P17252.3
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
Protein kinase C alpha type
NCBI Official Synonym Full Names
protein kinase C, alpha
NCBI Official Synonym Symbols
AAG6; PKCA; PRKACA; MGC129900; MGC129901; PKC-alpha [Similar Products]
NCBI Protein Information
protein kinase C alpha type; PKC-A; aging-associated gene 6
UniProt Protein Name
Protein kinase C alpha type
UniProt Synonym Gene Names
UniProt Entry Name
KPCA_HUMAN
NCBI Summary for PRKCA
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca(2+) handling in myocytes. [provided by RefSeq]
UniProt Comments for PRKCA
Function: This is a calcium-activated, phospholipid-dependent, serine- and threonine-specific enzyme. May play a role in cell motility by phosphorylating CSPG4. Ref.9PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters. Ref.9
Catalytic activity: ATP + a protein = ADP + a phosphoprotein.
Cofactor: Binds 3 calcium ions per subunit. The ions are bound to the C2 domain
Subunit structure: Recruited in a circadian manner into a nuclear complex which also includes BMAL1 and GNB2L1/RACK1
By similarity. Interacts with ADAP1/CENTA1, CSPG4 and PRKCABP. Binds to SDPR in the presence of phosphatidylserine. Interacts with PICK1 (via PDZ domain). Interacts with TRIM41. Ref.7 Ref.8 Ref.9 Ref.13
Subcellular location: Cytoplasm
By similarity. Cell membrane; Peripheral membrane protein
By similarity. Nucleus
Sequence similarities: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.Contains 1 AGC-kinase C-terminal domain.Contains 1 C2 domain.Contains 2 phorbol-ester/DAG-type zinc fingers.Contains 1 protein kinase domain.
Product References and Citations for anti-PRKCA antibody
• Kawakami et al. (2003) Proc. Natl. Acad. Sci. USA 100:9470-9475. • Nishizuka, Y. (1988) Nature 334:661.
Research Articles on PRKCA
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Products associated with anti-PRKCA antibody
Pathways associated with anti-PRKCA antibody
Diseases associated with anti-PRKCA antibody
Organs/Tissues associated with anti-PRKCA antibody
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