Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Antibody rightarrow PITRM1 rightarrow Polyclonal PITRM1  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • RBM8A cDNA Clone
 • Annexin A3 (ANXA3) Antibody
 • ARSA ELISA Kit
 • Paraoxonase 2 (PON2) ELISA Kit
 • SEX HORMONE BINDING GLOBULIN (SHBG) Antibody
 • TRIM5 gamma Antibody
 • QARS Antibody
 • secreted phosphoprotein 1 (SPP1) ELISA Kit
 • Glyoxalase I (GLO1) ELISA Kit
 • p53 Antibody
 • ACTB - Beta Actin Antibody
 • Troponin I Antibody
 • MST4 (RP6-213H19.1) Antibody
 • Phosphotylinosital 3 kinase, PI3K ELISA Kit
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

anti-PITRM1 antibody :: Rabbit anti-Human, Mouse PITRM1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS7043829
Unit / Price
0.05 mL  /  $120 +1 FREE 8GB USB
0.1 mL  /  $160 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

PITRM1, Polyclonal Antibody

★Popular Item★
 Also Known As   

PITRM1 Antibody

 Product Synonym Names    Presequence protease, mitochondrial; hPreP; Pitrilysin metalloproteinase 1; Metalloprotease 1; hMP1; PITRM1; KIAA1104; MP1
 Product Gene Name   

anti-PITRM1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 3D Structure    ModBase 3D Structure for Q5JRX3
 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse
Section Bar
 Purity/Purification    Antigen Affinity Purified
 Form/Format    Liquid
Section Bar
 Species    Human
 Immunogen    Recombinant human Presequence protease, mitochondrial protein (C-280AA)
 Conjugate    Non-conjugated
 Buffer    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-82316
Section Bar
 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-PITRM1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 

Related Product Information for anti-PITRM1 antibody

   ATP-independent protease that degrades mitochondrial transit peptides after their cleavage. Also degrades other unstructured peptides. Specific for peptides in the range of 10 to 65 residues. Able to degrade amyloid beta A4 (APP) protein when it accumulates in mitochondrion, suggesting a link with Alzheimer disease. Shows a preference for cleavage after small polar residues and before basic residues, but without any positional preference.
 Applications Tested/Suitable for anti-PITRM1 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

Section Bar
 Western Blot (WB) of anti-PITRM1 antibody    Western blot
All lanes: PITRM1 antibody at 2ug/ml
Lane 1:mouse placenta tissue
Lane 2:A549 whole cell lysate
Lane 3:mouse kidney tissue
Secondary
Goat polyclonal to rabbit at 1/10000 dilution
Predicted band size: 118,107 kDa
Observed band size: 117 kDa

anti-PITRM1 antibody Western Blot (WB) (WB) image
Section Bar
 Immunohistochemistry (IHC) of anti-PITRM1 antibody    Immunohistochemistry of paraffin-embedded human brain tissue using MBS7043829 at dilution 1:100
anti-PITRM1 antibody Immunohistochemistry (IHC) (IHC) image
Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for PITRM1. It may not necessarily be applicable to this product.
 NCBI GI #    334085248
 NCBI GeneID    10531
 NCBI Accession #    NP_001229236.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001242307.1 [Other Products]
Section Bar
 UniProt Primary Accession #    Q5JRX3 [Other Products]
 UniProt Secondary Accession #    O95204; Q2M2G6; Q4VBR1; Q5JRW7; Q7L5Z7; Q9BSI6; Q9BVJ5; B3KMJ6; B4E0J8; C9JSL2; E7ES23 [Other Products]
 UniProt Related Accession #    Q5JRX3 [Other Products]
 Molecular Weight    106,065 Da
Table BarTOPTable Bar
 NCBI Official Full Name    presequence protease, mitochondrial isoform 1
 NCBI Official Synonym Full Names    pitrilysin metallopeptidase 1
 NCBI Official Symbol    PITRM1 [Similar Products]
 NCBI Official Synonym Symbols   
MP1; PreP
[Similar Products]
 NCBI Protein Information    presequence protease, mitochondrial
 UniProt Protein Name    Presequence protease, mitochondrial
 UniProt Synonym Protein Names   
Pitrilysin metalloproteinase 1; Metalloprotease 1; hMP1
 UniProt Gene Name    PITRM1 [Similar Products]
 UniProt Synonym Gene Names    KIAA1104; MP1; hPreP; Metalloprotease 1; hMP1 [Similar Products]
 UniProt Entry Name    PREP_HUMAN
Section Bar
 UniProt Comments for PITRM1    PITRM1: ATP-independent protease that degrades mitochondrial transit peptides after their cleavage. Also degrades other unstructured peptides. Specific for peptides in the range of 10 to 65 residues. Able to degrade amyloid beta A4 (APP) protein when it accumulates in mitochondrion, suggesting a link with Alzheimer disease. Shows a preference for cleavage after small polar residues and before basic residues, but without any positional preference. Belongs to the peptidase M16 family. PreP subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.4.24.-; Mitochondrial; Protease; Activator

Chromosomal Location of Human Ortholog: 10p15.2

Cellular Component: mitochondrial matrix; mitochondrion

Molecular Function: enzyme activator activity; metalloendopeptidase activity; zinc ion binding

Biological Process: protein processing; proteolysis
Table BarTOPTable Bar
 Research Articles on PITRM1    1. Data show that the hPreP presequence only targets GFP to the matrix of mammalian and yeast mitochondria.
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Diseases associated with anti-PITRM1 antibodyOrgans/Tissues associated with anti-PITRM1 antibody
 Disease Name  Pubmed Publications
 Disease Models, Animal Antibodies  >1 publications with PITRM1 and Disease Models, Animal
 Kidney Diseases Antibodies  >1 publications with PITRM1 and Kidney Diseases
 Mental Disorders Antibodies  >1 publications with PITRM1 and Mental Disorders
 Atrophy Antibodies  >1 publications with PITRM1 and Atrophy
 Body Weight Changes Antibodies  >1 publications with PITRM1 and Body Weight Changes
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >3 publications with PITRM1 and Muscle
 Brain Antibodies  >3 publications with PITRM1 and Brain
 Liver Antibodies  >2 publications with PITRM1 and Liver
 Placenta Antibodies  >2 publications with PITRM1 and Placenta
 Lung Antibodies  >2 publications with PITRM1 and Lung
 Pancreas Antibodies  >1 publications with PITRM1 and Pancreas
 Heart Antibodies  >1 publications with PITRM1 and Heart
 Embryonic Tissue Antibodies  >1 publications with PITRM1 and Embryonic Tissue
 Kidney Antibodies  >1 publications with PITRM1 and Kidney
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions