Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Antibody rightarrow PEN2 rightarrow Polyclonal PEN2  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • CDH19 Antibody
 • EID1 Antibody
 • ACAT1 Antibody
 • Chemokine C-C-Motif Receptor Like Protein 1 (CCRL1) ELISA Kit
 • CXC-Chemokine Ligand 16 (CXCL16) ELISA Kit
 • Intercellular Adhesion Molecule 2 (ICAM-2) ELISA Kit
 • Interleukin 34 (IL-34) ELISA Kit
 • Inhibin Binding Protein (INHBP) ELISA Kit
 • Nicotinamide Adenine Dinucleotide Phosphate Oxidase 4 (NOX4) ELISA Kit
 • Tartrate Resistant Acid Phosphatase 5B (TRACP-5B) ELISA Kit
 • Platelet Membrane Glycoprotein 2B3A-Cd41+Cd61 (GPIIBIIIA-CD4... ELISA Kit
 • Methotrexate (MTX) ELISA Kit
 • Signal Recognition Particle Antibody (SRP) ELISA Kit
 • Speckle-Type Poz Protein (SPOP) ELISA Kit
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

anti-PEN2 antibody :: Rabbit anti-Mouse, Rat PEN2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS221484
Unit / Price
0.1 mg  /  $410 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

PEN2, Polyclonal Antibody

 Also Known As   

RABBIT ANTI HUMAN PEN2 (C-TERMINAL)

 Product Gene Name   

anti-PEN2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 OMIM    607632
 3D Structure    ModBase 3D Structure for Q9NZ42
Section Bar
 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Mouse, Rat
Section Bar
 Specificity    This item recognises Presenilin enhancer protein 2 (PEN), a 12 kDa member of the PEN2 family and subunit of the gamma-secretase complex. This complex is an endoprotease that cleaves integral membrane proteins. These include Notch receptors and the beta-amyloid precursor protein which is cleaved to form amyloid beta peptide, a major component of the neuritic plaques found in Alzheimer's disease. The gamma secretase complex consists of nicastrin, the presenilin homodimers and APH1. It is the addition of PEN2, the final stage of gamma secretase maturation that facilitates endoproteolysis of presenilin and confers proteolytic activity. PEN2 expression has been observed in leukocytes, lung, placenta, small intestine, liver, kidney, spleen thymus, skeletal muscle, heart and brain.
 Form/Format    Purified
Purified IgG - liquid
 Concentration    IgG concentration 1.0mg/ml (lot specific)
Section Bar
 Perservative Stabilisers    0.02% Sodium Azide
 Immunogen    13 amino acid peptide sequence near the carboxy terminus of human PEN2.
Buffer Solution
 Antiserum Preparation    Antisera to human PEN2 were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.
 Target Species    Human
Section Bar
 Preparation and Storage    Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
 Other Notes    Small volumes of anti-PEN2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 

Product Description specifically for anti-PEN2 antibody

   MBS221484 recognises Presenilin enhancer protein 2 (PEN), a 12 kDa member of the PEN2 family and subunit of the gamma-secretase complex. This complex is an endoprotease that cleaves integral membrane proteins. These include Notch receptors and the beta-amyloid precursor protein which is cleaved to form amyloid beta peptide, a major component of the neuritic plaques found in Alzheimer's disease. The gamma secretase complex consists of nicastrin, the presenilin homodimers and APH1. It is the addition of PEN2, the final stage of gamma secretase maturation that facilitates endoproteolysis of presenilin and confers proteolytic activity. PEN2 expression has been observed in leukocytes, lung, placenta, small intestine, liver, kidney, spleen thymus, skeletal muscle, heart and brain.
 Applications Tested/Suitable for anti-PEN2 antibody   

Immunofluorescence (IF), Western Blot (WB)

