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anti-ANP32E antibody :: Rabbit PHAP III Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS151145
Unit / Price
0.02 mg  /  $140 +1 FREE 8GB USB
0.1 mg  /  $355 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

PHAP III (ANP32E), Polyclonal Antibody

 Also Known As   

PHAP III Antibody

 Product Synonym Names    PHAP III; LANPL; LANP-L; Acidic leucine-rich nuclear phosphoprotein 32 family member E; LANP-like protein; acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
 Product Gene Name   

anti-ANP32E antibody

[Similar Products]
 Antibody/Peptide Pairs    PHAP III peptide (MBS152716) is used for blocking the activity of PHAP III antibody (MBS151145)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    609611
 3D Structure    ModBase 3D Structure for Q9BTT0
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Specificity    PHAP III has no cross-reaction to PHAP I and PHAP I2a.
 Purity/Purification    PHAP III Antibody is affinity chromatography purified via peptide column.
 Form/Format    Liquid
 Concentration    1 mg/mL (lot specific)
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 Conjugate    Unconjugated
 Immunogen    PHAP III antibody was raised with a synthetic peptide corresponding to amino acids close to carboxy terminus of human PHAP III.
 Buffer    PHAP III Antibody is supplied in PBS containing 0.02% sodium azide.
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 Preparation and Storage    PHAP III antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
 Other Notes    Small volumes of anti-ANP32E antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-ANP32E antibody

   PHAP III Antibody: Apoptosis is related to many diseases and development. Caspase-9 plays a central role in cell death induced by a variety of apoptosis activators. Cytochrome c, after released from mitochondria, binds to Apaf-1, which forms an apoptosome that in turn binds to and activate procaspase-9. Activated caspase-9 cleaves and activates the effector caspases (caspase-3, -6 and -7), which are responsible for the proteolytic cleavage of many key proteins in apoptosis. The tumor suppressor putative HLA-DR-associated proteins (PHAPs) were recently identified as important regulators of mitochondrion apoptosis. PHAP appears to facilitate apoptosome-medicated caspase-9 activation and to stimulate the mitochondrial apoptotic pathway. PHAP was also shown to oppose both Ras- and Myc-medicated cell transformation.
 Applications Tested/Suitable for anti-ANP32E antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

 Application Notes for anti-ANP32E antibody    PHAP III antibody can be used for detection of PHAP III by Western blot at 1 mug/mL. A band at approximately 35 kDa can be detected. Antibody can also be used for immunohistochemistry starting at 2 mug/mL. For immunofluorescence start at 10 mug/mL.
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 Western Blot (WB) of anti-ANP32E antibody    Western blot analysis of PHAP III expression in human A549 (A) and HepG2 (B) cells, and rat testis (C) with PHAP antibody III at 1 μg/mL.
anti-ANP32E antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-ANP32E antibody    Immunohistochemistry of PHAP III in human small intestine tissue with PHAP III antibody at 2 μg/mL.
anti-ANP32E antibody Immunohistochemistry (IHC) (IHC) image
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 Immunofluorescence (IF) of anti-ANP32E antibody    Immunofluorescence of PHAP III in Human Small Intestine cells with PHAP III antibody at 10 μg/mL.
anti-ANP32E antibody Immunofluorescence (IF) image
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NCBI/Uniprot data below describe general gene information for ANP32E. It may not necessarily be applicable to this product.
 NCBI GI #    13569879
 NCBI GeneID    81611
 NCBI Accession #    NP_112182 [Other Products]
 NCBI GenBank Nucleotide #    NM_030920.4 [Other Products]
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 UniProt Primary Accession #    Q9BTT0 [Other Products]
 UniProt Secondary Accession #    Q5TB18; Q5TB20; Q8N1S4; Q8WWW9; B4E0I6; E9PEA6 [Other Products]
 UniProt Related Accession #    Q9BTT0 [Other Products]
 Molecular Weight    35 kDa
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 NCBI Official Full Name    acidic leucine-rich nuclear phosphoprotein 32 family member E isoform 1
 NCBI Official Synonym Full Names    acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
 NCBI Official Symbol    ANP32E [Similar Products]
 NCBI Official Synonym Symbols   
LANPL; LANP-L
[Similar Products]
 NCBI Protein Information    acidic leucine-rich nuclear phosphoprotein 32 family member E; LANP-like protein; leucine-rich acidic nuclear protein like
 UniProt Protein Name    Acidic leucine-rich nuclear phosphoprotein 32 family member E
 UniProt Synonym Protein Names   
LANP-like protein; LANP-L
 Protein Family    Acidic leucine-rich nuclear phosphoprotein 32 family
 UniProt Gene Name    ANP32E [Similar Products]
 UniProt Synonym Gene Names    LANP-L [Similar Products]
 UniProt Entry Name    AN32E_HUMAN
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 UniProt Comments for ANP32E    LANP-L: Inhibits activity of protein phosphatase 2A (PP2A). Does not inhibit protein phosphatase 1. May play a role in cerebellar development and synaptogenesis process by modulating PP2A activity. Belongs to the ANP32 family.

Protein type: Inhibitor; Protein phosphatase, regulatory subunit; Vesicle; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 1q21.2

Cellular Component: cytoplasmic membrane-bound vesicle; nucleus

Molecular Function: phosphatase inhibitor activity; histone binding

Biological Process: negative regulation of catalytic activity; histone exchange
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 Research Articles on ANP32E    1. 1.48 A resolution crystal structure of the complex formed between the ANP32E-ZID and the H2A.Z/H2B dimer and biochemical data support an underlying molecular mechanism for H2A.Z/H2B eviction from the nucleosome and its stabilization by ANP32E
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Diseases associated with anti-ANP32E antibodyOrgans/Tissues associated with anti-ANP32E antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >3 publications with ANP32E and Inflammation
 Breast Neoplasms Antibodies  >2 publications with ANP32E and Breast Neoplasms
 Lung Neoplasms Antibodies  >1 publications with ANP32E and Lung Neoplasms
 Death Antibodies  >1 publications with ANP32E and Death
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >6 publications with ANP32E and Brain
 Blood Antibodies  >4 publications with ANP32E and Blood
 Embryonic Tissue Antibodies  >2 publications with ANP32E and Embryonic Tissue
 Muscle Antibodies  >1 publications with ANP32E and Muscle
 Lung Antibodies  >1 publications with ANP32E and Lung
 Spleen Antibodies  >1 publications with ANP32E and Spleen
 Prostate Antibodies  >1 publications with ANP32E and Prostate
 Kidney Antibodies  >1 publications with ANP32E and Kidney
 Liver Antibodies  >1 publications with ANP32E and Liver
 Stomach Antibodies  >1 publications with ANP32E and Stomach
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