NP_002633.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
33,583 Da
NCBI Official Full Name
phosphatidylinositol N-acetylglucosaminyltransferase subunit C
NCBI Official Synonym Full Names
phosphatidylinositol glycan anchor biosynthesis class C
NCBI Official Synonym Symbols
NCBI Protein Information
phosphatidylinositol N-acetylglucosaminyltransferase subunit C
UniProt Protein Name
Phosphatidylinositol N-acetylglucosaminyltransferase subunit C
UniProt Synonym Protein Names
Phosphatidylinositol-glycan biosynthesis class C protein; PIG-C
UniProt Synonym Gene Names
UniProt Entry Name
PIGC_HUMAN
NCBI Summary for PIGC
This gene encodes an endoplasmic reticulum associated protein that is involved in glycosylphosphatidylinositol (GPI) lipid anchor biosynthesis. The GPI lipid anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. The encoded protein is one subunit of the GPI N-acetylglucosaminyl (GlcNAc) transferase that transfers GlcNAc to phosphatidylinositol (PI) on the cytoplasmic side of the endoplasmic reticulum. Two alternatively spliced transcripts that encode the same protein have been found for this gene. A pseudogene on chromosome 11 has also been characterized. [provided by RefSeq, Jul 2008]
UniProt Comments for PIGC
PIGC: Part of the complex catalyzing the transfer of N- acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis. Belongs to the PIGC family.
Protein type: Endoplasmic reticulum; Glycan Metabolism - glycosylphosphatidylinositol (GPI)-anchor biosynthesis; Membrane protein, integral; Membrane protein, multi-pass; EC 2.4.1.198; Transferase
Chromosomal Location of Human Ortholog: 1q23-q25
Cellular Component: endoplasmic reticulum membrane; glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex; integral to membrane
Molecular Function: catalytic activity; phosphatidylinositol N-acetylglucosaminyltransferase activity
Biological Process: C-terminal protein lipidation; cellular protein metabolic process; GPI anchor biosynthetic process; post-translational protein modification; preassembly of GPI anchor in ER membrane
Research Articles on PIGC
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Products associated with anti-PIGC antibody
Pathways associated with anti-PIGC antibody
Diseases associated with anti-PIGC antibody
Organs/Tissues associated with anti-PIGC antibody
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