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anti-PDI antibody :: Rabbit PDI Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS194487 anti-PDI antibody
Unit / Price
0.1 mL  /  $400 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

PDI, Polyclonal Antibody

 Also Known As   

Protein Disulfide Isomerase (PDI) Polyclonal Antibody

 Product Gene Name   

anti-PDI antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 17; NC_000017.10 (79801034..79818544, complement). Location: 17q25
 OMIM    176790
 3D Structure    ModBase 3D Structure for P07237
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, monkey, mouse, rat, hamster, bovine, ovine, porcine, canine, guinea pig, xenopus
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 Specificity    PDI
This antibody recognizes human, monkey, mouse, rat, hamster, bovine, ovine, porcine, canine, guinea pig, and Xenopus PDI.
 Form/Format    100ul whole antiserum
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 Antigen    Synthetic peptide derived from rat PDI conjugated to KLH.
 Preservative    None. Available on request.
 Dilution Instructions    Dilute in PBS or medium that is identical to that used in the assay system.
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 Preparation and Storage    Store frozen product at or below -20 degree C. For optimal storage, aliquot to smaller portions and store at -20 degree C to -70 degree C. Avoid repeated freeze/thaw cycles.
 Other Notes    Small volumes of anti-PDI antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-PDI antibody

   A microsomal enzyme known as Protein Disulfide Isomerase (PDI) is involved in the formation of disulfide bonds in many extracellular proteins through its oxidase and isomerase activities. It is also involved in the reduction of disulfide bonds in proteins. PDI is located primarily in the endoplasmic reticulum (ER) but may also be found in the cytosol. PDI can reside in the ER due to the highly conserved KDEL sequence at its carboxy terminus which serves as an ER-retention signal.
 Applications Tested/Suitable for anti-PDI antibody   

Immunohistochemistry; Immunoprecipitation; Immunoprecipitation; Western Blot; Immunocytochemistry

 Application Notes for anti-PDI antibody    Western blot: Use at 1:4,000 dilution. A band of approx. 58 kD is detected. Immunocytochemistry/Immunohistochemistry: Use at 2-5 ug/ml. Immunoprecipitation: Use at 10 ug/ml.
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NCBI/Uniprot data below describe general gene information for PDI. It may not necessarily be applicable to this product.
 NCBI GI #    13540806
 NCBI GeneID    5034
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 UniProt Primary Accession #    P07237 [Other Products]
 UniProt Secondary Accession #    P30037; P32079; Q15205; Q6LDE5; B2RDQ2 [Other Products]
 UniProt Related Accession #    P07237; Q8NI86; Q96C96 [Other Products]
 Molecular Weight    57,116 Da
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 NCBI Official Full Name    protein disulfide isomerase
 NCBI Official Synonym Full Names    prolyl 4-hydroxylase, beta polypeptide
 NCBI Official Symbol    P4HB [Similar Products]
 NCBI Official Synonym Symbols   
DSI; GIT; PDI; PHDB; PDIA1; PO4DB; PO4HB; PROHB; ERBA2L; P4Hbeta
[Similar Products]
 NCBI Protein Information    protein disulfide-isomerase; p55; OTTHUMP00000196834; protocollagen hydroxylase; prolyl 4-hydroxylase subunit beta; collagen prolyl 4-hydroxylase beta; thyroid hormone-binding protein p55; glutathione-insulin transhydrogenase; cellular thyroid hormone-binding protein; protein disulfide isomerase-associated 1; protein disulfide isomerase/oxidoreductase; protein disulfide isomerase family A, member 1; procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), beta polypeptide
 UniProt Protein Name    Protein disulfide-isomerase
 UniProt Synonym Protein Names   
Cellular thyroid hormone-binding protein; Prolyl 4-hydroxylase subunit beta; p55
 UniProt Gene Name    P4HB [Similar Products]
 UniProt Synonym Gene Names    ERBA2L; PDI; PDIA1; PO4DB [Similar Products]
 UniProt Entry Name    PDIA1_HUMAN
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 NCBI Summary for PDI    This gene encodes the beta subunit of prolyl 4-hydroxylase, a highly abundant multifunctional enzyme that belongs to the protein disulfide isomerase family. When present as a tetramer consisting of two alpha and two beta subunits, this enzyme is involved in hydroxylation of prolyl residues in preprocollagen. This enzyme is also a disulfide isomerase containing two thioredoxin domains that catalyze the formation, breakage and rearrangement of disulfide bonds. Other known functions include its ability to act as a chaperone that inhibits aggregation of misfolded proteins in a concentration-dependent manner, its ability to bind thyroid hormone, its role in both the influx and efflux of S-nitrosothiol-bound nitric oxide, and its function as a subunit of the microsomal triglyceride transfer protein complex. [provided by RefSeq]
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 UniProt Comments for PDI    PDIA1: This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations, functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, facilitates aggregation (anti-chaperone activity). May be involved with other chaperones in the structural modification of the TG precursor in hormone biogenesis. Also acts a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein MTTP. Homodimer. Monomers and homotetramers may also occur. Also constitutes the structural subunit of prolyl 4-hydroxylase and of the microsomal triacylglycerol transfer protein MTTP in mammalian cells. Stabilizes both enzymes and retain them in the ER without contributing to the catalytic activity. Binds UBQLN1. Binds to CD4, and upon HIV-1 binding to the cell membrane, is part of a P4HB/PDI-CD4-CXCR4-gp120 complex. Belongs to the protein disulfide isomerase family.

