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anti-PRKCD antibody :: Rabbit PKC Delta Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS352221 anti-PRKCD antibody
Unit / Price
1 Bottle  /  $300 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

PKC Delta (PRKCD), Polyclonal Antibody

 Also Known As   

PKC Delta

 Product Synonym Names    Protein Kinase C d (Human, Rat)
 Product Gene Name   

anti-PRKCD antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 3; NC_000003.11 (53195223..53226733). Location: 3p21.31
 OMIM    176977
 3D Structure    ModBase 3D Structure for Q05655
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 Clonality    Polyclonal
 Host    Rabbit
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 Other Notes    Small volumes of anti-PRKCD antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-PRKCD antibody    RIA Grade Antibodies
 Applications Tested/Suitable for anti-PRKCD antibody   

Radioimmunoassay

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NCBI/Uniprot data below describe general gene information for PRKCD. It may not necessarily be applicable to this product.
 NCBI GI #    47157325
 NCBI GeneID    5580
 NCBI Accession #    NP_997704.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_212539.1 [Other Products]
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 UniProt Primary Accession #    Q05655 [Other Products]
 UniProt Secondary Accession #    Q15144; Q86XJ6; B2R834 [Other Products]
 UniProt Related Accession #    Q05655 [Other Products]
 Molecular Weight    77374 Da [Similar Products]
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 NCBI Official Full Name    protein kinase C delta type
 NCBI Official Synonym Full Names    protein kinase C, delta
 NCBI Official Symbol    PRKCD [Similar Products]
 NCBI Official Synonym Symbols   
MAY1; PKCD; MGC49908; nPKC-delta
[Similar Products]
 NCBI Protein Information    protein kinase C delta type; OTTHUMP00000165024; OTTHUMP00000165025; protein kinase C delta VIII
 UniProt Protein Name    Protein kinase C delta type
 UniProt Synonym Protein Names   
nPKC-delta
 Protein Family    Protein kinase
 UniProt Gene Name    PRKCD [Similar Products]
 UniProt Entry Name    KPCD_HUMAN
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 NCBI Summary for PRKCD    Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. Studies both in human and mice demonstrate that this kinase is involved in B cell signaling and in the regulation of growth, apoptosis, and differentiation of a variety of cell types. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq]
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 UniProt Comments for PRKCD    Function: This is calcium-independent, phospholipid-dependent, serine- and threonine-specific enzyme. PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters. May play a role in antigen-dependent control of B-cell function. Phosphorylates MUC1 in the C-terminal and regulates the interaction between MUC1 and beta-catenin. Ref.8

Catalytic activity: ATP + a protein = ADP + a phosphoprotein.

Enzyme regulation: Three specific sites; Thr-507 (activation loop of the kinase domain), Ser-645 (turn motif) and Ser-664 (hydrophobic region), need to be phosphorylated for its full activation.

Subunit structure: Interacts with PDK1, RAD9A, CDCP1 and MUC1. Ref.8 Ref.9 Ref.21

Subcellular location: Cytoplasm

By similarity. Membrane; Peripheral membrane protein

Domain: The C1 domain, containing the phorbol ester/DAG-type region 1 (C1A) and 2 (C1B), is the diacylglycerol sensor.The C2 domain is a non-calcium binding domain. It binds proteins containing phosphotyrosine in a sequence-specific manner.

Post-translational modification: Phosphorylated on Thr-507, within the activation loop. Autophosphorylated and/or phosphorylated. Although the Thr-507 phosphorylation occurs it is not a prerequisite for enzymatic activity

By similarity. Ref.10 Ref.11 Ref.12 Ref.13 Ref.14 Ref.15 Ref.16 Ref.17 Ref.18 Ref.19

Sequence similarities: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.Contains 1 AGC-kinase C-terminal domain.Contains 1 C2 domain.Contains 2 phorbol-ester/DAG-type zinc fingers.Contains 1 protein kinase domain.
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 Research Articles on PRKCD    1. p23 acts as an anchoring protein that retains PKCdelta at the perinuclear region, thus limiting the availability of this kinase for activation in response to stimuli.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-PRKCD antibodyPathways associated with anti-PRKCD antibody
 Reference Product  PubMed Publications
 SRC antibody  >59 publications with PRKCD and SRC
 MAPK3 antibody  >34 publications with PRKCD and MAPK3
 MAPK1 antibody  >33 publications with PRKCD and MAPK1
 EGFR antibody  >11 publications with PRKCD and EGFR
 STAT1 antibody  >8 publications with PRKCD and STAT1
 STAT3 antibody  >8 publications with PRKCD and STAT3
 IRS1 antibody  >6 publications with PRKCD and IRS1
 PTK2B antibody  >6 publications with PRKCD and PTK2B
 LYN antibody  >6 publications with PRKCD and LYN
 FYN antibody  >5 publications with PRKCD and FYN
 Products by Pathway  Pathway Diagram
 Alpha-synuclein Signaling Pathway antibodies  Alpha-synuclein Signaling Pathway Diagram
 Alpha6-Beta4 Integrin Signaling Pathway antibodies  Alpha6-Beta4 Integrin Signaling Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptotic Cleavage Of Cellular Proteins Pathway antibodies  Apoptotic Cleavage Of Cellular Proteins Pathway Diagram
 Apoptotic Execution Phase Pathway antibodies  Apoptotic Execution Phase Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 Ca-dependent Events Pathway antibodies  Ca-dependent Events Pathway Diagram
 CaM Pathway antibodies  CaM Pathway Diagram
 Calcium Regulation In The Cardiac Cell Pathway antibodies  Calcium Regulation In The Cardiac Cell Pathway Diagram
 Calmodulin Induced Events Pathway antibodies  Calmodulin Induced Events Pathway Diagram
Diseases associated with anti-PRKCD antibodyOrgans/Tissues associated with anti-PRKCD antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >145 publications with PRKCD and Neoplasms
 Cardiovascular Diseases Antibodies  >65 publications with PRKCD and Cardiovascular Diseases
 Heart Diseases Antibodies  >41 publications with PRKCD and Heart Diseases
 Carcinoma Antibodies  >34 publications with PRKCD and Carcinoma
 Leukemia Antibodies  >32 publications with PRKCD and Leukemia
 Drug Toxicity Antibodies  >26 publications with PRKCD and Drug Toxicity
 Neuroectodermal Tumors Antibodies  >25 publications with PRKCD and Neuroectodermal Tumors
 Inflammation Antibodies  >23 publications with PRKCD and Inflammation
 Diabetes Mellitus Antibodies  >20 publications with PRKCD and Diabetes Mellitus
 Hypertrophy Antibodies  >20 publications with PRKCD and Hypertrophy
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >123 publications with PRKCD and Blood
 Heart Antibodies  >80 publications with PRKCD and Heart
 Vascular Antibodies  >66 publications with PRKCD and Vascular
 Brain Antibodies  >64 publications with PRKCD and Brain
 Nerve Antibodies  >34 publications with PRKCD and Nerve
 Kidney Antibodies  >31 publications with PRKCD and Kidney
 Skin Antibodies  >26 publications with PRKCD and Skin
 Liver Antibodies  >23 publications with PRKCD and Liver
 Lung Antibodies  >23 publications with PRKCD and Lung
 Intestine Antibodies  >17 publications with PRKCD and Intestine
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