NP_001091980.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
35,339 Da
NCBI Official Full Name
E3 ubiquitin-protein ligase pellino homolog 3 isoform 2
NCBI Official Synonym Full Names
pellino E3 ubiquitin protein ligase family member 3
NCBI Protein Information
E3 ubiquitin-protein ligase pellino homolog 3
UniProt Protein Name
E3 ubiquitin-protein ligase pellino homolog 3
UniProt Synonym Gene Names
UniProt Entry Name
PELI3_HUMAN
NCBI Summary for PELI3
The protein encoded by this gene is a scaffold protein and an intermediate signaling protein in the innate immune response pathway. The encoded protein helps transmit the immune response signal from Toll-like receptors to IRAK1/TRAF6 complexes. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011]
UniProt Comments for PELI3
PELI3: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates 'Lys-63'-linked polyubiquitination of IRAK1. Can activate AP1/JUN and ELK1. Not required for NF-kappa-B activation. Belongs to the pellino family. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 6.3.2.19; Ubiquitin ligase; Adaptor/scaffold; Ligase; Ubiquitin conjugating system; EC 6.3.2.-
Chromosomal Location of Human Ortholog: 11q13.2
Cellular Component: cytosol
Molecular Function: protein binding
Research Articles on PELI3
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Pathways associated with anti-PELI3 antibody
Diseases associated with anti-PELI3 antibody
Organs/Tissues associated with anti-PELI3 antibody
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