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anti-PEG3 antibody :: Rabbit PEG3 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9215699 anti-PEG3 antibody
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 Product Name   

PEG3, Polyclonal Antibody

★Popular Item★
 Also Known As   

Rabbit Anti-PEG3 Polyclonal Antibody

 Product Synonym Names    Purified Rabbit Polyclonal Antibody (Pab); PW1; ZNF94; ZSCAN24; ZKSCAN22; Paternally-expressed gene 3 protein; Zinc finger and SCAN domain-containing protein 24; PEG3; KIAA287
 Product Gene Name   

anti-PEG3 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    601483
 3D Structure    ModBase 3D Structure for Q9GZU2
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Form/Format    0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
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 Antigen Source    KLH conjugated synthetic peptide derived from Human PEG3
 Antigen Type    Synthetic Peptide
 Cellular Location    Nucleus {ECO:0000255|PROSITEProRule:PRU00187}. Cytoplasm
 Tissue Location    Brain, glial cells, astrocytes, embryo, placenta, testis, ovary and uterus. In the placenta it is found in the layer of villous cytotrophoblast cells while in the ovary it is found in the cells of the ovarian stroma including the thecal layers around the follicles. Expression is highly repressed in glioma cell lines.
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 Preparation and Storage    Shipped at 4 degree C. Store at -20 degree C (Avoid repeated freeze/thaw cycles).
 Other Notes    Small volumes of anti-PEG3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-PEG3 antibody

   Induces apoptosis in cooperation with SIAH1A. Acts as a mediator between p53/TP53 and BAX in a neuronal death pathway that is activated by DNA damage. Acts synergistically with TRAF2 and inhibits TNF induced apoptosis through activation of NF-kappa-B (By similarity). Possesses a tumor suppressing activity in glioma cells.
 Applications Tested/Suitable for anti-PEG3 antibody   

Immunohistochemistry (IHC) Paraffin

 Application Notes for anti-PEG3 antibody    IHC-P: ~1:100~1:500
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NCBI/Uniprot data below describe general gene information for PEG3. It may not necessarily be applicable to this product.
 NCBI GI #    226053126
 NCBI GeneID    5178
 NCBI Accession #    NP_001139656.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001146184.1 [Other Products]
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 UniProt Primary Accession #    Q9GZU2 [Other Products]
 UniProt Secondary Accession #    P78418; Q5H9P9; Q7Z7H7; Q8TF75; Q9GZY2; A7E2B8; B4DIM4; C9JP50 [Other Products]
 UniProt Related Accession #    Q9GZU2 [Other Products]
 Molecular Weight    180827
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 NCBI Official Full Name    paternally-expressed gene 3 protein isoform 1
 NCBI Official Synonym Full Names    paternally expressed 3
 NCBI Official Symbol    PEG3 [Similar Products]
 NCBI Official Synonym Symbols   
PW1; ZNF904; ZSCAN24; ZKSCAN22
[Similar Products]
 NCBI Protein Information    paternally-expressed gene 3 protein
 UniProt Protein Name    Paternally-expressed gene 3 protein
 UniProt Synonym Protein Names   
Zinc finger and SCAN domain-containing protein 24
 Protein Family    Paternally-expressed gene 3 protein
 UniProt Gene Name    PEG3 [Similar Products]
 UniProt Synonym Gene Names    KIAA0287; ZSCAN24 [Similar Products]
 UniProt Entry Name    PEG3_HUMAN
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 NCBI Summary for PEG3    In human, ZIM2 and PEG3 are treated as two distinct genes though they share multiple 5' exons and a common promoter and both genes are paternally expressed (PMID:15203203). Alternative splicing events connect their shared 5' exons either with the remaining 4 exons unique to ZIM2, or with the remaining 2 exons unique to PEG3. In contrast, in other mammals ZIM2 does not undergo imprinting and, in mouse, cow, and likely other mammals as well, the ZIM2 and PEG3 genes do not share exons. Human PEG3 protein belongs to the Kruppel C2H2-type zinc finger protein family. PEG3 may play a role in cell proliferation and p53-mediated apoptosis. PEG3 has also shown tumor suppressor activity and tumorigenesis in glioma and ovarian cells. Alternative splicing of this PEG3 gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Sep 2009]
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 UniProt Comments for PEG3    PEG3: Induces apoptosis in cooperation with SIAH1A. Acts as a mediator between p53/TP53 and BAX in a neuronal death pathway that is activated by DNA damage. Acts synergistically with TRAF2 and inhibits TNF induced apoptosis through activation of NF-kappa-B. Possesses a tumor suppressing activity in glioma cells. Belongs to the krueppel C2H2-type zinc-finger protein family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding; C2H2-type zinc finger protein; Transcription factor

