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anti-PDGF antibody :: Rabbit PDGF-A Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS551005 anti-PDGF antibody
Unit / Price
0.1 mg  /  $280 +1 FREE 8GB USB
0.2 mg  /  $385 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

PDGF-A, Polyclonal Antibody

 Also Known As   

Rabbit anti PDGF-A Polyclonal

 Product Synonym Names    Rabbit anti PDGF-A Polyclonal purified; pdgf-aa; platelet derived growth factor; polyclonal; pab
 Product Gene Name   

anti-PDGF antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    173430
 3D Structure    ModBase 3D Structure for P04085
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Serum IgG fraction was purified by Protein G affinity chromatography.
 Form/Format    Lyophilized from sterile filtered PBS solution at a concentration of 1mg/ml.
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 Source Note    Polyclonal PDGF-A antibody was produced from sera of rabbits immunized with synthetic protein containing PDGF-A antigenic determinants.
 Reconstitution    A quick spin of the vial followed by reconstitution in distilled water. This solution can then be diluted into other buffers
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 Preparation and Storage    The lyophilized antibody is stable for at least 1 year from date of receipt at -20 degree C.
Upon reconstitution, this antibody can be stored in working aliquots at 2 degree - 8 degree C for one month, or at -20 degree C for six months without detectable loss of activity.

Avoid repeated freeze/thaw cycles.
Shelf Life: >12 months
 Other Notes    Small volumes of anti-PDGF antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-PDGF antibody

   PDGF is synthesized mainly by megakaryocytes. It is stored in the alpha granules of platelets from which it is released after cell activation of platelets. Platelets synthesize a mixture of the three possible isoforms (BB,AB,AA) while fibroblasts stimulated with EGF synthesize AA homodimers. PDGF receptors are expressed in fibroblasts, osteoblasts, chondroblasts, smooth muscle cells, glial cells, and endothelial cells.Two related receptors, are PDGFRalpha (CD140a) or PDGFRbeta (CD140b).In contrast to many other cytokines PDGF is not released into the circulation. PDGF binds to several plasma proteins and also to proteins of the extracellular matrix which facilitates local concentration of the factor. The factor functions as a local autocrine and paracrine growth factor. In the adult organism PDGF is involved in wound healing processes. The aberrant expression of PDGF is observed with vascular proliferative diseases such as atherosclerosis. PDGF regulates the synthesis of its own receptor and also influences the expression of membrane receptors for IL1, EGF, 5-Hydroxytryptamine, LDL, transferrin, and muscarinergic receptor.
 Product Categories/Family for anti-PDGF antibody    Polyclonal
 Applications Tested/Suitable for anti-PDGF antibody   

Western Blot (WB), IHC (Immunohistochemistry), ELISA (EIA)

 Application Notes for anti-PDGF antibody    ELISA: Use at a concentration range of 1-2ug/ml.
Western blot:A suitable range of concentrations of this antibody for WB detection is 2-10 ug/ml.
IHC: A suitable range of concentrations of this antibody for IHC is 2-10 ug/ml.
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NCBI/Uniprot data below describe general gene information for PDGF. It may not necessarily be applicable to this product.
 NCBI GI #    77695917
 NCBI GeneID    5154
 NCBI Accession #    NP_002598.4 [Other Products]
 NCBI GenBank Nucleotide #    NM_002607.5 [Other Products]
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 UniProt Primary Accession #    P04085 [Other Products]
 UniProt Secondary Accession #    B5BU73 [Other Products]
 UniProt Related Accession #    P04085; Q32M96; Q9BQF3; Q9UGN0 [Other Products]
 Molecular Weight    24,043 Da
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 NCBI Official Full Name    platelet-derived growth factor subunit A isoform 1 preproprotein
 UniProt Protein Name    Platelet-derived growth factor subunit A
 UniProt Synonym Protein Names   
PDGF-1; Platelet-derived growth factor A chain; Platelet-derived growth factor alpha polypeptide
 UniProt Gene Name    PDGFA [Similar Products]
 UniProt Synonym Gene Names    PDGF1; PDGF subunit A [Similar Products]
 UniProt Entry Name    PDGFA_HUMAN
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 NCBI Summary for PDGF    The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer or as a heterodimer with the platelet-derived growth factor beta polypeptide, where the dimers are connected by disulfide bonds. Studies using knockout mice have shown cellular defects in oligodendrocytes, alveolar smooth muscle cells, and Leydig cells in the testis; knockout mice die either as embryos or shortly after birth. Two splice variants have been identified for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for PDGF    PDGFA: Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal lung alveolar septum formation during embryogenesis, normal development of the gastrointestinal tract, normal development of Leydig cells and spermatogenesis. Required for normal oligodendrocyte development and normal myelination in the spinal cord and cerebellum. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFB. Belongs to the PDGF/VEGF growth factor family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal peptide; Cell cycle regulation; Cytokine

