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anti-PDGFRB antibody :: Rabbit anti-Human, Mouse PDGFRB / PDGFR Beta Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS246766
Immunohistochemistry (IHC)
Unit / Price
0.05 mg  /  $495 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

PDGFRB / PDGFR Beta, Polyclonal Antibody

 Also Known As   

Rabbit Polyclonal (IgG) to Human PDGFRB / PDGFR Beta

 Product Synonym Names    Anti-PDGFRB / PDGFR Beta Antibody IHC-plus; PDGFRB; CD140B; Beta pdfgr; Beta type PDGFR; BPDGFR; CD140b antigen; IBGC4; JTK12; PDGF-beta R; PDGF-R-beta; PDGFR; PDGFRbeta; PDGF receptor beta; PDGF-R; PDGFbetaR; PDGFR Beta; PDGFR-1; PDGFR-beta; BetaPDGFR; Pdgf beta-receptor; PDGFR1; Human PDGFRB; PDGFR Beta
 Product Gene Name   

anti-PDGFRB antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    phenotype 615007
 3D Structure    ModBase 3D Structure for P09619
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse
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 Specificity    Near C-terminal
 Purity/Purification    Protein A Purified
 Form/Format    10mM PBS, pH 7.4, with 0.2% BSA and 0.09% Sodium Azide
 Concentration    1 mg/ml (lot specific)
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 Target Species    Human
 Immunogen Description    A synthetic peptide derived from near the C-terminus of human PDGFR, beta.
 Immunogen Type    Synthetic peptide
 Immunogen    PDGFRB / PDGFR Beta antibody was raised against a synthetic peptide derived from near the C-terminus of human PDGFR, beta.
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 Preparation and Storage    Stable for 24 months when stored at 2-8 degree C.
 Other Notes    Small volumes of anti-PDGFRB antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-PDGFRB antibody

   PDGFRB, a PDGF Receptor type protein kinase, binds only BB PDGF homodimers.
 Product Categories/Family for anti-PDGFRB antibody    Family: Protein Kinase
Subfamily: PDGF Receptor
 Applications Tested/Suitable for anti-PDGFRB antibody   

Immunohistochemistry (IHC - Paraffin)

 Application Notes for anti-PDGFRB antibody    IHC-P (20 ug/ml)
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 Immunohistochemistry (IHC) of anti-PDGFRB antibody    Anti-PDGFRB antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 20 ug/ml.
anti-PDGFRB antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for PDGFRB. It may not necessarily be applicable to this product.
 NCBI GI #    4505683
 NCBI GeneID    5159
 NCBI Accession #    NP_002600.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_002609.3 [Other Products]
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 UniProt Primary Accession #    P09619 [Other Products]
 UniProt Secondary Accession #    Q8N5L4; B5A957 [Other Products]
 UniProt Related Accession #    P09619 [Other Products]
 Molecular Weight    37,412 Da
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 NCBI Official Full Name    platelet-derived growth factor receptor beta
 NCBI Official Synonym Full Names    platelet-derived growth factor receptor, beta polypeptide
 NCBI Official Symbol    PDGFRB [Similar Products]
 NCBI Official Synonym Symbols   
IMF1; IBGC4; JTK12; PDGFR; CD140B; PDGFR1; PDGFR-1
[Similar Products]
 NCBI Protein Information    platelet-derived growth factor receptor beta; PDGFR-beta; PDGF-R-beta; CD140 antigen-like family member B; platelet-derived growth factor receptor 1; beta-type platelet-derived growth factor receptor
 UniProt Protein Name    Platelet-derived growth factor receptor beta
 UniProt Synonym Protein Names   
Beta platelet-derived growth factor receptor; Beta-type platelet-derived growth factor receptor; CD140 antigen-like family member B; Platelet-derived growth factor receptor 1; PDGFR-1; CD_antigen: CD140b
 Protein Family    Platelet-derived growth factor receptor
 UniProt Gene Name    PDGFRB [Similar Products]
 UniProt Synonym Gene Names    PDGFR; PDGFR1; PDGF-R-beta; PDGFR-beta; PDGFR-1 [Similar Products]
 UniProt Entry Name    PGFRB_HUMAN
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 NCBI Summary for PDGFRB    This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia. [provided by RefSeq, Jul 2008]
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 UniProt Comments for PDGFRB    PDGFRB: a receptor tyrosine kinase of the PDGFR family that binds members of the platelet-derived growth factor family. The identity of the growth factor bound determines whether the functional receptor is a homodimer or a heterodimer, composed of both PDGFR-alpha and -beta. Ligand binding induces receptor dimerization and autophosphorylation, thereby recruiting SH2-containing proteins including Grb2, Src, GAP, PTPN11, PI3 kinase, PLC-gamma and Nck. Regulates cell growth, actin reorganization, migration and differentiation. A variety of myeloproliferative disorders and cancers result from translocations that activate PDGFRbeta by fusion with proteins such as TEL/ETV6, H2, CEV14/TRP11, rabaptin 5, and huntington interacting protein 1. Gleevec treatment of TEL fusions has been successful. Overexpressed in metastatic medulloblastoma. Inhibitors: Gleevec, Sutent.

