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anti-PDGF antibody :: Goat PDGF Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS534137 anti-PDGF antibody
Unit / Price
1 mg  /  $550 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

PDGF, Polyclonal Antibody

 Also Known As   

PDGF antibody

 Product Synonym Names    Polyclonal PDGF; Anti-PDGF; PDGF-BB; PDGF-AB; PDGF-AA; Platelet Derived Growth Factor
 Product Gene Name   

anti-PDGF antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    173430
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Goat
 Species Reactivity    Bovine, Mouse, Pig
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 Specificity    Human
 Purity/Purification    PDGF antibody was purified by DEAE chromatgraphy.
 Form/Format    Affi-Gel Blue purified protein supplied in 0.1M tris-glycine, pH 7.0.
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 Biological Significance    Platelet derived growth factor receptor (PDGF Receptor) is a transmembrane glycoprotein of 170-185 kDa which undergoes homo or heterodimerization into complexes of alpha and beta subunits upon ligand binding, depending on the isoform of PDGF (PDGF AA, BB or AB) that binds. The phosphorylation of tyrosine residues in the now activated receptor can control multiple signaling events such as actin reorganization, transcription, cell growth, migration and differentiation.
 Immunogen    PDGF antibody was raised in goat using purified human PDGF-AB as the immunogen.
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 Preparation and Storage    Aliquot and store at -20 degree C. Avoid repeated Freeze/Thaw cycles
 Other Notes    Small volumes of anti-PDGF antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-PDGF antibody

   Goat polyclonal PDGF antibody
 Product Categories/Family for anti-PDGF antibody    Cytokines & Growth Factors
 Applications Tested/Suitable for anti-PDGF antibody   

Western Blot (WB)

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NCBI/Uniprot data below describe general gene information for PDGF. It may not necessarily be applicable to this product.
 NCBI GI #    385595
 NCBI GeneID    5154
 NCBI Accession #    AAB26566.1 [Other Products]
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 UniProt Secondary Accession #    B5BU73 [Other Products]
 UniProt Related Accession #    P04085 [Other Products]
 Molecular Weight    14-16 kDa (predicted detection band MW)
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 NCBI Official Full Name    platelet-derived growth factor A-chain, partial
 NCBI Official Synonym Full Names    platelet-derived growth factor alpha polypeptide
 NCBI Official Symbol    PDGFA [Similar Products]
 NCBI Official Synonym Symbols   
PDGF1; PDGF-A
[Similar Products]
 NCBI Protein Information    platelet-derived growth factor subunit A
 UniProt Protein Name    Platelet-derived growth factor subunit A
 UniProt Synonym Protein Names   
PDGF-1; Platelet-derived growth factor A chain; Platelet-derived growth factor alpha polypeptide
 Protein Family    PDGF-related-transforming protein
 UniProt Gene Name    PDGFA [Similar Products]
 UniProt Synonym Gene Names    PDGF1; PDGF subunit A [Similar Products]
 UniProt Entry Name    PDGFA_HUMAN
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 NCBI Summary for PDGF    The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer or as a heterodimer with the platelet-derived growth factor beta polypeptide, where the dimers are connected by disulfide bonds. Studies using knockout mice have shown cellular defects in oligodendrocytes, alveolar smooth muscle cells, and Leydig cells in the testis; knockout mice die either as embryos or shortly after birth. Two splice variants have been identified for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for PDGF    PDGFA: Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal lung alveolar septum formation during embryogenesis, normal development of the gastrointestinal tract, normal development of Leydig cells and spermatogenesis. Required for normal oligodendrocyte development and normal myelination in the spinal cord and cerebellum. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFB. Belongs to the PDGF/VEGF growth factor family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell cycle regulation; Secreted; Cytokine; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 7p22

Cellular Component: Golgi membrane; extracellular space; cell surface; microvillus; endoplasmic reticulum lumen; extracellular region

Molecular Function: collagen binding; protein binding; protein homodimerization activity; growth factor activity; protein heterodimerization activity; platelet-derived growth factor binding; platelet-derived growth factor receptor binding

Biological Process: skin development; extracellular matrix organization and biogenesis; nerve growth factor receptor signaling pathway; wound healing; negative chemotaxis; platelet-derived growth factor receptor signaling pathway; cell projection biogenesis; response to estradiol stimulus; positive regulation of MAP kinase activity; positive regulation of fibroblast proliferation; platelet degranulation; regulation of smooth muscle cell migration; hair follicle development; positive regulation of MAPKKK cascade; cell-cell signaling; transforming growth factor beta receptor signaling pathway; positive regulation of mesenchymal cell proliferation; positive regulation of cell proliferation; response to wounding; angiogenesis; regulation of peptidyl-tyrosine phosphorylation; inner ear development; epidermal growth factor receptor signaling pathway; response to drug; platelet activation; phosphoinositide-mediated signaling; response to inorganic substance; fibroblast growth factor receptor signaling pathway; response to retinoic acid; negative regulation of phosphatidylinositol biosynthetic process; positive regulation of protein amino acid autophosphorylation; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of protein kinase B signaling cascade; cell activation; organ morphogenesis; regulation of actin cytoskeleton organization and biogenesis; positive regulation of cell division; response to hypoxia; innate immune response; blood coagulation; actin cytoskeleton organization and biogenesis; alveolus development; positive regulation of DNA replication; positive regulation of cell migration
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 Research Articles on PDGF    1. Patients with Graves ophthalmopathy had significantly higher serum levels of PDGF-AA than controls. Immunosuppressive therapy removed differences.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-PDGF antibodyPathways associated with anti-PDGF antibody
 Reference Product  PubMed Publications
 PDGFB antibody  >31 publications with PDGF and PDGFB
 PDGFRB antibody  >23 publications with PDGF and PDGFRB
 PDGFRA antibody  >23 publications with PDGF and PDGFRA
 SPP1 antibody  >3 publications with PDGF and SPP1
 THBS1 antibody  >1 publications with PDGF and THBS1
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Diseases associated with anti-PDGF antibodyOrgans/Tissues associated with anti-PDGF antibody
 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >24 publications with PDGF and Carcinoma
 Adenocarcinoma Antibodies  >17 publications with PDGF and Adenocarcinoma
 Inflammation Antibodies  >12 publications with PDGF and Inflammation
 Fibrosis Antibodies  >9 publications with PDGF and Fibrosis
 Disease Models, Animal Antibodies  >8 publications with PDGF and Disease Models, Animal
 Neoplasms, Experimental Antibodies  >8 publications with PDGF and Neoplasms, Experimental
 Cell Transformation, Neoplastic Antibodies  >7 publications with PDGF and Cell Transformation, Neoplastic
 Liver Diseases Antibodies  >4 publications with PDGF and Liver Diseases
 Mesothelioma Antibodies  >4 publications with PDGF and Mesothelioma
 Pancreatic Neoplasms Antibodies  >4 publications with PDGF and Pancreatic Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >14 publications with PDGF and Liver
 Brain Antibodies  >11 publications with PDGF and Brain
 Lung Antibodies  >10 publications with PDGF and Lung
 Embryonic Tissue Antibodies  >9 publications with PDGF and Embryonic Tissue
 Connective Tissue Antibodies  >8 publications with PDGF and Connective Tissue
 Kidney Antibodies  >6 publications with PDGF and Kidney
 Intestine Antibodies  >5 publications with PDGF and Intestine
 Nerve Antibodies  >5 publications with PDGF and Nerve
 Testis Antibodies  >5 publications with PDGF and Testis
 Mouth Antibodies  >5 publications with PDGF and Mouth
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