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anti-PRKCH antibody :: Rabbit PKC Eta (Human) Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS352230 anti-PRKCH antibody
Unit / Price
1 Bottle  /  $300 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

PKC Eta (Human) (PRKCH), Polyclonal Antibody

 Also Known As   

PKC Eta (Human)

 Product Synonym Names    Protein Kinase C h (Human)
 Product Gene Name   

anti-PRKCH antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 14; NC_000014.8 (61788515..62017698). Location: 14q23.1
 OMIM    601367
 3D Structure    ModBase 3D Structure for P24723
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 Clonality    Polyclonal
 Host    Rabbit
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 Other Notes    Small volumes of anti-PRKCH antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-PRKCH antibody    RIA Grade Antibodies
 Applications Tested/Suitable for anti-PRKCH antibody   

Radioimmunoassay

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NCBI/Uniprot data below describe general gene information for PRKCH. It may not necessarily be applicable to this product.
 NCBI GI #    28557781
 NCBI GeneID    5583
 NCBI Accession #    NP_006246.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_006255.3 [Other Products]
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 UniProt Primary Accession #    P24723 [Other Products]
 UniProt Secondary Accession #    Q16246; Q8NE03 [Other Products]
 UniProt Related Accession #    P24723; Q71UV9; Q9BVQ0 [Other Products]
 Molecular Weight    77698 Da [Similar Products]
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 NCBI Official Full Name    protein kinase C eta type
 NCBI Official Synonym Full Names    protein kinase C, eta
 NCBI Official Symbol    PRKCH [Similar Products]
 NCBI Official Synonym Symbols   
PKCL; PKC-L; PRKCL; MGC5363; MGC26269; nPKC-eta
[Similar Products]
 NCBI Protein Information    protein kinase C eta type; OTTHUMP00000179058
 UniProt Protein Name    Protein kinase C eta type
 UniProt Synonym Protein Names   
PKC-L; nPKC-eta
 Protein Family    Protein kinase
 UniProt Gene Name    PRKCH [Similar Products]
 UniProt Synonym Gene Names    PKCL; PRKCL [Similar Products]
 UniProt Entry Name    KPCL_HUMAN
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 NCBI Summary for PRKCH    Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipids-dependent protein kinase. It is predominantly expressed in epithelial tissues and has been shown to reside specifically in the cell nucleus. This protein kinase can regulate keratinocyte differentiation by activating the MAP kinase MAPK13 (p38delta)-activated protein kinase cascade that targets CCAAT/enhancer-binding protein alpha (CEBPA). It is also found to mediate the transcription activation of the transglutaminase 1 (TGM1) gene. [provided by RefSeq]
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 UniProt Comments for PRKCH    Function: This is calcium-independent, phospholipid-dependent, serine- and threonine-specific enzyme.PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters.

Catalytic activity: ATP + a protein = ADP + a phosphoprotein.

Enzyme regulation: Three specific sites; Thr-513 (activation loop of the kinase domain), Thr-656 (turn motif) and Ser-675 (hydrophobic region), need to be phosphorylated for its full activation.

Subunit structure: Interacts with DGKQ. Ref.8

Tissue specificity: Most abundant in lung, less in heart and skin.

Domain: The C1 domain, containing the phorbol ester/DAG-type region 1 (C1A) and 2 (C1B), is the diacylglycerol sensor and the C2 domain is a non-calcium binding domain.

Involvement in disease: Defects in PRKCH may be a cause of susceptibility to ischemic stroke (ISCHSTR) [

MIM:601367]; also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors. Ref.13

Sequence similarities: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.Contains 1 AGC-kinase C-terminal domain.Contains 1 C2 domain.Contains 2 phorbol-ester/DAG-type zinc fingers.Contains 1 protein kinase domain.
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 Research Articles on PRKCH    1. Three different isotypes of protein kinase C, i.e. PKC-alpha, PKC-eta and PKC-theta, were found to be regulated and translocated in opposite directions upon apoptosis induction.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-PRKCH antibodyDiseases associated with anti-PRKCH antibody
 Products by Pathway  Pathway Diagram
 Calcium Regulation In The Cardiac Cell Pathway antibodies  Calcium Regulation In The Cardiac Cell Pathway Diagram
 Effects Of PIP2 Hydrolysis Pathway antibodies  Effects Of PIP2 Hydrolysis Pathway Diagram
 Endothelins Pathway antibodies  Endothelins Pathway Diagram
 Formation Of Platelet Plug Pathway antibodies  Formation Of Platelet Plug Pathway Diagram
 G Protein Signaling Pathways antibodies  G Protein Signaling Pathways Diagram
 G Alpha (q) Signalling Events Pathway antibodies  G Alpha (q) Signalling Events Pathway Diagram
 G Alpha (z) Signalling Events Pathway antibodies  G Alpha (z) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Insulin Signaling Pathway antibodies  Insulin Signaling Pathway Diagram
 Disease Name  Pubmed Publications
 Brain Ischemia Antibodies  >6 publications with PRKCH and Brain Ischemia
 Nervous System Diseases Antibodies  >6 publications with PRKCH and Nervous System Diseases
 Arthritis, Rheumatoid Antibodies  >5 publications with PRKCH and Arthritis, Rheumatoid
 Hypertension Antibodies  >4 publications with PRKCH and Hypertension
 STROKE, ISCHEMIC Antibodies  >4 publications with PRKCH and STROKE, ISCHEMIC
 Autoimmune Diseases Antibodies  >3 publications with PRKCH and Autoimmune Diseases
 Neoplasms Antibodies  >2 publications with PRKCH and Neoplasms
 Myocardial Ischemia Antibodies  >2 publications with PRKCH and Myocardial Ischemia
 Hemorrhage Antibodies  >2 publications with PRKCH and Hemorrhage
 Osteoporosis Antibodies  >2 publications with PRKCH and Osteoporosis
Organs/Tissues associated with anti-PRKCH antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >5 publications with PRKCH and Blood
 Brain Antibodies  >5 publications with PRKCH and Brain
 Vascular Antibodies  >4 publications with PRKCH and Vascular
 Bone Antibodies  >2 publications with PRKCH and Bone
 Ear Antibodies  >1 publications with PRKCH and Ear
 Stomach Antibodies  >1 publications with PRKCH and Stomach
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