AAH75808.1
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
PHD finger protein 5A
NCBI Official Synonym Full Names
PHD finger protein 5A
NCBI Official Synonym Symbols
INI; Rds3; SF3B7; SAP14b; SF3b14b; bK223H9.2 [Similar Products]
NCBI Protein Information
PHD finger-like domain-containing protein 5A; PHD-finger 5a; splicing factor 3b, subunit 7; PHD finger-like domain protein 5A; splicing factor 3B associated 14 kDa protein; splicing factor 3B-associated 14 kDa protein
UniProt Protein Name
PHD finger-like domain-containing protein 5A
UniProt Synonym Protein Names
Splicing factor 3B-associated 14 kDa protein; SF3b14b
UniProt Synonym Gene Names
UniProt Entry Name
PHF5A_HUMAN
NCBI Summary for PHF5A
This gene encodes a subunit of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence-independent manner and may anchor the U2 snRNP to the pre-mRNA. The protein encoded by this gene contains a PHD-finger-like domain that is flanked by highly basic N- and C-termini. This protein belongs to the PHD-finger superfamily and may act as a chromatin-associated protein. This gene has several pseudogenes on different chromosomes. [provided by RefSeq, Jul 2008]
UniProt Comments for PHF5A
PHF5A: Acts as a transcriptional regulator by binding to the GJA1/Cx43 promoter and enhancing its up-regulation by ESR1/ER- alpha. Also involved in pre-mRNA splicing. Belongs to the PHF5 family.
Protein type: RNA-binding; RNA splicing
Chromosomal Location of Human Ortholog: 22q13.2
Cellular Component: nucleoplasm; nuclear matrix; snRNP U2; nuclear speck; U12-dependent spliceosome
Molecular Function: DNA binding; transcription factor activity
Biological Process: nuclear mRNA splicing, via spliceosome; transcription, DNA-dependent; RNA splicing; positive regulation of transcription, DNA-dependent; gene expression
Research Articles on PHF5A
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Pathways associated with anti-PHF5A antibody
Diseases associated with anti-PHF5A antibody
Organs/Tissues associated with anti-PHF5A antibody
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