Chromosomal Location of Human Ortholog: 7p22

Cellular Component: Golgi membrane; extracellular space; microvillus; cell surface; endoplasmic reticulum lumen; extracellular region

Molecular Function: collagen binding; protein binding; protein homodimerization activity; growth factor activity; protein heterodimerization activity; platelet-derived growth factor binding; platelet-derived growth factor receptor binding

Biological Process: skin development; extracellular matrix organization and biogenesis; wound healing; nerve growth factor receptor signaling pathway; negative chemotaxis; platelet-derived growth factor receptor signaling pathway; cell projection biogenesis; response to estradiol stimulus; positive regulation of MAP kinase activity; positive regulation of fibroblast proliferation; regulation of smooth muscle cell migration; platelet degranulation; hair follicle development; cell-cell signaling; positive regulation of MAPKKK cascade; transforming growth factor beta receptor signaling pathway; positive regulation of cell proliferation; positive regulation of mesenchymal cell proliferation; response to wounding; angiogenesis; regulation of peptidyl-tyrosine phosphorylation; inner ear development; epidermal growth factor receptor signaling pathway; response to drug; platelet activation; response to inorganic substance; phosphoinositide-mediated signaling; fibroblast growth factor receptor signaling pathway; response to retinoic acid; negative regulation of phosphatidylinositol biosynthetic process; positive regulation of protein amino acid autophosphorylation; positive regulation of phosphoinositide 3-kinase cascade; cell activation; positive regulation of protein kinase B signaling cascade; organ morphogenesis; positive regulation of cell division; regulation of actin cytoskeleton organization and biogenesis; response to hypoxia; innate immune response; actin cytoskeleton organization and biogenesis; blood coagulation; alveolus development; positive regulation of DNA replication; positive regulation of cell migration
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-PDGF antibodyPathways associated with anti-PDGF antibody
 Reference Product  PubMed Publications
 PDGFRA antibody  >36 publications with PDGF and PDGFRA
 SPARC antibody  >2 publications with PDGF and SPARC
 Products by Pathway  Pathway Diagram
 Ceramide Signaling Pathway antibodies  Ceramide Signaling Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokines And Inflammatory Response Pathway antibodies  Cytokines And Inflammatory Response Pathway Diagram
 Down-stream Signal Transduction Pathway antibodies  Down-stream Signal Transduction Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Formation Of Platelet Plug Pathway antibodies  Formation Of Platelet Plug Pathway Diagram
 Gap Junction Pathway antibodies  Gap Junction Pathway Diagram
Diseases associated with anti-PDGF antibodyOrgans/Tissues associated with anti-PDGF antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >36 publications with PDGF and Neoplasms
 Inflammation Antibodies  >8 publications with PDGF and Inflammation
 Fibrosis Antibodies  >8 publications with PDGF and Fibrosis
 Congenital Abnormalities Antibodies  >7 publications with PDGF and Congenital Abnormalities
 Endocrine Gland Neoplasms Antibodies  >5 publications with PDGF and Endocrine Gland Neoplasms
 Skin Diseases Antibodies  >5 publications with PDGF and Skin Diseases
 Adenocarcinoma Antibodies  >5 publications with PDGF and Adenocarcinoma
 Nervous System Diseases Antibodies  >4 publications with PDGF and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >4 publications with PDGF and Cardiovascular Diseases
 Lung Diseases Antibodies  >4 publications with PDGF and Lung Diseases
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >9 publications with PDGF and Lung
 Brain Antibodies  >7 publications with PDGF and Brain
 Liver Antibodies  >6 publications with PDGF and Liver
 Mouth Antibodies  >5 publications with PDGF and Mouth
 Connective Tissue Antibodies  >5 publications with PDGF and Connective Tissue
 Kidney Antibodies  >5 publications with PDGF and Kidney
 Embryonic Tissue Antibodies  >5 publications with PDGF and Embryonic Tissue
 Ovary Antibodies  >4 publications with PDGF and Ovary
 Heart Antibodies  >4 publications with PDGF and Heart
 Testis Antibodies  >2 publications with PDGF and Testis
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