Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Antibody rightarrow PER3 rightarrow Polyclonal PER3  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • Alpha Fetoprotein (AFP) Antibody
 • Adenovirus (ADV-Ag) ELISA Kit
 • enhancer of zeste homolog 2 (Drosophila) (EZH2) ELISA Kit
 • DHT ELISA Kit
 • Protein Tyrosine Phosphatase Receptor Type B (PTPRB) Recombinant Protein
 • Glial fibrillary acidic protein (GFAP) Recombinant Protein
 • Motilin (MTL) ELISA Kit
 • NFH Antibody
 • GLI1 Antibody
 • Wingless-Type Mmtv Integration Site Family, Member 9B (WNT9B... ELISA Kit
 • E3 ubiquitin-protein ligase CBL-B (Cblb) ELISA Kit
 • 6-phosphogluconolactonase (PGLS) Recombinant Protein
 • stromal cell-derived factor 2-like 1 (SDF2L1) Antibody
 • gamma-aminobutyric acid (GABA) A receptor, beta 2 (GABRB2) ELISA Kit
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

anti-PER3 antibody :: Rabbit anti-Human, Mouse PER3 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS7052237
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

PER3, Polyclonal Antibody

★Popular Item★
 Also Known As   

PER3 Antibody

 Product Synonym Names    Period circadian protein homolog 3; hPER3; Cell growth-inhibiting gene 13 protein; Circadian clock protein PERIOD 3; PER3; GIG13
 Product Gene Name   

anti-PER3 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 OMIM    AB047521 Genomic DNA
 3D Structure    ModBase 3D Structure for P56645
Section Bar
 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse
Section Bar
 Purity/Purification    >95%, Protein G purified
 Form/Format    Liquid
Section Bar
 Immunogen    Recombinant Human Period circadian protein homolog 3 protein (1-131AA)
 Conjugation    Non-conjugated
 Preservative    0.03% Proclin 300
 Constituents    50% Glycerol, 0.01M PBS, pH 7.4
Section Bar
 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-PER3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 

Related Product Information for anti-PER3 antibody

   Originally described as a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, ARNTL/BMAL1, ARNTL2/BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and ARNTL/BMAL1 or ARNTL2/BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-ARNTL/BMAL1|ARNTL2/BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1, NR1D2, RORA, RORB and RORG, which form a second feedback loop and which activate and repress ARNTL/BMAL1 transcription, respectively. Has a redundant role with the other PER proteins PER1 and PER2 and is not essential for the circadian rhythms maintenance. In contrast, plays an important role in sleep-wake timing and sleep homeostasis probably through the transcriptional regulation of sleep homeostasis-related genes, without influencing circadian parameters. Can bind heme.
 Applications Tested/Suitable for anti-PER3 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

 Application Notes for anti-PER3 antibody    WB: 1:500-1:5000
IHC: 1:20-1:200
IF: 1:50-1:200
Section Bar
 Western Blot (WB) of anti-PER3 antibody    Western Blot
Positive WB detected in: Hela whole cell lysate,Mouse skeletal muscle tissue
All lanes: PER3 antibody at 4ug/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 132,133 KDa
Observed band size: 132 KDa

anti-PER3 antibody Western Blot (WB) (WB) image
Section Bar
 Immunohistochemistry (IHC) of anti-PER3 antibody    Immunohistochemistry of paraffin-embedded human ovarian cancer using MBS7052237 at dilution of 1:100
anti-PER3 antibody Immunohistochemistry (IHC) (IHC) image
Section Bar
 Immunohistochemistry (IHC) of anti-PER3 antibody    Immunohistochemistry of paraffin-embedded human colon cancer using MBS7052237 at dilution of 1:100
anti-PER3 antibody Immunohistochemistry (IHC) (IHC) image
Section Bar
 Immunofluorescence (IF) of anti-PER3 antibody    Immunofluorescent analysis of Hela cells using MBS7052237 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
anti-PER3 antibody Immunofluorescence (IF) image
Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for PER3. It may not necessarily be applicable to this product.
 NCBI GI #    577861064
 NCBI GeneID    8863
 NCBI Accession #    NP_001276790.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001289861.1 [Other Products]
Section Bar
 UniProt Primary Accession #    P56645 [Other Products]
 UniProt Secondary Accession #    Q5H8X4; Q5H8X5; Q969K6; Q96S77; Q96S78; Q9C0J3; Q9NSP9; Q9UGU8 [Other Products]
 UniProt Related Accession #    P56645 [Other Products]
 Molecular Weight    132,660 Da
Table BarTOPTable Bar
 NCBI Official Full Name    period circadian protein homolog 3 isoform 2
 NCBI Official Synonym Full Names    period circadian clock 3
 NCBI Official Symbol    PER3 [Similar Products]
 NCBI Official Synonym Symbols   
GIG13; FASPS3
[Similar Products]
 NCBI Protein Information    period circadian protein homolog 3
 UniProt Protein Name    Period circadian protein homolog 3
 UniProt Synonym Protein Names   
Cell growth-inhibiting gene 13 protein; Circadian clock protein PERIOD 3
 Protein Family    Period circadian protein
 UniProt Gene Name    PER3 [Similar Products]
 UniProt Synonym Gene Names    hPER3 [Similar Products]
Section Bar
 NCBI Summary for PER3    This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene have been linked to sleep disorders. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2014]
Section Bar
 UniProt Comments for PER3    PER3: Component of the circadian clock mechanism which is essential for generating circadian rhythms. Can bind heme. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Unknown function