Chromosomal Location of Human Ortholog: 19q13.4

Cellular Component: nucleoplasm; cytoplasm; nucleus

Molecular Function: nucleic acid binding; metal ion binding

Biological Process: transcription, DNA-dependent; apoptosis; negative regulation of transcription from RNA polymerase II promoter
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 Research Articles on PEG3    1. The PEG3-SCAN domain appears to constitute an assembly block, enabling PEG3 homo- or heterodimerization to control gene expression in a combinatorial fashion.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-PEG3 antibodyPathways associated with anti-PEG3 antibody
 Reference Product  PubMed Publications
 PEG10 antibody  >21 publications with PEG3 and PEG10
 USP29 antibody  >10 publications with PEG3 and USP29
 BECN1 antibody  >4 publications with PEG3 and BECN1
 CDC25B antibody  >3 publications with PEG3 and CDC25B
 TP53 antibody  >3 publications with PEG3 and TP53
 TRAF2 antibody  >2 publications with PEG3 and TRAF2
 SIAH1 antibody  >2 publications with PEG3 and SIAH1
 SIAH2 antibody  >1 publications with PEG3 and SIAH2
 Products by Pathway  Pathway Diagram
 TNF-alpha/NF-kB Signaling Pathway antibodies  TNF-alpha/NF-kB Signaling Pathway Diagram
Diseases associated with anti-PEG3 antibodyOrgans/Tissues associated with anti-PEG3 antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >20 publications with PEG3 and Nervous System Diseases
 Inflammation Antibodies  >9 publications with PEG3 and Inflammation
 Necrosis Antibodies  >6 publications with PEG3 and Necrosis
 Infertility, Male Antibodies  >6 publications with PEG3 and Infertility, Male
 Breast Neoplasms Antibodies  >6 publications with PEG3 and Breast Neoplasms
 Fetal Growth Retardation Antibodies  >5 publications with PEG3 and Fetal Growth Retardation
 Prenatal Exposure Delayed Effects Antibodies  >5 publications with PEG3 and Prenatal Exposure Delayed Effects
 Prenatal Injuries Antibodies  >5 publications with PEG3 and Prenatal Injuries
 Craniofacial Abnormalities Antibodies  >4 publications with PEG3 and Craniofacial Abnormalities
 Atrophy Antibodies  >4 publications with PEG3 and Atrophy
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >60 publications with PEG3 and Brain
 Placenta Antibodies  >32 publications with PEG3 and Placenta
 Muscle Antibodies  >26 publications with PEG3 and Muscle
 Embryonic Tissue Antibodies  >25 publications with PEG3 and Embryonic Tissue
 Liver Antibodies  >23 publications with PEG3 and Liver
 Lung Antibodies  >15 publications with PEG3 and Lung
 Testis Antibodies  >11 publications with PEG3 and Testis
 Ovary Antibodies  >11 publications with PEG3 and Ovary
 Kidney Antibodies  >10 publications with PEG3 and Kidney
 Prostate Antibodies  >8 publications with PEG3 and Prostate
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