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anti-PCDHGC5 antibody :: Rabbit anti-Mouse PCDHGC5 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9204539
Unit / Price
0.08 mL  /  $150 +1 FREE 8GB USB
0.4 mL  /  $340 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

PCDHGC5, Polyclonal Antibody

★Popular Item★
 Also Known As   

PCDHGC5 Antibody (Center)

 Product Synonym Names    Protocadherin gamma-C5; PCDH-gamma-C5; PCDHGC5
 Product Gene Name   

anti-PCDHGC5 antibody

[Similar Products]
 Antibody/Peptide Pairs    PCDHGC5 peptide (MBS9219039) is used for blocking the activity of PCDHGC5 antibody (MBS9204539)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence Positions    499-526
 OMIM    604968
 3D Structure    ModBase 3D Structure for Q9Y5F6
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 Clonality    Polyclonal
 Isotype    Rabbit Ig
 Clone Number    RB31976
 Host    Rabbit
 Species Reactivity    Mouse
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 Specificity    This PCDHGC5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 499-526 amino acids from the Central region of human PCDHGC5.
 Purity/Purification    Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
 Form/Format    Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
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 Function    Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
 Cellular Location    Cell membrane; Single-pass type I membrane protein
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 Preparation and Storage    Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
 Other Notes    Small volumes of anti-PCDHGC5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-PCDHGC5 antibody

   This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes,subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes.
 Product Categories/Family for anti-PCDHGC5 antibody    Neuroscience; Signal Transduction
 Applications Tested/Suitable for anti-PCDHGC5 antibody   

Western Blot (WB), ELISA (EIA), Immunohistochemistry-Paraffin (IHC-P)

 Application Notes for anti-PCDHGC5 antibody    WB~~1:1000
IHC-P~~1:10~50
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 Western Blot (WB) of anti-PCDHGC5 antibody    PCDHGC5 Antibody (Center) western blot analysis in mouse brain tissue lysates (35ug/lane).This demonstrates the PCDHGC5 antibody detected the PCDHGC5 protein (arrow).
anti-PCDHGC5 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-PCDHGC5 antibody    PCDHGC5 Antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded human stomach tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of PCDHGC5 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
anti-PCDHGC5 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for PCDHGC5. It may not necessarily be applicable to this product.
 NCBI GI #    11128023
 NCBI GeneID    56097
 NCBI Accession #    NP_061752.1 [Other Products]
 NCBI Related Accession #    NP_115783.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_018929.2 [Other Products]
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 UniProt Primary Accession #    Q9Y5F6 [Other Products]
 UniProt Secondary Accession #    Q9Y5C2 [Other Products]
 UniProt Related Accession #    Q9Y5F6 [Other Products]
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 NCBI Official Full Name    protocadherin gamma-C5 isoform 1
 NCBI Official Synonym Full Names    protocadherin gamma subfamily C, 5
 NCBI Official Symbol    PCDHGC5 [Similar Products]
 NCBI Official Synonym Symbols   
PCDH-GAMMA-C5
[Similar Products]
 NCBI Protein Information    protocadherin gamma-C5
 UniProt Protein Name    Protocadherin gamma-C5
 Protein Family    Protocadherin
 UniProt Gene Name    PCDHGC5 [Similar Products]
 UniProt Synonym Gene Names    PCDH-gamma-C5 [Similar Products]
 UniProt Entry Name    PCDGM_HUMAN
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 NCBI Summary for PCDHGC5    This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes. [provided by RefSeq, Jul 2008]
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 UniProt Comments for PCDHGC5    PCDHGC5: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 5q31

Cellular Component: integral to membrane; plasma membrane

Molecular Function: calcium ion binding

Biological Process: homophilic cell adhesion
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Product References and Citations for anti-PCDHGC5 antibody

   Wu, Q., et al. Genome Res. 11(3):389-404(2001)
Nollet, F., et al. J. Mol. Biol. 299(3):551-572(2000)
Yagi, T., et al. Genes Dev. 14(10):1169-1180(2000)
Wu, Q., et al. Proc. Natl. Acad. Sci. U.S.A. 97(7):3124-3129(2000)
Wu, Q., et al. Cell 97(6):779-790(1999)
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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