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anti-PIAS2 antibody :: Rabbit anti-Human PIAS2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS1497201 anti-PIAS2 antibody
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

PIAS2, Polyclonal Antibody

 Also Known As   

PIAS2 Antibody, HRP conjugated

 Product Synonym Names    E3 SUMO-protein ligase PIAS2; Androgen receptor-interacting protein 3; ARIP3; DAB2-interacting protein; DIP; Msx-interacting zinc finger protein; PIAS-NY protein; Protein inhibitor of activated STAT x; Protein inhibitor of activated STAT2; PIAS2; PIASX
 Product Gene Name   

anti-PIAS2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    603567
 3D Structure    ModBase 3D Structure for O75928
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    Caprylic Acid Ammonium Sulfate Precipitation Purified
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 Storage Buffer    Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
 Conjugate    HRP
 Immunogen    Recombinant human E3 SUMO-protein ligase PIAS2 protrin(1-572AA)
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-18245 / sc-30879 / sc-30878
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-PIAS2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-PIAS2 antibody

   Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulator in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. The effects of this transcriptional coregulation, transactivation or silencing may vary depending upon the biological context and the PIAS2 isoform studied. However, it seems to be mostly involved in gene silencing. Binds to sumoylated ELK1 and enhances its transcriptional activity by preventing recruitment of HDAC2 by ELK1, thus reversing SUMO-mediated repression of ELK1 transactivation activity. Isoform PIAS2-beta, but not isoform PIAS2-alpha, promotes MDM2 sumoylation. Isoform PIAS2-alpha promotes PARK7 sumoylation. Isoform PIAS2-beta promotes NCOA2 sumoylation more efficiently than isoform PIAS2-alpha. Isoform PIAS2-alpha sumoylates PML at'Lys-65' and 'Lys-160'.
 Applications Tested/Suitable for anti-PIAS2 antibody   

ELISA (EIA)

