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anti-PIK3CD antibody :: Rabbit PI-3 KINASE p110 SUBUNIT DELTA Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS224138 anti-PIK3CD antibody
Unit / Price
0.1 mg  /  $465 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

PI-3 KINASE p110 SUBUNIT DELTA (PIK3CD), Polyclonal Antibody

 Also Known As   

RABBIT ANTI HUMAN PI-3 KINASE p110 SUBUNIT DELTA (C-TERMINAL)

 Product Gene Name   

anti-PIK3CD antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    602839
 3D Structure    ModBase 3D Structure for O00329
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
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 Form/Format    Purified
Purified IgG - liquid
 Concentration    IgG concentration 1.0mg/ml (lot specific)
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 Perservative Stabilisers    0.09% Sodium Azide (NaN3)
0.1% Bovine Serum Albumin
 Buffer Solution    Phosphate buffered saline
 Antiserum Preparation    Antiserum to p110 delta (CT) was raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG was prepared by affinity chromatography.
 Target Species    Human
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 Preparation and Storage    Store at -20 degree C only. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
 Other Notes    Small volumes of anti-PIK3CD antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-PIK3CD antibody

   Rabbit anti Human PI-3 kinase subunit Delta recognizes an epitope within the C-terminal (CT) region of human PI3-kinase p110 subunit delta (Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta), a member of the PI3/PI4-kinase family of lipid kinases, implicated in the regulation of signal transduction during cell growth. PI3-kinase is a heterodimer consisting of a p85 regulatory subunit and a p110 catalytic subunit, which itself is divided into isoforms p110alpha, p110beta, p110delta and p110gamma. Studies have shown that p110delta is predominantly restricted to leucocytes, exhibits a broad phosphoinositide lipid substrate specificity, and binds to Ras-GTP and p85. Rabbit anti Human PI-3 kinase subunit Delta is reported as suitable for use in immunocytochemistry.
 Applications Tested/Suitable for anti-PIK3CD antibody   

ELISA (EIA), Western Blot (WB)

 Application Notes for anti-PIK3CD antibody    ELISA: This product is suitable for use in indirect ELISA applications.
ELISA: Maximum Dilution: 1/75000
Western Blotting: Maximum Dilution: 1/3000
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NCBI/Uniprot data below describe general gene information for PIK3CD. It may not necessarily be applicable to this product.
 NCBI GI #    156564405
 NCBI GeneID    5293
 NCBI Accession #    NP_005017.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_005026.3 [Other Products]
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 UniProt Primary Accession #    O00329 [Other Products]
 UniProt Secondary Accession #    O15445; Q5SR49; A6NCG0; G1FFP1 [Other Products]
 UniProt Related Accession #    O00329 [Other Products]
 Molecular Weight    33,107 Da [Similar Products]
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 NCBI Official Full Name    phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
 NCBI Official Synonym Full Names    phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
 NCBI Official Symbol    PIK3CD [Similar Products]
 NCBI Official Synonym Symbols   
APDS; PI3K; IMD14; p110D; P110DELTA
[Similar Products]
 NCBI Protein Information    phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform; PI3-kinase p110 subunit delta; PI3Kdelta; phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform; phosphoinositide-3-kinase C; phosphoinositide-3-kinase, catalytic, delta polypeptide variant p37delta; ptdIns-3-kinase subunit p110-delta
 UniProt Protein Name    Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
 UniProt Synonym Protein Names   
Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta; PtdIns-3-kinase subunit p110-delta; p110delta
 Protein Family    Phosphatidylinositol 4,5-bisphosphate 3-kinase
 UniProt Gene Name    PIK3CD [Similar Products]
 UniProt Synonym Gene Names    PI3-kinase subunit delta; PI3K-delta; PI3Kdelta; PtdIns-3-kinase subunit delta; PtdIns-3-kinase subunit p110-delta; p110delta [Similar Products]
 UniProt Entry Name    PK3CD_HUMAN
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 NCBI Summary for PIK3CD    Phosphoinositide 3-kinases (PI3Ks) phosphorylate inositol lipids and are involved in the immune response. The protein encoded by this gene is a class I PI3K found primarily in leukocytes. Like other class I PI3Ks (p110-alpha p110-beta, and p110-gamma), the encoded protein binds p85 adapter proteins and GTP-bound RAS. However, unlike the other class I PI3Ks, this protein phosphorylates itself, not p85 protein.[provided by RefSeq, Jul 2010]
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 UniProt Comments for PIK3CD    PIK3CD: Phosphoinositide-3-kinase (PI3K) that phosphorylates PftdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Mediates immune responses. Plays a role in B-cell development, proliferation, migration, and function. Required for B-cell receptor (BCR) signaling. Mediates B-cell proliferation response to anti-IgM, anti-CD40 and IL4 stimulation. Promotes cytokine production in response to TLR4 and TLR9. Required for antibody class switch mediated by TLR9. Involved in the antigen presentation function of B-cells. Involved in B-cell chemotaxis in response to CXCL13 and sphingosine 1-phosphate (S1P). Required for proliferation, signaling and cytokine production of naive, effector and memory T-cells. Required for T-cell receptor (TCR) signaling. Mediates TCR signaling events at the immune synapse. Activation by TCR leads to antigen-dependent memory T-cell migration and retention to antigenic tissues. Together with PIK3CG participates in T-cell development. Contributes to T-helper cell expansion and differentiation. Required for T-cell migration mediated by homing receptors SELL/CD62L, CCR7 and S1PR1 and antigen dependent recruitment of T-cells. Together with PIK3CG is involved in natural killer (NK) cell development and migration towards the sites of inflammation. Participates in NK cell receptor activation. Have a role in NK cell maturation and cytokine production. Together with PIK3CG is involved in neutrophil chemotaxis and extravasation. Together with PIK3CG participates in neutrophil respiratory burst. Have important roles in mast-cell development and mast cell mediated allergic response. Involved in stem cell factor (SCF)-mediated proliferation, adhesion and migration. Required for allergen-IgE-induced degranulation and cytokine release. The lipid kinase activity is required for its biological function. Isoform 2 may be involved in stabilizing total RAS levels, resulting in increased ERK phosphorylation and increased PI3K activity. Belongs to the PI3/PI4-kinase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.153; Motility/polarity/chemotaxis; Kinase, lipid

