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anti-PFKFB3 antibody :: Rabbit anti-Human PFKFB3 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS416646
Unit / Price
0.1 mg  /  $230 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

PFKFB3, Polyclonal Antibody

 Also Known As   

Anti-PFKFB3 Antibody

 Product Gene Name   

anti-PFKFB3 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    605319
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    Affinity purified
 Form/Format    Liquid
 Concentration    100ug/100ul (lot specific)
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 Storage Buffer    PBS, pH 7.4 with 0.02% Sodium Azide
 Antibody Type    Primary antibody
 Immunogen    Raised against a recombinate human PFKFB3 protein 55-307aa (BC040482).
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 Preparation and Storage    This product is stable for several weeks at 4 degree C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
 Other Notes    Small volumes of anti-PFKFB3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-PFKFB3 antibody

   Rabbit Polyclonal Antibody
 Applications Tested/Suitable for anti-PFKFB3 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-PFKFB3 antibody    ELISA titer: 1:20,000-1:80,000
Western blot analysis: 1:1,000-1:2,000
Immunohistochemistry: 1:100-1:500
Optimal dilutions/concentrations should be determined by the end user
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 Western Blot (WB) of anti-PFKFB3 antibody    anti-PFKFB3 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) #2 of anti-PFKFB3 antibody    anti-PFKFB3 antibody Immunohistochemistry (IHC) #2 (IHC) image
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NCBI/Uniprot data below describe general gene information for PFKFB3. It may not necessarily be applicable to this product.
 NCBI GI #    26251768
 NCBI GeneID    5209
 NCBI Accession #    BC040482 [Other Products]
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 UniProt Secondary Accession #    O43622; O75902; Q5VX15; Q5VX18; Q5VX19; B7Z955 [Other Products]
 UniProt Related Accession #    Q16875 [Other Products]
 Molecular Weight    60,602 Da
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 NCBI Official Full Name    Homo sapiens 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3, mRNA
 NCBI Official Synonym Full Names    6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
 NCBI Official Symbol    PFKFB3 [Similar Products]
 NCBI Official Synonym Symbols   
PFK2; IPFK2
[Similar Products]
 NCBI Protein Information    6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3; 6-phosphofructo-2-kinase/ fructose-2,6-bisphosphatase; 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase; 6PF-2-K/Fru-2,6-P2ase 3; 6PF-2-K/Fru-2,6-P2ase brain/placenta-type isozyme; PFK/FBPase 3; fructose-6-phosphate,2-kinase/fructose-2, 6-bisphosphatase; iPFK-2; inducible 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase; renal carcinoma antigen NY-REN-56
 UniProt Protein Name    6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3
 UniProt Synonym Protein Names   
6PF-2-K/Fru-2,6-P2ase brain/placenta-type isozyme; Renal carcinoma antigen NY-REN-56; iPFK-2Including the following 2 domains:6-phosphofructo-2-kinase (EC:2.7.1.105)Fructose-2,6-bisphosphatase (EC:3.1.3.46)
 Protein Family    6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase
 UniProt Gene Name    PFKFB3 [Similar Products]
 UniProt Entry Name    F263_HUMAN
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 UniProt Comments for PFKFB3    PFKFB3: Synthesis and degradation of fructose 2,6-bisphosphate. Ubiquitous. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.1.3.46; Carbohydrate Metabolism - fructose and mannose; Kinase, other; Phosphatase (non-protein); EC 2.7.1.105; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 10p15.1

Cellular Component: nucleoplasm; cytosol

Molecular Function: fructose-2,6-bisphosphate 2-phosphatase activity; 6-phosphofructo-2-kinase activity; ATP binding

Biological Process: glycolysis; dephosphorylation; carbohydrate metabolic process; carbohydrate phosphorylation; glucose metabolic process; pathogenesis; brain development; fructose 2,6-bisphosphate metabolic process; fructose metabolic process
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Product References and Citations for anti-PFKFB3 antibody

   Tudzarova,S., Colombo,S.L., Stoeber,K., et al. Two ubiquitin ligases, APC/C-Cdh1 and SKP1-CUL1-F (SCF)-beta-TrCP, sequentially regulate glycolysis during the cell cycle. Proc. Natl. Acad. Sci. U.S.A. 108 (13), 5278-5283 (2011)
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 Research Articles on PFKFB3    1. Shear stress-mediated repression of endothelial cell metabolism via KLF2 and PFKFB3 controls endothelial cell phenotype.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-PFKFB3 antibodyPathways associated with anti-PFKFB3 antibody
 Reference Product  PubMed Publications
 HIF1A antibody  >13 publications with PFKFB3 and HIF1A
 PFKP antibody  >1 publications with PFKFB3 and PFKP
 HK2 antibody  >1 publications with PFKFB3 and HK2
 Products by Pathway  Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Fructose And Mannose Metabolism Pathway antibodies  Fructose And Mannose Metabolism Pathway Diagram
 Fructose And Mannose Metabolism Pathway antibodies  Fructose And Mannose Metabolism Pathway Diagram
 Glucose Metabolism Pathway antibodies  Glucose Metabolism Pathway Diagram
 Glycogen Storage Diseases Pathway antibodies  Glycogen Storage Diseases Pathway Diagram
 Glycolysis Pathway antibodies  Glycolysis Pathway Diagram
 HIF-1 Signaling Pathway antibodies  HIF-1 Signaling Pathway Diagram
Diseases associated with anti-PFKFB3 antibodyOrgans/Tissues associated with anti-PFKFB3 antibody
 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >8 publications with PFKFB3 and Breast Neoplasms
 Inflammation Antibodies  >7 publications with PFKFB3 and Inflammation
 Skin Diseases Antibodies  >7 publications with PFKFB3 and Skin Diseases
 Disease Models, Animal Antibodies  >5 publications with PFKFB3 and Disease Models, Animal
 Obesity Antibodies  >5 publications with PFKFB3 and Obesity
 Fatty Liver Antibodies  >4 publications with PFKFB3 and Fatty Liver
 Liver Diseases Antibodies  >3 publications with PFKFB3 and Liver Diseases
 Necrosis Antibodies  >3 publications with PFKFB3 and Necrosis
 Neoplasms, Experimental Antibodies  >3 publications with PFKFB3 and Neoplasms, Experimental
 Brain Diseases Antibodies  >3 publications with PFKFB3 and Brain Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >16 publications with PFKFB3 and Blood
 Liver Antibodies  >14 publications with PFKFB3 and Liver
 Brain Antibodies  >14 publications with PFKFB3 and Brain
 Muscle Antibodies  >11 publications with PFKFB3 and Muscle
 Vascular Antibodies  >10 publications with PFKFB3 and Vascular
 Lung Antibodies  >7 publications with PFKFB3 and Lung
 Testis Antibodies  >7 publications with PFKFB3 and Testis
 Adipose Tissue Antibodies  >6 publications with PFKFB3 and Adipose Tissue
 Kidney Antibodies  >5 publications with PFKFB3 and Kidney
 Connective Tissue Antibodies  >5 publications with PFKFB3 and Connective Tissue
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