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anti-PD-1/CD279 antibody :: Rabbit PD-1/CD279 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS301923
Immunohistochemistry (IHC)
Unit / Price
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 Product Name   

PD-1/CD279, Polyclonal Antibody

 Also Known As   

Rabbit Anti-Human PD-1/CD279 Polyclonal Antibody

 Product Gene Name   

anti-PD-1/CD279 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    109100
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
Predicted Reactivity: Dog
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 Form/Format    0.1 ml immunogen affinity purified rabbit polyclonal antibody in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.
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 Immunogen    Synthetic peptide derived from near N-terminus of human CD279 protein.
 Control Tissue    Tonsil
 Cellular Localization    Membrane
 Entrez Gene Code    5133
 Pathway    Apoptosis
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 Preparation and Storage    Store at 2-8 degree C. Do not freeze. The user must validate any other storage conditions. When properly stored, the reagent is stable to the date indicated on the label. Do not use the reagent beyond the expiration date. There are no definitive signs to indicate instability of this product; therefore, positive and negative controls should be tested simultaneously with unknown specimens. If unexpected results are observed which cannot be explained by variations in laboratory procedures and a problem with the reagent is suspected, contact Technical Support.
 Other Notes    Small volumes of anti-PD-1/CD279 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-PD-1/CD279 antibody

   CD279 is an immunoglobulin superfamily member, also known as Programmed Cell Death 1. Programmed Cell Death 1 is expressed on a subset of CD4-CD8 thymocytes, and on activated T and B cells. Programmed Cell Death 1 is thought to be involved in lymphocyte clonal selection and peripheral tolerance. The Programmed Cell Death 1 ligands, PDL1 (also known as B7H1) and PDL2 (B7DC), are members of the B7 immunoglobulin superfamily.
 Applications Tested/Suitable for anti-PD-1/CD279 antibody   

Immunohistochemistry (IHC) Paraffin

 Application Notes for anti-PD-1/CD279 antibody    Immunohistochemistry Procedure
Specimen Preparation: Formalin-fixed, paraffin-embedded tissues are suitable for use with this primary antibody. Deparaffinization: Deparaffinize slides using xylene or xylene alternative and graded alcohols. Antibody Dilution: If using the concentrate format of this product, dilute the antibody 1:100. The dilutions are estimates; actual results may differ because of variability in methods and protocols. Antigen Retrieval: Boil tissue section in 1mM EDTA, pH 8.0 for 10 min followed by cooling at room temperature for 20 min. Primary Antibody Incubation: Incubate for 30 minutes at room temperature. Slide Washing: Slides must be washed in between steps. Rinse slides with PBS/0.05% Tween. Visualization: Detect the antibody as instructed by the instructions provided with the visualization system.
Immunohistochemistry Dilution: 1:100
IHC Positive Control: Tonsil
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 Immunohistochemistry (IHC) of anti-PD-1/CD279 antibody    Human tonsil stained with anti-PD-1/CD279 antibody
anti-PD-1/CD279 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for PD-1/CD279. It may not necessarily be applicable to this product.
 NCBI GI #    167857792
 NCBI GeneID    5133
 NCBI Accession #    NP_005009.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_005018.2 [Other Products]
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 UniProt Secondary Accession #    O00517; Q8IX89 [Other Products]
 UniProt Related Accession #    Q15116 [Other Products]
 Molecular Weight    32 kDa
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 NCBI Official Full Name    programmed cell death protein 1
 NCBI Official Synonym Full Names    programmed cell death 1
 NCBI Official Symbol    PDCD1 [Similar Products]
 NCBI Official Synonym Symbols   
PD1; PD-1; CD279; SLEB2; hPD-1; hPD-l; hSLE1
[Similar Products]
 NCBI Protein Information    programmed cell death protein 1; protein PD-1; systemic lupus erythematosus susceptibility 2
 UniProt Protein Name    Programmed cell death protein 1
 UniProt Synonym Protein Names   
CD_antigen: CD279
 UniProt Gene Name    PDCD1 [Similar Products]
 UniProt Synonym Gene Names    PD1; Protein PD-1; hPD-1 [Similar Products]
 UniProt Entry Name    PDCD1_HUMAN
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 NCBI Summary for PD-1/CD279    This gene encodes a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases. [provided by RefSeq, Jul 2008]
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 UniProt Comments for PD-1/CD279    PDCD1: a single-pass type I membrane protein. A negative regulator of activated T cells, is upregulated in human and mouse 'exhausted' T cells during persistent viral infection. A marker of angioimmunoblastic T-cell lymphoma and germinal center associated T cells.

Protein type: Membrane protein, integral; Apoptosis

Chromosomal Location of Human Ortholog: 2q37.3

Cellular Component: integral to membrane; plasma membrane; external side of plasma membrane

Molecular Function: signal transducer activity; protein binding

Biological Process: apoptosis; multicellular organismal development; T cell costimulation; signal transduction; humoral immune response

Disease: Systemic Lupus Erythematosus
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 Research Articles on PD-1/CD279    1. These data strongly support testing of PD-1-blocking agents in combination with standard-of-care chemoradiotherapy for papillomavirus (HPV)-related oropharyngeal cancer .
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-PD-1/CD279 antibodyPathways associated with anti-PD-1/CD279 antibody
 Reference Product  PubMed Publications
 CD4 antibody  >418 publications with PD-1/CD279 and CD4
 CD274 antibody  >336 publications with PD-1/CD279 and CD274
 PDCD1LG2 antibody  >99 publications with PD-1/CD279 and PDCD1LG2
 PTPN6 antibody  >7 publications with PD-1/CD279 and PTPN6
 PTPN11 antibody  >7 publications with PD-1/CD279 and PTPN11
 HLA-DR4 antibody  >1 publications with PD-1/CD279 and HLA-DR4
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Costimulation By The CD28 Family Pathway antibodies  Costimulation By The CD28 Family Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 PD-1 Signaling Pathway antibodies  PD-1 Signaling Pathway Diagram
 T Cell Receptor Signaling Pathway antibodies  T Cell Receptor Signaling Pathway Diagram
 T Cell Receptor Signaling Pathway antibodies  T Cell Receptor Signaling Pathway Diagram
Diseases associated with anti-PD-1/CD279 antibodyOrgans/Tissues associated with anti-PD-1/CD279 antibody
 Disease Name  Pubmed Publications
 Liver Diseases Antibodies  >147 publications with PD-1/CD279 and Liver Diseases
 Inflammation Antibodies  >115 publications with PD-1/CD279 and Inflammation
 Melanoma Antibodies  >79 publications with PD-1/CD279 and Melanoma
 Necrosis Antibodies  >75 publications with PD-1/CD279 and Necrosis
 Lupus Erythematosus, Systemic Antibodies  >72 publications with PD-1/CD279 and Lupus Erythematosus, Systemic
 Lung Diseases Antibodies  >58 publications with PD-1/CD279 and Lung Diseases
 Lung Neoplasms Antibodies  >38 publications with PD-1/CD279 and Lung Neoplasms
 Adenocarcinoma Antibodies  >35 publications with PD-1/CD279 and Adenocarcinoma
 Kidney Diseases Antibodies  >28 publications with PD-1/CD279 and Kidney Diseases
 Liver Neoplasms Antibodies  >26 publications with PD-1/CD279 and Liver Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >945 publications with PD-1/CD279 and Blood
 Kidney Antibodies  >36 publications with PD-1/CD279 and Kidney
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