Protein type: EC 2.7.10.1; Oncoprotein; Protein kinase, TK; Membrane protein, integral; Protein kinase, tyrosine (receptor); Kinase, protein; TK group; PDGFR family

Chromosomal Location of Human Ortholog: 5q33.1

Cellular Component: lysosomal lumen; focal adhesion; cell surface; membrane; cytoplasm; cytoplasmic membrane-bound vesicle; apical plasma membrane; plasma membrane; integral to membrane; nucleus; intrinsic to plasma membrane

Molecular Function: protein binding; platelet activating factor receptor activity; platelet-derived growth factor binding; platelet-derived growth factor beta-receptor activity; protein-tyrosine kinase activity; platelet-derived growth factor receptor binding; phosphoinositide 3-kinase binding; platelet-derived growth factor receptor activity; protein kinase binding; ATP binding; receptor binding

Biological Process: positive regulation of phosphoprotein phosphatase activity; peptidyl-tyrosine phosphorylation; nerve growth factor receptor signaling pathway; wound healing; response to toxin; positive regulation of smooth muscle cell proliferation; protein amino acid autophosphorylation; positive regulation of collagen biosynthetic process; cardiac myofibril assembly; platelet-derived growth factor receptor signaling pathway; signal transduction; positive regulation of smooth muscle cell migration; response to estradiol stimulus; smooth muscle development; positive regulation of MAP kinase activity; positive regulation of cell proliferation; tissue homeostasis; phosphatidylinositol metabolic process; regulation of peptidyl-tyrosine phosphorylation; inner ear development; epidermal growth factor receptor signaling pathway; cell migration; phosphoinositide-mediated signaling; fibroblast growth factor receptor signaling pathway; response to retinoic acid; positive regulation of mitosis; adrenal gland development; in utero embryonic development; positive regulation of chemotaxis; positive regulation of phosphoinositide 3-kinase activity; positive regulation of phosphoinositide 3-kinase cascade; glycosaminoglycan biosynthetic process; G-protein coupled receptor protein signaling pathway; response to hyperoxia; response to hydrogen peroxide; skeletal morphogenesis; regulation of actin cytoskeleton organization and biogenesis; innate immune response; negative regulation of apoptosis; positive regulation of cell migration

Disease: Myeloproliferative Disorder, Chronic, With Eosinophilia; Myofibromatosis, Infantile, 1; Basal Ganglia Calcification, Idiopathic, 1; Basal Ganglia Calcification, Idiopathic, 4
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 Research Articles on PDGFRB    1. PDGFD-PDGFRbeta signalling is required for human neocortical development and local production of growth factors by radial glia supports the expanded germinal region and progenitor heterogeneity of species with large brains
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products related to Rabbit Polyclonal (IgG) to Human PDGFRB / PDGFR Beta
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 MBS246766  Rabbit Polyclonal (IgG) to Human PDGFRB / PDGFR Beta  MBS240176  Rabbit Polyclonal to Human PDGFRB / PDGFR Beta
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 MBS240175  Rabbit Polyclonal to Human PDGFRB / PDGFR Beta
Products associated with anti-PDGFRB antibodyPathways associated with anti-PDGFRB antibody
 Reference Product  PubMed Publications
 PDGFB antibody  >686 publications with PDGFRB and PDGFB
 PTPN11 antibody  >32 publications with PDGFRB and PTPN11
 GRB2 antibody  >27 publications with PDGFRB and GRB2
 FYN antibody  >16 publications with PDGFRB and FYN
 NCK2 antibody  >3 publications with PDGFRB and NCK2
 NCK1 antibody  >2 publications with PDGFRB and NCK1
 PLCG1 antibody  >1 publications with PDGFRB and PLCG1
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Diseases associated with anti-PDGFRB antibodyOrgans/Tissues associated with anti-PDGFRB antibody
 Disease Name  Pubmed Publications
 Fibrosis Antibodies  >350 publications with PDGFRB and Fibrosis
 Cardiovascular Diseases Antibodies  >280 publications with PDGFRB and Cardiovascular Diseases
 Disease Models, Animal Antibodies  >248 publications with PDGFRB and Disease Models, Animal
 Brain Diseases Antibodies  >187 publications with PDGFRB and Brain Diseases
 Lung Diseases Antibodies  >163 publications with PDGFRB and Lung Diseases
 Inflammation Antibodies  >160 publications with PDGFRB and Inflammation
 Liver Diseases Antibodies  >159 publications with PDGFRB and Liver Diseases
 Kidney Diseases Antibodies  >158 publications with PDGFRB and Kidney Diseases
 Atherosclerosis Antibodies  >158 publications with PDGFRB and Atherosclerosis
 Necrosis Antibodies  >157 publications with PDGFRB and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Vascular Antibodies  >1309 publications with PDGFRB and Vascular
 Muscle Antibodies  >938 publications with PDGFRB and Muscle
 Blood Antibodies  >747 publications with PDGFRB and Blood
 Kidney Antibodies  >318 publications with PDGFRB and Kidney
 Lung Antibodies  >294 publications with PDGFRB and Lung
 Brain Antibodies  >290 publications with PDGFRB and Brain
 Liver Antibodies  >289 publications with PDGFRB and Liver
 Bone Antibodies  >289 publications with PDGFRB and Bone
 Embryonic Tissue Antibodies  >254 publications with PDGFRB and Embryonic Tissue
 Connective Tissue Antibodies  >175 publications with PDGFRB and Connective Tissue
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