NP_005160.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
29,653 Da
NCBI Official Full Name
paired mesoderm homeobox protein 2A
NCBI Official Synonym Full Names
paired like homeobox 2a
NCBI Official Synonym Symbols
ARIX; FEOM2; NCAM2; PMX2A; CFEOM2 [Similar Products]
NCBI Protein Information
paired mesoderm homeobox protein 2A
UniProt Protein Name
Paired mesoderm homeobox protein 2A
UniProt Synonym Protein Names
ARIX1 homeodomain protein; Aristaless homeobox protein homolog; Paired-like homeobox 2A
UniProt Synonym Gene Names
NCBI Summary for PHOX2A
The protein encoded by this gene contains a paired-like homeodomain most similar to that of the Drosophila aristaless gene product. The encoded protein plays a central role in development of the autonomic nervous system. It regulates the expression of tyrosine hydroxylase and dopamine beta-hydroxylase, two catecholaminergic biosynthetic enzymes essential for the differentiation and maintenance of the noradrenergic neurotransmitter phenotype. The encoded protein has also been shown to regulate transcription of the alpha3 nicotinic acetylcholine receptor gene. Mutations in this gene have been associated with autosomal recessive congenital fibrosis of the extraocular muscles. [provided by RefSeq, Jul 2008]
UniProt Comments for PHOX2A
May be involved in regulating the specificity of expression of the catecholamine biosynthetic genes. Acts as a transcription activator/factor. Could maintain the noradrenergic phenotype.
Research Articles on PHOX2A
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Products associated with anti-PHOX2A antibody
Pathways associated with anti-PHOX2A antibody
Diseases associated with anti-PHOX2A antibody
Organs/Tissues associated with anti-PHOX2A antibody
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