NP_006248.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
protein kinase C theta type isoform 1
NCBI Official Synonym Full Names
protein kinase C, theta
NCBI Official Synonym Symbols
PRKCT; MGC126514; MGC141919; nPKC-theta [Similar Products]
NCBI Protein Information
protein kinase C theta type; OTTHUMP00000019053
UniProt Protein Name
Protein kinase C theta type
UniProt Synonym Protein Names
nPKC-theta
UniProt Synonym Gene Names
UniProt Entry Name
KPCT_HUMAN
NCBI Summary for PRKCQ
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipid-dependent protein kinase. This kinase is important for T-cell activation. It is required for the activation of the transcription factors NF-kappaB and AP-1, and may link the T cell receptor (TCR) signaling complex to the activation of the transcription factors. [provided by RefSeq]
UniProt Comments for PRKCQ
Function: This is a calcium-independent, phospholipid-dependent, serine- and threonine-specific enzyme. Essential for T-cell receptor (TCR)-mediated T-cell activation, but is dispensable during TCR-dependent thymocyte development. Links the TCR signaling complex to the activation of NF-kappa-B in mature T lymphocytes. Required for interleukin-2 (IL2) production. Ref.8PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters. Ref.8
Catalytic activity: ATP + a protein = ADP + a phosphoprotein.
Cofactor: Magnesium.
Enzyme regulation: Three specific sites; Thr-538 (activation loop of the kinase domain), Ser-676 (turn motif) and Ser-695 (hydrophobic region), need to be phosphorylated for its full activation.
Subunit structure: Interacts with GLRX3 (via N-terminus). Ref.7
Tissue specificity: Skeletal muscle, megakaryoblastic cells and platelets. Ref.1
Domain: The C1 domain, containing the phorbol ester/DAG-type region 1 (C1A) and 2 (C1B), is the diacylglycerol sensor and the C2 domain is a non-calcium binding domain.
Post-translational modification: Autophosphorylation at Thr-219 is required for targeting to the TCR and cellular function of PKC upon antigen receptor ligation.
Sequence similarities: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.Contains 1 AGC-kinase C-terminal domain.Contains 1 C2 domain.Contains 2 phorbol-ester/DAG-type zinc fingers.Contains 1 protein kinase domain.
Research Articles on PRKCQ
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Products associated with anti-PRKCQ antibody
Pathways associated with anti-PRKCQ antibody
Diseases associated with anti-PRKCQ antibody
Organs/Tissues associated with anti-PRKCQ antibody
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