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anti-PIK3R6 antibody :: Rabbit PIK3R6 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS820596 anti-PIK3R6 antibody
Unit / Price
0.03 mL  /  $155 +1 FREE 8GB USB
0.1 mL  /  $220 +1 FREE 8GB USB
0.2 mL  /  $295 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

PIK3R6, Polyclonal Antibody

★Popular Item★
 Also Known As   

Anti-PIK3R6 Antibody

 Product Synonym Names    C17orf38; Phosphoinositide 3-kinase regulatory subunit 6; Phosphoinositide 3-kinase gamma adapter protein of 87 kDa; p84 PI3K adapter protein; p84 PIKAP; p87 PI3K adapter protein; p87PIKAP
 Product Gene Name   

anti-PIK3R6 antibody

[Similar Products]
 Antibody/Peptide Pairs    PIK3R6 peptide (MBS822460) is used for blocking the activity of PIK3R6 antibody (MBS820596)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    611462
 3D Structure    ModBase 3D Structure for Q5UE93
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Specificity    Recognizes endogenous levels of PIK3R6 protein.
 Purity/Purification    The antibody was purified by immunogen affinity chromatography.
 Form/Format    Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
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 Immunogen    KLH-conjugated synthetic peptide encompassing a sequence within the center region of human PIK3R6. The exact sequence is proprietary.
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.
 Other Notes    Small volumes of anti-PIK3R6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-PIK3R6 antibody

   Rabbit polyclonal antibody to PIK3R6
 Applications Tested/Suitable for anti-PIK3R6 antibody   

Western Blot (WB)

 Application Notes for anti-PIK3R6 antibody    WB (1/500 - 1/1000)
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 Western Blot (WB) of anti-PIK3R6 antibody    anti-PIK3R6 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for PIK3R6. It may not necessarily be applicable to this product.
 NCBI GI #    58082081
 NCBI GeneID    146850
 NCBI Accession #    NP_001010855.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001010855.3 [Other Products]
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 UniProt Primary Accession #    Q5UE93 [Other Products]
 UniProt Secondary Accession #    Q658R3 [Other Products]
 UniProt Related Accession #    Q5UE93 [Other Products]
 Molecular Weight    84,258 Da
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 NCBI Official Full Name    phosphoinositide 3-kinase regulatory subunit 6 isoform 1
 NCBI Official Synonym Full Names    phosphoinositide-3-kinase, regulatory subunit 6
 NCBI Official Symbol    PIK3R6 [Similar Products]
 NCBI Official Synonym Symbols   
C17orf38; HsT41028; p87PIKAP; p84 PIKAP; p87(PIKAP)
[Similar Products]
 NCBI Protein Information    phosphoinositide 3-kinase regulatory subunit 6; p84 PI3K adapter protein; PI3Kgamma adapter protein of 87 kDa; p87 phosphoinositide 3-kinase gamma (PI3Kg) adapter protein
 UniProt Protein Name    Phosphoinositide 3-kinase regulatory subunit 6
 UniProt Synonym Protein Names   
Phosphoinositide 3-kinase gamma adapter protein of 87 kDa; p84 PI3K adapter protein; p84 PIKAP; p87 PI3K adapter protein; p87PIKAP
 Protein Family    Phosphoinositide 3-kinase regulatory
 UniProt Gene Name    PIK3R6 [Similar Products]
 UniProt Synonym Gene Names    C17orf38; p84 PIKAP; p87PIKAP [Similar Products]
 UniProt Entry Name    PI3R6_HUMAN
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 NCBI Summary for PIK3R6    Phosphoinositide 3-kinase gamma is a lipid kinase that produces the lipid second messenger phosphatidylinositol 3,4,5-trisphosphate. The kinase is composed of a catalytic subunit and one of several regulatory subunits, and is chiefly activated by G protein-coupled receptors. This gene encodes a regulatory subunit, and is distantly related to the phosphoinositide-3-kinase, regulatory subunit 5 gene which is located adjacent to this gene on chromosome 7. The orthologous protein in the mouse binds to both the catalytic subunit and to G(beta/gamma), and mediates activation of the kinase subunit downstream of G protein-coupled receptors. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
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 UniProt Comments for PIK3R6    PIK3R6: Regulatory subunit of the PI3K gamma complex. Acts as an adapter to drive activation of PIK3CG by beta-gamma G protein dimers. The PIK3CG:PIK3R6 heterodimer is much less sensitive to beta-gamma G protein dimers than PIK3CG:PIK3R5 and its membrane recruitment and beta-gamma G protein dimer-dependent activation requires HRAS1 bound to PIK3CG. Recruits of the PI3K gamma complex to a PDE3B:RAPGEF3 signaling complex involved in angiogenesis; signaling seems to involve RRAS.

Chromosomal Location of Human Ortholog: 17p13.1

Cellular Component: membrane; cytosol

Molecular Function: protein binding; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; 1-phosphatidylinositol-3-kinase regulator activity

Biological Process: positive regulation of MAP kinase activity; G-protein coupled receptor protein signaling pathway; platelet activation; positive regulation of angiogenesis; phosphoinositide phosphorylation; phospholipid metabolic process; phosphatidylinositol biosynthetic process; angiogenesis; blood coagulation; regulation of phosphoinositide 3-kinase activity
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 Research Articles on PIK3R6    1. expression and activities of PI3Kgamma are modified differently by p87 and p101 in vitro and in living cells, arguing for specific regulatory roles of the non-catalytic subunits in the differentiation of PI3Kgamma signaling pathways.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-PIK3R6 antibodyPathways associated with anti-PIK3R6 antibody
 Reference Product  PubMed Publications
 PIK3R5 antibody  >1 publications with PIK3R6 and PIK3R5
 Products by Pathway  Pathway Diagram
 3-phosphoinositide Biosynthesis Pathway antibodies  3-phosphoinositide Biosynthesis Pathway Diagram
 3-phosphoinositide Biosynthesis Pathway antibodies  3-phosphoinositide Biosynthesis Pathway Diagram
 G Beta:gamma Signalling Through PI3Kgamma Pathway antibodies  G Beta:gamma Signalling Through PI3Kgamma Pathway Diagram
 G-protein Beta:gamma Signalling Pathway antibodies  G-protein Beta:gamma Signalling Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPVI-mediated Activation Cascade Pathway antibodies  GPVI-mediated Activation Cascade Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 PI Metabolism Pathway antibodies  PI Metabolism Pathway Diagram
Organs/Tissues associated with anti-PIK3R6 antibody
 Organ/Tissue Name  Pubmed Publications
 Bone Marrow Antibodies  >1 publications with PIK3R6 and Bone Marrow
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