 Application Notes for anti-PEN2 antibody    Western Blot: This item detects a band of approximately 12kDa in K562
Western Blotting: Minimum Dilution: 0.5; Maximum Dilution: 1.0ug/ml
Section Bar
 Testing Data #1 of anti-PEN2 antibody    Western blot analysis of whole cell lysates from K562 human erythromyeloblastoid cells probed with Rabbit anti Human PEN2 MBS221484) at 0.5(A), 1(B) and 2(C) ug/ml
anti-PEN2 antibody Testing Data #1 image
Section Bar
 Testing Data #2 of anti-PEN2 antibody    Immunofluorescence of K562 cells with Rabbit anti PEN2 (MBS221484)
anti-PEN2 antibody Testing Data #2 image
Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for PEN2. It may not necessarily be applicable to this product.
 NCBI GI #    528281416
 NCBI GeneID    55851
 NCBI Accession #    NP_001268461.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001281532.1 [Other Products]
Section Bar
 UniProt Primary Accession #    Q9NZ42 [Other Products]
 UniProt Secondary Accession #    B2R5L9 [Other Products]
 UniProt Related Accession #    Q9NZ42 [Other Products]
 Molecular Weight    12,029 Da
Table BarTOPTable Bar
 NCBI Official Full Name    gamma-secretase subunit PEN-2
 NCBI Official Synonym Full Names    presenilin enhancer gamma secretase subunit
 NCBI Official Symbol    PSENEN [Similar Products]
 NCBI Official Synonym Symbols   
PEN2; PEN-2; MDS033; MSTP064
[Similar Products]
 NCBI Protein Information    gamma-secretase subunit PEN-2; hematopoietic stem/progenitor cells protein MDS033; presenilin enhancer 2 homolog
 UniProt Protein Name    Gamma-secretase subunit PEN-2
 UniProt Synonym Protein Names   
Presenilin enhancer protein 2
 UniProt Gene Name    PSENEN [Similar Products]
 UniProt Synonym Gene Names    PEN2 [Similar Products]
 UniProt Entry Name    PEN2_HUMAN
Section Bar
 NCBI Summary for PEN2    Presenilins, which are components of the gamma-secretase protein complex, are required for intramembranous processing of some type I transmembrane proteins, such as the Notch proteins and the beta-amyloid precursor protein. Signaling by Notch receptors mediates a wide range of developmental cell fates. Processing of the beta-amyloid precursor protein generates neurotoxic amyloid beta peptides, the major component of senile plaques associated with Alzheimer's disease. This gene encodes a protein that is required for Notch pathway signaling, and for the activity and accumulation of gamma-secretase. Mutations resulting in haploinsufficiency for this gene cause familial acne inversa-2 (ACNINV2). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Section Bar
 UniProt Comments for PEN2    PSENEN: Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta- amyloid precursor protein). Probably represents the last step of maturation of gamma-secretase, facilitating endoproteolysis of presenilin and conferring gamma-secretase activity. Component of the gamma-secretase complex, a complex composed of a presenilin homodimer (PSEN1 or PSEN2), nicastrin (NCSTN), APH1 (APH1A or APH1B) and PSENEN/PEN2. Such minimal complex is sufficient for secretase activity, although other components may exist. Widely expressed. Expressed in leukocytes, lung, placenta, small intestine, liver, kidney, spleen thymus, skeletal muscle, heart and brain. Belongs to the PEN-2 family.

Protein type: Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 19q13.12

Cellular Component: Golgi apparatus; endoplasmic reticulum membrane; endoplasmic reticulum; integral to plasma membrane; plasma membrane

Molecular Function: protein binding

Biological Process: positive regulation of catalytic activity; axon guidance; amyloid precursor protein catabolic process; Notch signaling pathway; membrane protein intracellular domain proteolysis; nerve growth factor receptor signaling pathway; positive regulation of apoptosis; membrane protein ectodomain proteolysis; ephrin receptor signaling pathway; Notch receptor processing; protein processing

Disease: Acne Inversa, Familial, 2
Table BarTOPTable Bar
 Research Articles on PEN2    1. Recombinant human Pen-2 fusion protein was purified from bacteria to >95% purity.
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with anti-PEN2 antibodyPathways associated with anti-PEN2 antibody
 Reference Product  PubMed Publications
 PSEN1 antibody  >52 publications with PEN2 and PSEN1
 APH1A antibody  >41 publications with PEN2 and APH1A
 PSEN2 antibody  >13 publications with PEN2 and PSEN2
 NCSTN antibody  >7 publications with PEN2 and NCSTN
 NOTCH1 antibody  >1 publications with PEN2 and NOTCH1
 Products by Pathway  Pathway Diagram
 Activated NOTCH1 Transmits Signal To The Nucleus Pathway antibodies  Activated NOTCH1 Transmits Signal To The Nucleus Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimers Disease Pathway antibodies  Alzheimers Disease Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Cell Death Signalling Via NRAGE, NRIF And NADE Pathway antibodies  Cell Death Signalling Via NRAGE, NRIF And NADE Pathway Diagram
 Constitutive Signaling By NOTCH1 HD+PEST Domain Mutants Pathway antibodies  Constitutive Signaling By NOTCH1 HD+PEST Domain Mutants Pathway Diagram
 Constitutive Signaling By NOTCH1 PEST Domain Mutants Pathway antibodies  Constitutive Signaling By NOTCH1 PEST Domain Mutants Pathway Diagram
 Delta-Notch Signaling Pathway antibodies  Delta-Notch Signaling Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
Diseases associated with anti-PEN2 antibodyOrgans/Tissues associated with anti-PEN2 antibody
 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >1 publications with PEN2 and Breast Neoplasms
 Necrosis Antibodies  >1 publications with PEN2 and Necrosis
 Hidradenitis suppurativa, familial Antibodies  >1 publications with PEN2 and Hidradenitis suppurativa, familial
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >15 publications with PEN2 and Brain
 Pharynx Antibodies  >11 publications with PEN2 and Pharynx
 Skin Antibodies  >4 publications with PEN2 and Skin
 Kidney Antibodies  >3 publications with PEN2 and Kidney
 Bone Antibodies  >1 publications with PEN2 and Bone
 Embryonic Tissue Antibodies  >1 publications with PEN2 and Embryonic Tissue
 Ovary Antibodies  >1 publications with PEN2 and Ovary
 Uncharacterized Tissue Antibodies  >1 publications with PEN2 and Uncharacterized Tissue
 Testis Antibodies  >1 publications with PEN2 and Testis
 Connective Tissue Antibodies  >1 publications with PEN2 and Connective Tissue
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions