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anti-PDGF antibody :: Rabbit anti-Mouse PDGF Receptor alpha Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS535228
Western Blot (WB)
Unit / Price
0.2 mL  /  $550 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

PDGF Receptor alpha, Polyclonal Antibody

 Also Known As   

PDGF Receptor alpha antibody

 Product Synonym Names    Polyclonal PDGF Receptor alpha; Anti-PDGF Receptor alpha; Platelet Derived Growth Factor Receptor alpha; PDGFRB; PDGFR alpha
 Product Gene Name   

anti-PDGF antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    173490
 3D Structure    ModBase 3D Structure for P16234
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Mouse
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 Specificity    Human
 Purity/Purification    PDGF Receptor alpha antibody was purified by affinity chromatography.
 Form/Format    Immunoaffinity purified rabbit IgG supplied in in 70% storage buffer(0.2 M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% Sodium Azide) and 30% glycerol.
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 Biological Significance    Platelet derived growth factor receptor (PDGF Receptor) is a transmembrane glycoprotein of 170-185 kDa which undergoes homo or heterodimerization into complexes of alpha and beta subunits upon ligand binding, depending on the isoform of PDGF (PDGF AA, BB or AB) that binds. The phosphorylation of tyrosine residues in the now activated receptor can control multiple signaling events such as actin reorganization, transcription, cell growth, migration and differentiation.
 Biohazard Information    This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling.
 Immunogen    PDGF receptor alpha antibody was raised in rabbit using peptide corresponding to amino acids 1035-1053 (C-GKRNRHSSQTSEESAIETG) of human PDGF Receptor slpha as the immunogen.
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 Preparation and Storage    Aliquot and store at -20 degree C. Avoid repeated Freeze/Thaw cycles
 Other Notes    Small volumes of anti-PDGF antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-PDGF antibody

   Rabbit polyclonal PDGF Receptor alpha antibody
 Product Categories/Family for anti-PDGF antibody    Cytokines & Growth Factors
 Applications Tested/Suitable for anti-PDGF antibody   

Immunoprecipitation (IP), Western Blot (WB)

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 Western Blot (WB) of anti-PDGF antibody    Western blot analysis of 3T3/NIH cell lysate probed with Anti-PDGF Receptor alpha (1:500 dilution).
anti-PDGF antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for PDGF. It may not necessarily be applicable to this product.
 NCBI GI #    5453870
 NCBI GeneID    5156
 NCBI Accession #    NP_006197.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_006206.4 [Other Products]
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 UniProt Primary Accession #    P16234 [Other Products]
 UniProt Secondary Accession #    Q6P4H5; Q96KZ7; Q9UD28; B2RE69; E9PBH0 [Other Products]
 UniProt Related Accession #    P16234 [Other Products]
 Molecular Weight    150-170 kDa (predicted detection band MW)
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 NCBI Official Full Name    platelet-derived growth factor receptor alpha
 NCBI Official Synonym Full Names    platelet-derived growth factor receptor, alpha polypeptide
 NCBI Official Symbol    PDGFRA [Similar Products]
 NCBI Official Synonym Symbols   
CD140A; PDGFR2; PDGFR-2; RHEPDGFRA
[Similar Products]
 NCBI Protein Information    platelet-derived growth factor receptor alpha
 UniProt Protein Name    Platelet-derived growth factor receptor alpha
 UniProt Synonym Protein Names   
Alpha platelet-derived growth factor receptor; Alpha-type platelet-derived growth factor receptor; CD140 antigen-like family member A; CD140a antigen; Platelet-derived growth factor alpha receptor; Platelet-derived growth factor receptor 2; PDGFR-2; CD_antigen: CD140a
 UniProt Gene Name    PDGFRA [Similar Products]
 UniProt Synonym Gene Names    PDGFR2; RHEPDGFRA; PDGF-R-alpha; PDGFR-alpha; PDGFR-2 [Similar Products]
 UniProt Entry Name    PGFRA_HUMAN
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 NCBI Summary for PDGF    This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies suggest that this gene plays a role in organ development, wound healing, and tumor progression. Mutations in this gene have been associated with idiopathic hypereosinophilic syndrome, somatic and familial gastrointestinal stromal tumors, and a variety of other cancers. [provided by RefSeq, Mar 2012]
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 UniProt Comments for PDGF    PDGFRA: a receptor tyrosine kinase of the PDGFR family that binds members of the platelet-derived growth factor family. The identity of the growth factor bound determines whether the functional receptor is a homodimer or a heterodimer, composed of both PDGFR-alpha and -beta. Ligand binding induces receptor dimerization and autophosphorylation. Particularly important for kidney development since mice heterozygous for the receptor exhibit defective kidney phenotypes. Chromosomal rearrangments activate PDGFRalpha by fusion to BCR, causing atypical chronic myelogenous leukemia (CML), and to FIP1L1, causing idiopathic hypereosinophilic syndrome. Activating point mutations cause a minority of gastrointestinal stromal tumors (GIST). Promoter polymorphisms linked to neural tube defects including spina bifida, verified by mouse mutant model. Inhibitors: Gleevec, Sutent. OMIM: Two alternatively-spliced isoforms have been described.

Protein type: EC 2.7.10.1; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor); Membrane protein, integral; TK group; PDGFR family

Chromosomal Location of Human Ortholog: 4q12

Cellular Component: microvillus; membrane; integral to plasma membrane; cytoplasm; plasma membrane; nucleus; intrinsic to plasma membrane; external side of plasma membrane

Molecular Function: vascular endothelial growth factor receptor activity; protein binding; protein homodimerization activity; platelet-derived growth factor binding; platelet-derived growth factor receptor binding; platelet-derived growth factor alpha-receptor activity; transmembrane receptor protein tyrosine kinase activity; ATP binding

Biological Process: estrogen metabolic process; extracellular matrix organization and biogenesis; peptidyl-tyrosine phosphorylation; regulation of chemotaxis; nerve growth factor receptor signaling pathway; viral reproduction; wound healing; protein amino acid autophosphorylation; platelet-derived growth factor receptor signaling pathway; cardiac myofibril assembly; palate development; positive regulation of fibroblast proliferation; elevation of cytosolic calcium ion concentration; Leydig cell differentiation; embryonic digestive tract morphogenesis; luteinization; positive regulation of cell proliferation; male genitalia development; epidermal growth factor receptor signaling pathway; phosphoinositide-mediated signaling; fibroblast growth factor receptor signaling pathway; adrenal gland development; in utero embryonic development; positive regulation of phosphoinositide 3-kinase activity; embryonic cranial skeleton morphogenesis; odontogenesis of dentine-containing teeth; embryonic skeletal morphogenesis; positive regulation of phosphoinositide 3-kinase cascade; cell activation; innate immune response; hemopoietic progenitor cell differentiation; positive regulation of DNA replication; lung development; positive regulation of cell migration

Disease: Gastrointestinal Stromal Tumor; Hypereosinophilic Syndrome, Idiopathic
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 Research Articles on PDGF    1. observations suggest that NRP-1 is involved in megakaryocytopoiesis through complex formation with PDGFRs, and that NRP-1-PDGFR-complexes may contribute to effective cellular functions mediated by thrombopoietin and PDGF in megakaryocytic cells
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-PDGF antibodyPathways associated with anti-PDGF antibody
 Reference Product  PubMed Publications
 PDGFRB antibody  >179 publications with PDGF and PDGFRB
 PDGFA antibody  >23 publications with PDGF and PDGFA
 PDGFB antibody  >15 publications with PDGF and PDGFB
 PDGFC antibody  >8 publications with PDGF and PDGFC
 PIK3R1 antibody  >6 publications with PDGF and PIK3R1
 GRB2 antibody  >3 publications with PDGF and GRB2
 CRK antibody  >2 publications with PDGF and CRK
 PLCG1 antibody  >1 publications with PDGF and PLCG1
 Products by Pathway  Pathway Diagram
 ATF-2 Transcription Factor Network Pathway antibodies  ATF-2 Transcription Factor Network Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Angiogenesis Pathway antibodies  Angiogenesis Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Cardiac Progenitor Differentiation Pathway antibodies  Cardiac Progenitor Differentiation Pathway Diagram
 Central Carbon Metabolism In Cancer Pathway antibodies  Central Carbon Metabolism In Cancer Pathway Diagram
 Central Carbon Metabolism In Cancer Pathway antibodies  Central Carbon Metabolism In Cancer Pathway Diagram
 Choline Metabolism In Cancer Pathway antibodies  Choline Metabolism In Cancer Pathway Diagram
 Choline Metabolism In Cancer Pathway antibodies  Choline Metabolism In Cancer Pathway Diagram
Diseases associated with anti-PDGF antibodyOrgans/Tissues associated with anti-PDGF antibody
 Disease Name  Pubmed Publications
 Gastrointestinal Stromal Tumors Antibodies  >564 publications with PDGF and Gastrointestinal Stromal Tumors
 Hypereosinophilic Syndrome Antibodies  >237 publications with PDGF and Hypereosinophilic Syndrome
 Neoplasm Metastasis Antibodies  >46 publications with PDGF and Neoplasm Metastasis
 Lung Diseases Antibodies  >41 publications with PDGF and Lung Diseases
 Lung Neoplasms Antibodies  >39 publications with PDGF and Lung Neoplasms
 Cardiovascular Diseases Antibodies  >35 publications with PDGF and Cardiovascular Diseases
 Disease Models, Animal Antibodies  >29 publications with PDGF and Disease Models, Animal
 Heart Diseases Antibodies  >25 publications with PDGF and Heart Diseases
 Congenital Abnormalities Antibodies  >24 publications with PDGF and Congenital Abnormalities
 Liver Neoplasms Antibodies  >24 publications with PDGF and Liver Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >198 publications with PDGF and Blood
 Bone Antibodies  >146 publications with PDGF and Bone
 Stomach Antibodies  >132 publications with PDGF and Stomach
 Brain Antibodies  >113 publications with PDGF and Brain
 Bone Marrow Antibodies  >101 publications with PDGF and Bone Marrow
 Muscle Antibodies  >97 publications with PDGF and Muscle
 Lung Antibodies  >63 publications with PDGF and Lung
 Intestine Antibodies  >60 publications with PDGF and Intestine
 Vascular Antibodies  >60 publications with PDGF and Vascular
 Liver Antibodies  >57 publications with PDGF and Liver
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