NM_001321378.1
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha isoform 1
NCBI Official Synonym Full Names
phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha
NCBI Official Synonym Symbols
CPK; PI3-K-C2A; PI3K-C2alpha; PI3K-C2-alpha; PI3-K-C2(ALPHA) [Similar Products]
NCBI Protein Information
phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha
UniProt Protein Name
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha
UniProt Synonym Protein Names
Phosphoinositide 3-kinase-C2-alpha
UniProt Synonym Gene Names
UniProt Entry Name
P3C2A_HUMAN
NCBI Summary for PIK3C2A
The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is not sensitive to nanomolar levels of the inhibitor wortmanin. This protein was shown to be able to be activated by insulin and may be involved in integrin-dependent signaling. [provided by RefSeq, Jul 2008]
UniProt Comments for PIK3C2A
PIK3C2A: a protein of the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. Its PI3-kinase is not sensitive to nanomolar levels of the inhibitor wortmannin. Activated by insulin and may be involved in integrin-dependent signaling.
Protein type: Autophagy; Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.154; Kinase, lipid; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 11p15.5-p14
Cellular Component: cytoplasm; cytosol; membrane; phosphoinositide 3-kinase complex; plasma membrane; vesicle
Molecular Function: 1-phosphatidylinositol-3-kinase activity; phosphatidylinositol-4-phosphate 3-kinase activity; phosphoinositide 3-kinase activity
Biological Process: clathrin cage assembly; endocytosis; epidermal growth factor receptor signaling pathway; exocytosis; insulin receptor signaling pathway; phosphatidylinositol biosynthetic process; platelet-derived growth factor receptor signaling pathway; vascular smooth muscle contraction
Research Articles on PIK3C2A
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Products associated with anti-PIK3C2A antibody
Pathways associated with anti-PIK3C2A antibody
Diseases associated with anti-PIK3C2A antibody
Organs/Tissues associated with anti-PIK3C2A antibody
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