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anti-PDI antibody :: Rabbit PDI Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS247147
Unit / Price
0.05 mL  /  $530 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

PDI, Polyclonal Antibody

★Popular Item★
 Also Known As   

Rabbit Polyclonal to Rat PDI

 Product Synonym Names    Anti-PDI Antibody IHC-plus; PDI; Rat PDI
 Product Gene Name   

anti-PDI antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    176790
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Bovine, Dog, Xenopus, Guinea pig, Hamster, Human, Monkey, Mouse, Pig, Rat, Sheep
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 Specificity    Detects ~58 kD protein.
 Purity/Purification    Unpurified serum
 Form/Format    Antiserum
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 Target    PDI
 Target Species    Rat
 Immunogen Description    Rat PDI synthetic peptide conjugated to KLH.
 Immunogen Species    PDI antibody was raised against Rat
 Immunogen Type    Synthetic peptide - KLH conjugated
 Immunogen    PDI antibody was raised against rat PDI synthetic peptide conjugated to KLH.
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 Preparation and Storage    Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles.
 Other Notes    Small volumes of anti-PDI antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-PDI antibody   

Immunohistochemistry (IHC - Paraffin), Immunocytochemistry (ICC), Western Blot (WB), Immunoprecipitation (IP)

 Application Notes for anti-PDI antibody    ICC, IHC-P (1:100 - 1:250), IP, WB (1:4000)
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 Immunohistochemistry (IHC) of anti-PDI antibody    Anti-PDI antibody IHC of human tonsil, germinal center. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
anti-PDI antibody Immunohistochemistry (IHC) (IHC) image
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 Western Blot (WB) of anti-PDI antibody    PDI, Rat tissue.
anti-PDI antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for PDI. It may not necessarily be applicable to this product.
 NCBI GI #    2507460
 NCBI GeneID    5034
 NCBI Accession #    P07237.3 [Other Products]
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 UniProt Secondary Accession #    P30037; P32079; Q15205; Q6LDE5; B2RDQ2 [Other Products]
 UniProt Related Accession #    P07237 [Other Products]
 Molecular Weight    57,116 Da
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 NCBI Official Full Name    Protein disulfide-isomerase
 NCBI Official Synonym Full Names    prolyl 4-hydroxylase, beta polypeptide
 NCBI Official Symbol    P4HB [Similar Products]
 NCBI Official Synonym Symbols   
DSI; GIT; PDI; PHDB; PDIA1; PO4DB; PO4HB; PROHB; ERBA2L; P4Hbeta
[Similar Products]
 NCBI Protein Information    protein disulfide-isomerase; p55; protocollagen hydroxylase; prolyl 4-hydroxylase subunit beta; collagen prolyl 4-hydroxylase beta; thyroid hormone-binding protein p55; glutathione-insulin transhydrogenase; cellular thyroid hormone-binding protein; protein disulfide isomerase-associated 1; protein disulfide isomerase/oxidoreductase; protein disulfide isomerase family A, member 1; procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), beta polypeptide
 UniProt Protein Name    Protein disulfide-isomerase
 UniProt Synonym Protein Names   
Cellular thyroid hormone-binding protein; Prolyl 4-hydroxylase subunit beta; p55
 UniProt Gene Name    P4HB [Similar Products]
 UniProt Synonym Gene Names    ERBA2L; PDI; PDIA1; PO4DB; PDI [Similar Products]
 UniProt Entry Name    PDIA1_HUMAN
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 NCBI Summary for PDI    This gene encodes the beta subunit of prolyl 4-hydroxylase, a highly abundant multifunctional enzyme that belongs to the protein disulfide isomerase family. When present as a tetramer consisting of two alpha and two beta subunits, this enzyme is involved in hydroxylation of prolyl residues in preprocollagen. This enzyme is also a disulfide isomerase containing two thioredoxin domains that catalyze the formation, breakage and rearrangement of disulfide bonds. Other known functions include its ability to act as a chaperone that inhibits aggregation of misfolded proteins in a concentration-dependent manner, its ability to bind thyroid hormone, its role in both the influx and efflux of S-nitrosothiol-bound nitric oxide, and its function as a subunit of the microsomal triglyceride transfer protein complex. [provided by RefSeq, Jul 2008]
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 UniProt Comments for PDI    PDIA1: This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations, functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, facilitates aggregation (anti-chaperone activity). May be involved with other chaperones in the structural modification of the TG precursor in hormone biogenesis. Also acts a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein MTTP. Homodimer. Monomers and homotetramers may also occur. Also constitutes the structural subunit of prolyl 4-hydroxylase and of the microsomal triacylglycerol transfer protein MTTP in mammalian cells. Stabilizes both enzymes and retain them in the ER without contributing to the catalytic activity. Binds UBQLN1. Binds to CD4, and upon HIV-1 binding to the cell membrane, is part of a P4HB/PDI-CD4-CXCR4-gp120 complex. Belongs to the protein disulfide isomerase family.

