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anti-PDLIM5 antibody :: Rabbit PDLIM5 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9125269
Unit / Price
0.05 mL  /  $230 +1 FREE 8GB USB
0.1 mL  /  $305 +1 FREE 8GB USB
0.2 mL  /  $460 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

PDLIM5, Polyclonal Antibody

★Popular Item★
 Also Known As   

PDLIM5 Polyclonal Antibody

 Product Synonym Names    L9; ENH; LIM; ENH1
 Product Gene Name   

anti-PDLIM5 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    605904
 3D Structure    ModBase 3D Structure for Q96HC4
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Affinity Purification
 Concentration    1mg/ml (lot specific)
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 Species    Human
 Immunogen    Recombinant Protein
 Immunogen    Recombinant protein of human PDLIM5
 Calculated Molecular Weight    63kDa
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 Preparation and Storage    Store at -20 degree C (regular) or -80 degree C (long term). Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
 Other Notes    Small volumes of anti-PDLIM5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-PDLIM5 antibody

   This gene encodes a member of a family of proteins that possess a 100-amino acid PDZ domain at the N terminus and one to three LIM domains at the C-terminus. This family member functions as a scaffold protein that tethers protein kinases to the Z-disk in striated muscles. It is thought to function in cardiomyocyte expansion and in restraining postsynaptic growth of excitatory synapses. Alternative splicing of this gene results in multiple transcript variants.
 Product Categories/Family for anti-PDLIM5 antibody    Polyclonal
 Applications Tested/Suitable for anti-PDLIM5 antibody   

Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

 Application Notes for anti-PDLIM5 antibody    WB: 1:500 - 1:2000
IHC: 1:50 - 1:200
IF: 1:50 - 1:200
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 Western Blot (WB) of anti-PDLIM5 antibody    Western blot analysis of extracts of various cell lines, using PDLIM5 antibody at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
anti-PDLIM5 antibody Western Blot (WB) (WB) image
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 Immunofluorescence (IF) of anti-PDLIM5 antibody    Immunofluorescence analysis of U2OS cells using PDLIM5 antibody. Blue: DAPI for nuclear staining.
anti-PDLIM5 antibody Immunofluorescence (IF) image
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NCBI/Uniprot data below describe general gene information for PDLIM5. It may not necessarily be applicable to this product.
 NCBI GI #    317373590
 NCBI GeneID    10611
 NCBI Accession #    Q96HC4.5 [Other Products]
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 UniProt Primary Accession #    Q96HC4 [Other Products]
 UniProt Secondary Accession #    O60705; Q56VN4; Q5UW38; Q8WVK0; A8K6F9; D6RB78; E9PBF5 [Other Products]
 UniProt Related Accession #    Q96HC4 [Other Products]
 Molecular Weight    596
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 NCBI Official Full Name    PDZ and LIM domain protein 5
 NCBI Official Synonym Full Names    PDZ and LIM domain 5
 NCBI Official Symbol    PDLIM5 [Similar Products]
 NCBI Official Synonym Symbols   
L9; ENH; LIM; ENH1
[Similar Products]
 NCBI Protein Information    PDZ and LIM domain protein 5; enigma homolog; enigma-like LIM domain protein; enigma-like PDZ and LIM domains protein
 UniProt Protein Name    PDZ and LIM domain protein 5
 UniProt Synonym Protein Names   
Enigma homolog; Enigma-like PDZ and LIM domains protein
 Protein Family    PDZ and LIM domain protein
 UniProt Gene Name    PDLIM5 [Similar Products]
 UniProt Synonym Gene Names    ENH [Similar Products]
 UniProt Entry Name    PDLI5_HUMAN
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 NCBI Summary for PDLIM5    This gene encodes a member of a family of proteins that possess a 100-amino acid PDZ domain at the N terminus and one to three LIM domains at the C-terminus. This family member functions as a scaffold protein that tethers protein kinases to the Z-disk in striated muscles. It is thought to function in cardiomyocyte expansion and in restraining postsynaptic growth of excitatory synapses. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012]
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 UniProt Comments for PDLIM5    LIM: an adaptor protein of the Enigma family. Contains three LIM domains and one PDZ domain. LIM domains are cysteine-rich double zinc fingers composed of 50 to 60 amino acids that are involved in protein-protein interactions. LIM domain-containing proteins are scaffolds for the formation of multiprotein complexes. The proteins are involved in cytoskeleton organization, cell lineage specification, organ development, and oncogenesis. Enigma family proteins possess a 100-amino acid PDZ domain in the N terminus and 1 to 3 LIM domains in the C terminus.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 4q22

Cellular Component: postsynaptic membrane; neuron projection; membrane; postsynaptic density; Z disc; cytosol; cell junction; actin cytoskeleton

Molecular Function: actinin binding; protein kinase C binding; zinc ion binding; protein N-terminus binding; actin binding

Biological Process: regulation of synaptogenesis
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 Research Articles on PDLIM5    1. It can be deduced that the nonsynonymous rs7690296 polymorphism of PDLIM5 could play an important role in the pathophysiology of both bipolar disorder and schizophrenia.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-PDLIM5 antibodyDiseases associated with anti-PDLIM5 antibody
 Reference Product  PubMed Publications
 PRKCG antibody  >1 publications with PDLIM5 and PRKCG
 CACNA1B antibody  >1 publications with PDLIM5 and CACNA1B
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >3 publications with PDLIM5 and Cardiovascular Diseases
 Heart Diseases Antibodies  >2 publications with PDLIM5 and Heart Diseases
 Cardiomyopathies Antibodies  >1 publications with PDLIM5 and Cardiomyopathies
 Nervous System Diseases Antibodies  >1 publications with PDLIM5 and Nervous System Diseases
 Hypertrophy Antibodies  >1 publications with PDLIM5 and Hypertrophy
 Cell Transformation, Neoplastic Antibodies  >1 publications with PDLIM5 and Cell Transformation, Neoplastic
 Breast Neoplasms Antibodies  >1 publications with PDLIM5 and Breast Neoplasms
 Fibrosis Antibodies  >1 publications with PDLIM5 and Fibrosis
 Carcinoma, Squamous Cell Antibodies  >1 publications with PDLIM5 and Carcinoma, Squamous Cell
 Lung Neoplasms Antibodies  >1 publications with PDLIM5 and Lung Neoplasms
Organs/Tissues associated with anti-PDLIM5 antibody
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >11 publications with PDLIM5 and Brain
 Blood Antibodies  >7 publications with PDLIM5 and Blood
 Nerve Antibodies  >4 publications with PDLIM5 and Nerve
 Prostate Antibodies  >4 publications with PDLIM5 and Prostate
 Muscle Antibodies  >4 publications with PDLIM5 and Muscle
 Heart Antibodies  >3 publications with PDLIM5 and Heart
 Thyroid Antibodies  >1 publications with PDLIM5 and Thyroid
 Mouth Antibodies  >1 publications with PDLIM5 and Mouth
 Lung Antibodies  >1 publications with PDLIM5 and Lung
 Uncharacterized Tissue Antibodies  >1 publications with PDLIM5 and Uncharacterized Tissue
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