Chromosomal Location of Human Ortholog: 1p36.2

Cellular Component: mast cell granule; plasma membrane; phosphoinositide 3-kinase complex; cytosol

Molecular Function: protein binding; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; 1-phosphatidylinositol-3-kinase activity; phosphoinositide 3-kinase activity; phosphatidylinositol-4-phosphate 3-kinase activity; ATP binding

Biological Process: respiratory burst during defense response; phosphoinositide 3-kinase cascade; T cell activation; nerve growth factor receptor signaling pathway; natural killer cell activation; signal transduction; T cell receptor signaling pathway; protein amino acid phosphorylation; B cell receptor signaling pathway; B cell homeostasis; phosphoinositide phosphorylation; natural killer cell differentiation; phospholipid metabolic process; inflammatory response; T cell differentiation; epidermal growth factor receptor signaling pathway; neutrophil chemotaxis; adaptive immune response; phosphoinositide-mediated signaling; fibroblast growth factor receptor signaling pathway; B cell activation; mast cell chemotaxis; cytokine production; mast cell degranulation; phosphatidylinositol biosynthetic process; innate immune response

Disease: Immunodeficiency 14
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 Research Articles on PIK3CD    1. The p110delta PI3K-selective compound CAL-101 (Idelalisib) did not inhibit markers of PI3K activity in cancer or stromal cells.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-PIK3CD antibodyPathways associated with anti-PIK3CD antibody
 Reference Product  PubMed Publications
 PTEN antibody  >10 publications with PIK3CD and PTEN
 PIK3R1 antibody  >9 publications with PIK3CD and PIK3R1
 AKT1 antibody  >5 publications with PIK3CD and AKT1
 ERBB4 antibody  >3 publications with PIK3CD and ERBB4
 SYK antibody  >3 publications with PIK3CD and SYK
 SRC antibody  >2 publications with PIK3CD and SRC
 IRS1 antibody  >1 publications with PIK3CD and IRS1
 Products by Pathway  Pathway Diagram
 3-phosphoinositide Biosynthesis Pathway antibodies  3-phosphoinositide Biosynthesis Pathway Diagram
 3-phosphoinositide Biosynthesis Pathway antibodies  3-phosphoinositide Biosynthesis Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 Acute Myeloid Leukemia Pathway antibodies  Acute Myeloid Leukemia Pathway Diagram
 Acute Myeloid Leukemia Pathway antibodies  Acute Myeloid Leukemia Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Adrenergic Signaling In Cardiomyocytes Pathway antibodies  Adrenergic Signaling In Cardiomyocytes Pathway Diagram
 Adrenergic Signaling In Cardiomyocytes Pathway antibodies  Adrenergic Signaling In Cardiomyocytes Pathway Diagram
Diseases associated with anti-PIK3CD antibodyOrgans/Tissues associated with anti-PIK3CD antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >32 publications with PIK3CD and Inflammation
 Necrosis Antibodies  >15 publications with PIK3CD and Necrosis
 Lymphoma Antibodies  >12 publications with PIK3CD and Lymphoma
 Nervous System Diseases Antibodies  >6 publications with PIK3CD and Nervous System Diseases
 Neoplasms, Experimental Antibodies  >5 publications with PIK3CD and Neoplasms, Experimental
 Breast Neoplasms Antibodies  >4 publications with PIK3CD and Breast Neoplasms
 Neoplasm Invasiveness Antibodies  >4 publications with PIK3CD and Neoplasm Invasiveness
 Skin Diseases Antibodies  >3 publications with PIK3CD and Skin Diseases
 Liver Neoplasms Antibodies  >3 publications with PIK3CD and Liver Neoplasms
 Atherosclerosis Antibodies  >3 publications with PIK3CD and Atherosclerosis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >68 publications with PIK3CD and Blood
 Lung Antibodies  >10 publications with PIK3CD and Lung
 Bone Antibodies  >10 publications with PIK3CD and Bone
 Liver Antibodies  >8 publications with PIK3CD and Liver
 Bone Marrow Antibodies  >8 publications with PIK3CD and Bone Marrow
 Vascular Antibodies  >8 publications with PIK3CD and Vascular
 Lymph Node Antibodies  >7 publications with PIK3CD and Lymph Node
 Spleen Antibodies  >6 publications with PIK3CD and Spleen
 Brain Antibodies  >6 publications with PIK3CD and Brain
 Lymph Antibodies  >6 publications with PIK3CD and Lymph
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