NP_001333683.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
Observed: 57 kDa Predicted: 57 kDa
NCBI Official Full Name
phosphatidylinositol-glycan biosynthesis class W protein
NCBI Official Synonym Full Names
phosphatidylinositol glycan anchor biosynthesis class W
NCBI Official Synonym Symbols
NCBI Protein Information
phosphatidylinositol-glycan biosynthesis class W protein
UniProt Protein Name
Phosphatidylinositol-glycan biosynthesis class W protein
UniProt Synonym Gene Names
NCBI Summary for PIGW
The protein encoded by this gene is an inositol acyltransferase that acylates the inositol ring of phosphatidylinositol. This occurs in the endoplasmic reticulum and is a step in the biosynthesis of glycosylphosphatidylinositol (GPI), which anchors many cell surface proteins to the membrane. Defects in this gene are a cause of the age-dependent epileptic encephalopathy West syndrome as well as a syndrome exhibiting hyperphosphatasia and cognitive disability (HPMRS5). [provided by RefSeq, Jul 2017]
UniProt Comments for PIGW
Required for the transport of GPI-anchored proteins to the plasma membrane (PubMed:24367057). Probable acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI-anchor. Acetylation during GPI-anchor biosynthesis is not essential for the subsequent mannosylation and is usually removed soon after the attachment of GPIs to proteins ().
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Products associated with anti-PIGW antibody
Pathways associated with anti-PIGW antibody
Diseases associated with anti-PIGW antibody
Organs/Tissues associated with anti-PIGW antibody
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