Chromosomal Location of Human Ortholog: 1p36.23

Cellular Component: cytoplasm; nucleus

Molecular Function: protein binding

Biological Process: negative regulation of transcription from RNA polymerase II promoter; protein stabilization; regulation of circadian sleep/wake cycle, sleep

Disease: Advanced Sleep Phase Syndrome, Familial, 3
Table BarTOPTable Bar
 Research Articles on PER3    1. PER3 variants may be associated with decreased risk for depressive symptoms, including subthreshold levels of depressive symptoms, in older adults.
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with anti-PER3 antibodyPathways associated with anti-PER3 antibody
 Reference Product  PubMed Publications
 CLOCK antibody  >183 publications with PER3 and CLOCK
 PER2 antibody  >146 publications with PER3 and PER2
 PER1 antibody  >129 publications with PER3 and PER1
 CRY1 antibody  >54 publications with PER3 and CRY1
 CRY2 antibody  >50 publications with PER3 and CRY2
 ARNTL antibody  >47 publications with PER3 and ARNTL
 CSNK1E antibody  >6 publications with PER3 and CSNK1E
 SP1 antibody  >1 publications with PER3 and SP1
 CSNK1D antibody  >1 publications with PER3 and CSNK1D
 Products by Pathway  Pathway Diagram
 Circadian Rhythm - Mammal Pathway antibodies  Circadian Rhythm - Mammal Pathway Diagram
 Circadian Rhythm - Mammal Pathway antibodies  Circadian Rhythm - Mammal Pathway Diagram
 Herpes Simplex Infection Pathway antibodies  Herpes Simplex Infection Pathway Diagram
 Herpes Simplex Infection Pathway antibodies  Herpes Simplex Infection Pathway Diagram
Diseases associated with anti-PER3 antibodyOrgans/Tissues associated with anti-PER3 antibody
 Disease Name  Pubmed Publications
 Mental Disorders Antibodies  >41 publications with PER3 and Mental Disorders
 Nervous System Diseases Antibodies  >32 publications with PER3 and Nervous System Diseases
 Neoplasms Antibodies  >27 publications with PER3 and Neoplasms
 Disease Models, Animal Antibodies  >7 publications with PER3 and Disease Models, Animal
 Inflammation Antibodies  >6 publications with PER3 and Inflammation
 Necrosis Antibodies  >5 publications with PER3 and Necrosis
 Central Nervous System Diseases Antibodies  >5 publications with PER3 and Central Nervous System Diseases
 Cardiovascular Diseases Antibodies  >5 publications with PER3 and Cardiovascular Diseases
 Skin Diseases Antibodies  >5 publications with PER3 and Skin Diseases
 Brain Diseases Antibodies  >5 publications with PER3 and Brain Diseases
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >65 publications with PER3 and Brain
 Eye Antibodies  >40 publications with PER3 and Eye
 Liver Antibodies  >19 publications with PER3 and Liver
 Muscle Antibodies  >18 publications with PER3 and Muscle
 Heart Antibodies  >13 publications with PER3 and Heart
 Pineal Gland Antibodies  >12 publications with PER3 and Pineal Gland
 Vascular Antibodies  >6 publications with PER3 and Vascular
 Kidney Antibodies  >5 publications with PER3 and Kidney
 Connective Tissue Antibodies  >4 publications with PER3 and Connective Tissue
 Lung Antibodies  >4 publications with PER3 and Lung
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions