NP_542158.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
72,010 Da
NCBI Official Full Name
prostaglandin G/H synthase 1 isoform 2
NCBI Official Synonym Full Names
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
NCBI Official Synonym Symbols
COX1; COX3; PHS1; PCOX1; PES-1; PGHS1; PTGHS; PGG/HS; PGHS-1 [Similar Products]
NCBI Protein Information
prostaglandin G/H synthase 1; PGH synthase 1; cyclooxygenase-1; prostaglandin H2 synthase 1
UniProt Protein Name
Prostaglandin G/H synthase 1
UniProt Synonym Protein Names
Cyclooxygenase-1; COX-1; Prostaglandin H2 synthase 1; PGH synthase 1; PGHS-1; PHS 1; Prostaglandin-endoperoxide synthase 1
UniProt Synonym Gene Names
UniProt Entry Name
PGH1_HUMAN
NCBI Summary for PGHS-1
This is one of two genes encoding similar enzymes that catalyze the conversion of arachinodate to prostaglandin. The encoded protein regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. Based on its ability to function as both a cyclooxygenase and as a peroxidase, the encoded protein has been identified as a moonlighting protein. The protein may promote cell proliferation during tumor progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
UniProt Comments for PGHS-1
COX-1: May play an important role in regulating or promoting cell proliferation in some normal and neoplastically transformed cells. Homodimer. Belongs to the prostaglandin G/H synthase family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Oxidoreductase; EC 1.14.99.1; Lipid Metabolism - arachidonic acid
Chromosomal Location of Human Ortholog: 9q32-q33.3
Cellular Component: endoplasmic reticulum membrane; photoreceptor outer segment; intracellular membrane-bound organelle; cytoplasm; nucleus
Molecular Function: prostaglandin-endoperoxide synthase activity; peroxidase activity; dioxygenase activity; metal ion binding; heme binding
Biological Process: xenobiotic metabolic process; regulation of blood pressure; cyclooxygenase pathway; arachidonic acid metabolic process; lipid metabolic process; response to oxidative stress; prostaglandin biosynthetic process; inflammatory response; regulation of cell proliferation
Product References and Citations for anti-PGHS-1 antibody
Otto, Jim, Smith, William, J. Biol. Chem. 269: 19868 (Aug. 1994)
Research Articles on PGHS-1
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Products associated with anti-PGHS-1 antibody
Pathways associated with anti-PGHS-1 antibody
Diseases associated with anti-PGHS-1 antibody
Organs/Tissues associated with anti-PGHS-1 antibody
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