BC069741
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
37,611 Da
NCBI Official Full Name
Homo sapiens peptidoglycan recognition protein 3, mRNA
NCBI Official Synonym Full Names
peptidoglycan recognition protein 3
NCBI Official Synonym Symbols
PGRPIA; PGRP-Ialpha; PGLYRPIalpha [Similar Products]
NCBI Protein Information
peptidoglycan recognition protein 3; peptidoglycan recognition protein I alpha; peptidoglycan recognition protein intermediate alpha
UniProt Protein Name
Peptidoglycan recognition protein 3
UniProt Synonym Protein Names
Peptidoglycan recognition protein I-alpha; PGLYRPIalpha; PGRP-I-alpha; Peptidoglycan recognition protein intermediate alpha
UniProt Entry Name
PGRP3_HUMAN
NCBI Summary for PGLYRP3
This gene encodes a peptidoglycan recognition protein, which belongs to the N-acetylmuramoyl-L-alanine amidase 2 family. These proteins are part of the innate immune system and recognize peptidoglycan, a ubiquitous component of bacterial cell walls. This antimicrobial protein binds to murein peptidoglycans of Gram-positive bacteria. [provided by RefSeq, Oct 2014]
UniProt Comments for PGLYRP3
PGLYRP3: Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Binds also to Gram- negative bacteria, and has bacteriostatic activity towards Gram- negative bacteria. Plays a role in innate immunity. Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 1q21
Cellular Component: membrane; extracellular region; intracellular
Molecular Function: peptidoglycan receptor activity; peptidoglycan binding; zinc ion binding; N-acetylmuramoyl-L-alanine amidase activity
Biological Process: defense response to Gram-positive bacterium; negative regulation of natural killer cell differentiation during immune response; detection of bacterium; negative regulation of interferon-gamma production; innate immune response; pattern recognition receptor signaling pathway; peptidoglycan catabolic process
Product References and Citations for anti-PGLYRP3 antibody
(1) Davila,S., Froeling,F.E., Tan,A., et al. New genetic associations detected in a host response study to hepatitis B vaccine. Genes Immun. 11 (3), 232-238 (2010).
Research Articles on PGLYRP3
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Diseases associated with anti-PGLYRP3 antibody
Organs/Tissues associated with anti-PGLYRP3 antibody
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