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anti-Perp antibody :: Rabbit anti-Human PERP Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS151420
Unit / Price
0.02 mg  /  $140 +1 FREE 8GB USB
0.1 mg  /  $355 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

PERP, Polyclonal Antibody

★Popular Item★
 Also Known As   

PERP Antibody

 Product Synonym Names    PERP; THW; KCP1; PIGPC1; KRTCAP1; 1110017A08Rik; Krtcap1; p53 apoptosis effector related to PMP-22; Keratinocyte-associated protein 1; KCP-1; PERP, TP53 apoptosis effector
 Product Gene Name   

anti-Perp antibody

[Similar Products]
 Antibody/Peptide Pairs    PERP peptide (MBS152034) is used for blocking the activity of PERP antibody (MBS151420)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for Q9JK95
 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    PERP Antibody is Antibody is DEAE purified.
 Form/Format    Liquid
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 Conjugate    Unconjugated
 Immunogen    PERP antibody was raised against a synthetic peptide corresponding to amino acids near the carboxy terminus of human PERP, which differ from the mouse sequence by three amino acids.
 Buffer    PERP Antibody is supplied in PBS containing 0.02% sodium azide.
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 Preparation and Storage    PERP antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
 Other Notes    Small volumes of anti-Perp antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-Perp antibody

   PERP Antibody: The p53 tumor-suppressor gene integrates numerous signals that control cell life and death. Several novel molecules involved in p53 network, including Chk2, p53R2, p53AIP1, Noxa, PIDD, PID/MTA2, MTBP and PERP, were identified and their genes were cloned recently. PERP, also termed PIGPC1 and THW, is a plasma membrane protein. p53 binds to the promoter of PERP and transcriptionally activates PERP gene then the translated PERP protein mediates the p53 induced apoptosis. The expression of PERP causes cell death. PERP is a mediator of p53 induced apoptosis. PERP has sequence similarity to PMP-22/gas3 and is a new member of the PMP-22/gas3 family.
 Applications Tested/Suitable for anti-Perp antibody   

ELISA (EIA), Western Blot (WB), Immunocytochemistry (ICC)

 Application Notes for anti-Perp antibody    PERP antibody can be used for detection of PERP by Western blot at 1 mug/mL. A 21 kDa band can be detected. Antibody can also be used for immunocytochemistry starting at 10 mug/mL.
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 Western Blot (WB) of anti-Perp antibody    Western blot analysis of PERP expression in A431 whole cell lysates in the absence (A) and presence (B) of blocking peptide with PERP antibody at 1 μg /ml.
anti-Perp antibody Western Blot (WB) (WB) image
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 Immunocytochemistry (ICC) of anti-Perp antibody    Immunocytochemistry of PERP in A431 cells with PERP antibody at 10 μg/mL.
anti-Perp antibody Immunocytochemistry (ICC) (ICC) image
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NCBI/Uniprot data below describe general gene information for Perp. It may not necessarily be applicable to this product.
 NCBI GI #    11528520
 NCBI GeneID    64058
 NCBI Accession #    NP_071315 [Other Products]
 NCBI GenBank Nucleotide #    NM_022032.4 [Other Products]
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 UniProt Primary Accession #    Q9JK95 [Other Products]
 UniProt Secondary Accession #    Q9JI77 [Other Products]
 UniProt Related Accession #    Q9JK95 [Other Products]
 Molecular Weight    21 kDa
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 NCBI Official Full Name    p53 apoptosis effector related to PMP-22
 NCBI Official Synonym Full Names    PERP, TP53 apoptosis effector
 NCBI Official Symbol    Perp [Similar Products]
 NCBI Official Synonym Symbols   
THW; KCP1; PIGPC1; KRTCAP1; 1110017A08Rik
[Similar Products]
 NCBI Protein Information    p53 apoptosis effector related to PMP-22; KCP-1; p53 apoptosis-associated target; keratinocyte-associated protein 1; p53 apoptosis effector related to Pmp22
 UniProt Protein Name    p53 apoptosis effector related to PMP-22
 UniProt Synonym Protein Names   
Keratinocyte-associated protein 1; KCP-1
 Protein Family    Perphorin
 UniProt Gene Name    Perp [Similar Products]
 UniProt Synonym Gene Names    Krtcap1; KCP-1 [Similar Products]
 UniProt Entry Name    PERP_MOUSE
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 UniProt Comments for Perp    PERP: Component of intercellular desmosome junctions. Plays a role in stratified epithelial integrity and cell-cell adhesion by promoting desmosome assembly. Plays a role as an effector in the TP53-dependent apoptotic pathway. Belongs to the TMEM47 family.

Protein type: Membrane protein, multi-pass; Mitochondrial; Cell adhesion; Membrane protein, integral

Cellular Component: Golgi apparatus; mitochondrion; membrane; integral to plasma membrane; integral to membrane; plasma membrane; cell junction

Biological Process: heterotypic cell-cell adhesion; apoptosis; positive regulation of proteolysis; cell adhesion
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 Research Articles on Perp    1. an important role for Perp in normal mammary tissue function and in mammary cancer suppression
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-Perp antibodyDiseases associated with anti-Perp antibody
 Products by Pathway  Pathway Diagram
 PluriNetWork Pathway antibodies  PluriNetWork Pathway Diagram
 P53 Signaling Pathway antibodies  P53 Signaling Pathway Diagram
 P53 Signaling Pathway antibodies  P53 Signaling Pathway Diagram
 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >13 publications with Perp and Carcinoma
 Adenocarcinoma Antibodies  >6 publications with Perp and Adenocarcinoma
 Cell Transformation, Neoplastic Antibodies  >4 publications with Perp and Cell Transformation, Neoplastic
 Heart Diseases Antibodies  >4 publications with Perp and Heart Diseases
 Esophageal Neoplasms Antibodies  >4 publications with Perp and Esophageal Neoplasms
 Inflammation Antibodies  >4 publications with Perp and Inflammation
 Skin Neoplasms Antibodies  >4 publications with Perp and Skin Neoplasms
 Breast Neoplasms Antibodies  >4 publications with Perp and Breast Neoplasms
 Liver Diseases Antibodies  >4 publications with Perp and Liver Diseases
 Liver Neoplasms Antibodies  >3 publications with Perp and Liver Neoplasms
Organs/Tissues associated with anti-Perp antibody
 Organ/Tissue Name  Pubmed Publications
 Bladder Antibodies  >13 publications with Perp and Bladder
 Skin Antibodies  >12 publications with Perp and Skin
 Muscle Antibodies  >11 publications with Perp and Muscle
 Lung Antibodies  >8 publications with Perp and Lung
 Eye Antibodies  >7 publications with Perp and Eye
 Intestine Antibodies  >7 publications with Perp and Intestine
 Heart Antibodies  >7 publications with Perp and Heart
 Liver Antibodies  >7 publications with Perp and Liver
 Prostate Antibodies  >5 publications with Perp and Prostate
 Embryonic Tissue Antibodies  >4 publications with Perp and Embryonic Tissue
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