NP_004869.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
prostaglandin E synthase
NCBI Official Synonym Full Names
prostaglandin E synthase
NCBI Official Synonym Symbols
PGES; MPGES; PIG12; PP102; PP1294; MGST-IV; MGST1L1; TP53I12; mPGES-1; MGST1-L1 [Similar Products]
NCBI Protein Information
prostaglandin E synthase
UniProt Protein Name
Prostaglandin E synthase
UniProt Synonym Protein Names
Microsomal glutathione S-transferase 1-like 1; MGST1-L1; Microsomal prostaglandin E synthase 1; MPGES-1; p53-induced gene 12 protein
UniProt Synonym Gene Names
UniProt Entry Name
PTGES_HUMAN
NCBI Summary for PGE
The protein encoded by this gene is a glutathione-dependent prostaglandin E synthase. The expression of this gene has been shown to be induced by proinflammatory cytokine interleukin 1 beta (IL1B). Its expression can also be induced by tumor suppressor protein TP53, and may be involved in TP53 induced apoptosis. Knockout studies in mice suggest that this gene may contribute to the pathogenesis of collagen-induced arthritis and mediate acute pain during inflammatory responses. [provided by RefSeq, Jul 2008]
UniProt Comments for PGE
PTGES: Catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). Belongs to the MAPEG family.
Protein type: EC 5.3.99.3; Nuclear envelope; Isomerase; Membrane protein, multi-pass; Membrane protein, integral; Lipid Metabolism - arachidonic acid
Chromosomal Location of Human Ortholog: 9q34.3
Cellular Component: endoplasmic reticulum membrane; membrane; nuclear envelope lumen; perinuclear region of cytoplasm; integral to membrane
Molecular Function: glutathione binding; prostaglandin-E synthase activity
Biological Process: chronic inflammatory response; response to retinoic acid; cyclooxygenase pathway; response to lipopolysaccharide; prostaglandin biosynthetic process; signal transduction; response to organic cyclic substance; prostaglandin metabolic process; negative regulation of cell proliferation; response to cytokine stimulus; arachidonic acid metabolic process; response to calcium ion; acute inflammatory response
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Products associated with anti-PGE antibody
Pathways associated with anti-PGE antibody
Diseases associated with anti-PGE antibody
Organs/Tissues associated with anti-PGE antibody
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