Protein type: EC 5.3.4.1; Nuclear receptor co-regulator; Isomerase; Oxidoreductase; Endoplasmic reticulum

Chromosomal Location of Human Ortholog: 17q25

Cellular Component: focal adhesion; endoplasmic reticulum lumen; endoplasmic reticulum; ER-Golgi intermediate compartment; plasma membrane; extracellular region; melanosome

Molecular Function: protein binding; enzyme binding; procollagen-proline 4-dioxygenase activity; protein heterodimerization activity; endopeptidase activity; protein disulfide isomerase activity

Biological Process: response to reactive oxygen species; extracellular matrix organization and biogenesis; protein folding; cell redox homeostasis; lipoprotein metabolic process; peptidyl-proline hydroxylation to 4-hydroxy-L-proline; proteolysis

Disease: Cole-carpenter Syndrome 1
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 Research Articles on PDI    1. The crystal structure of the dimeric form of noncatalytic bb' domains of human PDIA1 determined to 2.3 A resolution revealed that the formation of dimers occludes the substrate binding site.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-PDI antibodyPathways associated with anti-PDI antibody
 Reference Product  PubMed Publications
 LEPRE1 antibody  >1 publications with PDI and LEPRE1
 COL1A1 antibody  >1 publications with PDI and COL1A1
 P4HA3 antibody  >1 publications with PDI and P4HA3
 LEPREL1 antibody  >1 publications with PDI and LEPREL1
 CALR antibody  >1 publications with PDI and CALR
 ERO1LB antibody  >1 publications with PDI and ERO1LB
 ERO1L antibody  >1 publications with PDI and ERO1L
 Products by Pathway  Pathway Diagram
 Cellular Responses To Stress Pathway antibodies  Cellular Responses To Stress Pathway Diagram
 Chylomicron-mediated Lipid Transport Pathway antibodies  Chylomicron-mediated Lipid Transport Pathway Diagram
 Collagen Biosynthesis And Modifying Enzymes Pathway antibodies  Collagen Biosynthesis And Modifying Enzymes Pathway Diagram
 Collagen Formation Pathway antibodies  Collagen Formation Pathway Diagram
 Detoxification Of Reactive Oxygen Species Pathway antibodies  Detoxification Of Reactive Oxygen Species Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Hedgehog Ligand Biogenesis Pathway antibodies  Hedgehog Ligand Biogenesis Pathway Diagram
 Lipid Digestion, Mobilization, And Transport Pathway antibodies  Lipid Digestion, Mobilization, And Transport Pathway Diagram
 Lipoprotein Metabolism Pathway antibodies  Lipoprotein Metabolism Pathway Diagram
Diseases associated with anti-PDI antibodyOrgans/Tissues associated with anti-PDI antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >7 publications with PDI and Nervous System Diseases
 Inflammation Antibodies  >6 publications with PDI and Inflammation
 Cardiovascular Diseases Antibodies  >3 publications with PDI and Cardiovascular Diseases
 Necrosis Antibodies  >3 publications with PDI and Necrosis
 Fibrosis Antibodies  >3 publications with PDI and Fibrosis
 Immune System Diseases Antibodies  >2 publications with PDI and Immune System Diseases
 Myocardial Ischemia Antibodies  >2 publications with PDI and Myocardial Ischemia
 Heart Diseases Antibodies  >1 publications with PDI and Heart Diseases
 Breast Neoplasms Antibodies  >1 publications with PDI and Breast Neoplasms
 Weight Gain Antibodies  >1 publications with PDI and Weight Gain
 Organ/Tissue Name  Pubmed Publications
 Vascular Antibodies  >20 publications with PDI and Vascular
 Blood Antibodies  >16 publications with PDI and Blood
 Heart Antibodies  >13 publications with PDI and Heart
 Muscle Antibodies  >8 publications with PDI and Muscle
 Bone Antibodies  >7 publications with PDI and Bone
 Embryonic Tissue Antibodies  >7 publications with PDI and Embryonic Tissue
 Connective Tissue Antibodies  >5 publications with PDI and Connective Tissue
 Bone Marrow Antibodies  >5 publications with PDI and Bone Marrow
 Lung Antibodies  >3 publications with PDI and Lung
 Umbilical Cord Antibodies  >3 publications with PDI and Umbilical Cord
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