Protein type: Isomerase; Endoplasmic reticulum; Nuclear receptor co-regulator; EC 5.3.4.1; Oxidoreductase

Chromosomal Location of Human Ortholog: 17q25

Cellular Component: focal adhesion; endoplasmic reticulum lumen; endoplasmic reticulum; ER-Golgi intermediate compartment; melanosome; plasma membrane; extracellular region

Molecular Function: protein binding; enzyme binding; procollagen-proline 4-dioxygenase activity; protein heterodimerization activity; endopeptidase activity; protein disulfide isomerase activity

Biological Process: extracellular matrix organization and biogenesis; response to reactive oxygen species; protein folding; cell redox homeostasis; lipoprotein metabolic process; peptidyl-proline hydroxylation to 4-hydroxy-L-proline; proteolysis

Disease: Cole-carpenter Syndrome 1
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 Research Articles on PDI    1. Functional PDI is rapidly secreted from human umbilical vein endothelial cells in culture upon activation with thrombin or after laser-induced stimulation.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-PDI antibodyPathways associated with anti-PDI antibody
 Reference Product  PubMed Publications
 P4HA2 antibody  >1 publications with PDI and P4HA2
 ERO1L antibody  >1 publications with PDI and ERO1L
 Products by Pathway  Pathway Diagram
 Chylomicron-mediated Lipid Transport Pathway antibodies  Chylomicron-mediated Lipid Transport Pathway Diagram
 Lipid Digestion, Mobilization, And Transport Pathway antibodies  Lipid Digestion, Mobilization, And Transport Pathway Diagram
 Lipoprotein Metabolism Pathway antibodies  Lipoprotein Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Protein Processing In Endoplasmic Reticulum Pathway antibodies  Protein Processing In Endoplasmic Reticulum Pathway Diagram
 Protein Processing In Endoplasmic Reticulum Pathway antibodies  Protein Processing In Endoplasmic Reticulum Pathway Diagram
Diseases associated with anti-PDI antibodyOrgans/Tissues associated with anti-PDI antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >5 publications with PDI and Inflammation
 Neoplasms Antibodies  >4 publications with PDI and Neoplasms
 Melanoma Antibodies  >2 publications with PDI and Melanoma
 Heart Defects, Congenital Antibodies  >2 publications with PDI and Heart Defects, Congenital
 Congenital Abnormalities Antibodies  >2 publications with PDI and Congenital Abnormalities
 Nervous System Diseases Antibodies  >2 publications with PDI and Nervous System Diseases
 Neuroectodermal Tumors Antibodies  >2 publications with PDI and Neuroectodermal Tumors
 Fibrosis Antibodies  >2 publications with PDI and Fibrosis
 Genetic Diseases, Inborn Antibodies  >1 publications with PDI and Genetic Diseases, Inborn
 Ataxia Telangiectasia Antibodies  >1 publications with PDI and Ataxia Telangiectasia
 Organ/Tissue Name  Pubmed Publications
 Heart Antibodies  >9 publications with PDI and Heart
 Blood Antibodies  >8 publications with PDI and Blood
 Muscle Antibodies  >7 publications with PDI and Muscle
 Bone Antibodies  >4 publications with PDI and Bone
 Embryonic Tissue Antibodies  >4 publications with PDI and Embryonic Tissue
 Thyroid Antibodies  >2 publications with PDI and Thyroid
 Umbilical Cord Antibodies  >2 publications with PDI and Umbilical Cord
 Skin Antibodies  >1 publications with PDI and Skin
 Stomach Antibodies  >1 publications with PDI and Stomach
 Kidney Antibodies  >1 publications with PDI and Kidney
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