 Applications Tested/Suitable for anti-PBR antibody   

ELISA (EIA), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB)

 Application Notes for anti-PBR antibody    Dot Blot: 1:10,000
ELISA: 1:10,000
Immunohistochemistry: 1:100
Immunoprecipitation: 1:200
Western Blot: 1:500
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NCBI/Uniprot data below describe general gene information for PBR. It may not necessarily be applicable to this product.
 NCBI GI #    313104268
 NCBI GeneID    706
 NCBI Accession #    P30536.3 [Other Products]
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 UniProt Primary Accession #    P30536 [Other Products]
 UniProt Secondary Accession #    Q53Y59; Q6ICF9; Q96TF6 [Other Products]
 UniProt Related Accession #    P30536 [Other Products]
 Molecular Weight    10,537 Da
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 NCBI Official Full Name    Translocator protein
 NCBI Official Synonym Full Names    translocator protein
 NCBI Official Symbol    TSPO [Similar Products]
 NCBI Official Synonym Symbols   
DBI; IBP; MBR; PBR; PBS; BPBS; BZRP; PKBS; PTBR; mDRC; pk18
[Similar Products]
 NCBI Protein Information    translocator protein
 UniProt Protein Name    Translocator protein
 UniProt Synonym Protein Names   
Mitochondrial benzodiazepine receptor; PKBS; Peripheral-type benzodiazepine receptor; PBR
 UniProt Gene Name    TSPO [Similar Products]
 UniProt Synonym Gene Names    BZRP; MBR; PBR [Similar Products]
 UniProt Entry Name    TSPOA_HUMAN
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 NCBI Summary for PBR    Present mainly in the mitochondrial compartment of peripheral tissues, the protein encoded by this gene interacts with some benzodiazepines and has different affinities than its endogenous counterpart. The protein is a key factor in the flow of cholesterol into mitochondria to permit the initiation of steroid hormone synthesis. Alternatively spliced transcript variants have been reported; one of the variants lacks an internal exon and is considered non-coding, and the other variants encode the same protein. [provided by RefSeq, Feb 2012]
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 UniProt Comments for PBR    TSPO: Responsible for the manifestation of peripheral-type benzodiazepine recognition sites and is most likely to comprise binding domains for benzodiazepines and isoquinoline carboxamides. May play a role in the transport of porphyrins and heme. Plays a role in the transport of cholesterol across mitochondrial membranes in steroidogenic cells. Belongs to the TspO/BZRP family. Interacts with BZRAP1. May interact with STAR. Interacts with MOST-1. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Mitochondrial; Receptor, misc.; Membrane protein, integral; Apoptosis; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 22q13.31

Cellular Component: cytoplasm; integral to membrane; intracellular membrane-bound organelle; mitochondrial outer membrane; mitochondrion; nuclear membrane

Molecular Function: androgen binding; benzodiazepine receptor activity; cholesterol binding; protein binding

Biological Process: adrenal gland development; aging; anion transport; apoptosis; axon regeneration in the peripheral nervous system; behavioral response to pain; cell proliferation; chloride transport; glial cell migration; heme biosynthetic process; lipid transport; negative regulation of nitric oxide biosynthetic process; negative regulation of protein ubiquitination; negative regulation of tumor necrosis factor production; positive regulation of apoptosis; positive regulation of calcium ion transport; positive regulation of mitochondrial depolarization; protein targeting to mitochondrion; regulation of cholesterol transport; regulation of steroid biosynthetic process; response to drug; response to manganese ion; response to progesterone stimulus; response to testosterone stimulus; response to vitamin B1; steroid biosynthetic process; steroid metabolic process
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 Research Articles on PBR    1. Elevations in microglial activity can be measured in vivo with positron emission tomography (PET) using radioligands specific for the 18kD translocator-protein (TSPO), which is expressed on microglia.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-PBR antibodyPathways associated with anti-PBR antibody
 Reference Product  PubMed Publications
 VDAC1 antibody  >15 publications with PBR and VDAC1
 FOS antibody  >4 publications with PBR and FOS
 GAPDH antibody  >2 publications with PBR and GAPDH
 CNTF antibody  >1 publications with PBR and CNTF
 PPARA antibody  >1 publications with PBR and PPARA
 Products by Pathway  Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
Diseases associated with anti-PBR antibodyOrgans/Tissues associated with anti-PBR antibody
 Disease Name  Pubmed Publications
 Brain Diseases Antibodies  >178 publications with PBR and Brain Diseases
 Inflammation Antibodies  >156 publications with PBR and Inflammation
 Cardiovascular Diseases Antibodies  >49 publications with PBR and Cardiovascular Diseases
 Heart Diseases Antibodies  >27 publications with PBR and Heart Diseases
 Kidney Diseases Antibodies  >17 publications with PBR and Kidney Diseases
 Breast Neoplasms Antibodies  >15 publications with PBR and Breast Neoplasms
 Necrosis Antibodies  >15 publications with PBR and Necrosis
 Liver Diseases Antibodies  >14 publications with PBR and Liver Diseases
 Carcinoma Antibodies  >13 publications with PBR and Carcinoma
 Hepatic Encephalopathy Antibodies  >11 publications with PBR and Hepatic Encephalopathy
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >360 publications with PBR and Brain
 Blood Antibodies  >101 publications with PBR and Blood
 Heart Antibodies  >55 publications with PBR and Heart
 Liver Antibodies  >40 publications with PBR and Liver
 Kidney Antibodies  >40 publications with PBR and Kidney
 Nerve Antibodies  >38 publications with PBR and Nerve
 Testis Antibodies  >33 publications with PBR and Testis
 Lung Antibodies  >27 publications with PBR and Lung
 Muscle Antibodies  >25 publications with PBR and Muscle
 Spleen Antibodies  >17 publications with PBR and Spleen
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