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NCBI/Uniprot data below describe general gene information for PIAS2. It may not necessarily be applicable to this product.
 NCBI GI #    56699458
 NCBI GeneID    9063
 NCBI Accession #    NP_004662.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_004671.3 [Other Products]
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 UniProt Primary Accession #    O75928 [Other Products]
 UniProt Secondary Accession #    O75927; Q96BT5; Q96KE3 [Other Products]
 UniProt Related Accession #    O75928 [Other Products]
 Molecular Weight    45,057 Da
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 NCBI Official Full Name    E3 SUMO-protein ligase PIAS2 isoform beta
 NCBI Official Synonym Full Names    protein inhibitor of activated STAT 2
 NCBI Official Symbol    PIAS2 [Similar Products]
 NCBI Official Synonym Symbols   
DIP; MIZ; MIZ1; SIZ2; ARIP3; PIASX; ZMIZ4; PIASX-BETA; PIASX-ALPHA
[Similar Products]
 NCBI Protein Information    E3 SUMO-protein ligase PIAS2
 UniProt Protein Name    E3 SUMO-protein ligase PIAS2
 UniProt Synonym Protein Names   
Androgen receptor-interacting protein 3; ARIP3; DAB2-interacting protein; DIP; Msx-interacting zinc finger protein; Miz1; PIAS-NY protein; Protein inhibitor of activated STAT x; Protein inhibitor of activated STAT2
 Protein Family    E3 SUMO-protein ligase
 UniProt Gene Name    PIAS2 [Similar Products]
 UniProt Synonym Gene Names    PIASX; ARIP3; DIP; Miz1 [Similar Products]
 UniProt Entry Name    PIAS2_HUMAN
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 NCBI Summary for PIAS2    This gene encodes a member of the protein inhibitor of activated STAT (PIAS) family. PIAS proteins function as SUMO E3 ligases and play important roles in many cellular processes by mediating the sumoylation of target proteins. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Isoforms of the encoded protein enhance the sumoylation of specific target proteins including the p53 tumor suppressor protein, c-Jun, and the androgen receptor. A pseudogene of this gene is located on the short arm of chromosome 4. The symbol MIZ1 has also been associated with ZBTB17 which is a different gene located on chromosome 1. [provided by RefSeq, Aug 2011]
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 UniProt Comments for PIAS2    Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulator in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. The effects of this transcriptional coregulation, transactivation or silencing may vary depending upon the biological context and the PIAS2 isoform studied. However, it seems to be mostly involved in gene silencing. Binds to sumoylated ELK1 and enhances its transcriptional activity by preventing recruitment of HDAC2 by ELK1, thus reversing SUMO-mediated repression of ELK1 transactivation activity. Isoform PIAS2-beta, but not isoform PIAS2-alpha, promotes MDM2 sumoylation. Isoform PIAS2-alpha promotes PARK7 sumoylation. Isoform PIAS2-beta promotes NCOA2 sumoylation more efficiently than isoform PIAS2-alpha. Isoform PIAS2-alpha sumoylates PML at'Lys-65' and 'Lys-160'.
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 Research Articles on PIAS2    1. the expression of SENP8, SAE1, PIAS1, PIAS2 and ZMIZ1 is deregulated in the majority of PTC tissues, likely contributing to the PTC phenotype.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-PIAS2 antibodyPathways associated with anti-PIAS2 antibody
 Reference Product  PubMed Publications
 SUMO1 antibody  >23 publications with PIAS2 and SUMO1
 SUMO2 antibody  >6 publications with PIAS2 and SUMO2
 STAT1 antibody  >4 publications with PIAS2 and STAT1
 MYC antibody  >3 publications with PIAS2 and MYC
 STAT3 antibody  >1 publications with PIAS2 and STAT3
 SMAD4 antibody  >1 publications with PIAS2 and SMAD4
 STAT4 antibody  >1 publications with PIAS2 and STAT4
 Products by Pathway  Pathway Diagram
 Activation Of HOX Genes During Differentiation Pathway antibodies  Activation Of HOX Genes During Differentiation Pathway Diagram
 Activation Of Anterior HOX Genes In Hindbrain Development During Early Embryogenesis Pathway antibodies  Activation Of Anterior HOX Genes In Hindbrain Development During Early Embryogenesis Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 IL12 Signaling Mediated By STAT4 Pathway antibodies  IL12 Signaling Mediated By STAT4 Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Pathways In Cancer antibodies  Pathways In Cancer Diagram
 Post-translational Protein Modification Pathway antibodies  Post-translational Protein Modification Pathway Diagram
 SUMO E3 Ligases SUMOylate Target Proteins Pathway antibodies  SUMO E3 Ligases SUMOylate Target Proteins Pathway Diagram
Diseases associated with anti-PIAS2 antibodyOrgans/Tissues associated with anti-PIAS2 antibody
 Disease Name  Pubmed Publications
 Immune System Diseases Antibodies  >3 publications with PIAS2 and Immune System Diseases
 Immunoproliferative Disorders Antibodies  >2 publications with PIAS2 and Immunoproliferative Disorders
 Brain Diseases Antibodies  >1 publications with PIAS2 and Brain Diseases
 Chromosome Aberrations Antibodies  >1 publications with PIAS2 and Chromosome Aberrations
 Congenital Abnormalities Antibodies  >1 publications with PIAS2 and Congenital Abnormalities
 Fibrosis Antibodies  >1 publications with PIAS2 and Fibrosis
 Nerve Degeneration Antibodies  >1 publications with PIAS2 and Nerve Degeneration
 Inflammation Antibodies  >1 publications with PIAS2 and Inflammation
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >3 publications with PIAS2 and Bone
 Brain Antibodies  >3 publications with PIAS2 and Brain
 Muscle Antibodies  >2 publications with PIAS2 and Muscle
 Thyroid Antibodies  >1 publications with PIAS2 and Thyroid
 Liver Antibodies  >1 publications with PIAS2 and Liver
 Pancreas Antibodies  >1 publications with PIAS2 and Pancreas
 Embryonic Tissue Antibodies  >1 publications with PIAS2 and Embryonic Tissue
 Testis Antibodies  >1 publications with PIAS2 and Testis
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