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anti-PRKCQ antibody :: Rabbit PKC theta (Phospho-Ser695) Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9206662
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 Product Name   

PKC theta (Phospho-Ser695) (PRKCQ), Polyclonal Antibody

★Popular Item★
 Also Known As   

PKC theta (Phospho-Ser695) Antibody

 Product Synonym Names    Protein kinase C theta type; nPKC-theta; PRKCQ; PRKCT
 Product Gene Name   

anti-PRKCQ antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    600448
 3D Structure    ModBase 3D Structure for Q04759
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human, mouse, rat
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 Purity/Purification    Purified Rabbit Polyclonal Antibody (Pab)
 Form/Format    Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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 Antigen Type    synthetic peptide
 Antigen Source    HUMAN
 Cellular Location    Cytoplasm. Cell membrane; Peripheral membrane protein. Note=In resting T-cells, mostly localized in cytoplasm. In response to TCR stimulation, associates with lipid rafts and then localizes in the immunological synapse
 Tissue Location    Expressed in skeletal muscle, T-cells, megakaryoblastic cells and platelets
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 Preparation and Storage    store at -20 degree C
 Other Notes    Small volumes of anti-PRKCQ antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-PRKCQ antibody

   Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that mediates non- redundant functions in T-cell receptor (TCR) signaling, including T-cells activation, proliferation, differentiation and survival, by mediating activation of multiple transcription factors such as NF-kappa-B, JUN, NFATC1 and NFATC2. In TCR-CD3/CD28-co-stimulated T-cells, is required for the activation of NF-kappa-B and JUN, which in turn are essential for IL2 production, and participates to the calcium-dependent NFATC1 and NFATC2 transactivation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11 on several serine residues, inducing CARD11 association with lipid rafts and recruitment of the BCL10-MALT1 complex, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1. May also play an indirect role in activation of the non- canonical NF-kappa-B (NFKB2) pathway. In the signaling pathway leading to JUN activation, acts by phosphorylating the mediator STK39/SPAK and may not act through MAP kinases signaling. Plays a critical role in TCR/CD28-induced NFATC1 and NFATC2 transactivation by participating in the regulation of reduced inositol 1,4,5-trisphosphate generation and intracellular calcium mobilization. After costimulation of T-cells through CD28 can phosphorylate CBLB and is required for the ubiquitination and subsequent degradation of CBLB, which is a prerequisite for the activation of TCR. During T-cells differentiation, plays an important role in the development of T-helper 2 (Th2) cells following immune and inflammatory responses, and, in the development of inflammatory autoimmune diseases, is necessary for the activation of IL17-producing Th17 cells. May play a minor role in Th1 response. Upon TCR stimulation, mediates T-cell protective survival signal by phosphorylating BAD, thus protecting T-cells from BAD-induced apoptosis, and by up-regulating BCL-X(L)/BCL2L1 levels through NF-kappa-B and JUN pathways. In platelets, regulates signal transduction downstream of the ITGA2B, CD36/GP4, F2R/PAR1 and F2RL3/PAR4 receptors, playing a positive role in 'outside-in' signaling and granule secretion signal transduction. May relay signals from the activated ITGA2B receptor by regulating the uncoupling of WASP and WIPF1, thereby permitting the regulation of actin filament nucleation and branching activity of the Arp2/3 complex. May mediate inhibitory effects of free fatty acids on insulin signaling by phosphorylating IRS1, which in turn blocks IRS1 tyrosine phosphorylation and downstream activation of the PI3K/AKT pathway. Phosphorylates MSN (moesin) in the presence of phosphatidylglycerol or phosphatidylinositol. Phosphorylates PDPK1 at 'Ser-504' and 'Ser-532' and negatively regulates its ability to phosphorylate PKB/AKT1.
 Product Categories/Family for anti-PRKCQ antibody    Phospho Antibodies
 Applications Tested/Suitable for anti-PRKCQ antibody   

Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-PRKCQ antibody    WB~~1:1000
IHC~~1:50~100
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 Western Blot (WB) of anti-PRKCQ antibody    Western blot analysis of extracts from Jurkat cells, treated with EGF (200ng/ml, 15mins), using PKC theta (Phospho-Ser695) antibody.
anti-PRKCQ antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-PRKCQ antibody    Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue using PKC theta (Phospho-Ser695) antibody.
anti-PRKCQ antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for PRKCQ. It may not necessarily be applicable to this product.
 NCBI GI #    334848126
 NCBI GeneID    5588
 NCBI Accession #    NP_001229342.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001242413.2 [Other Products]
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 UniProt Primary Accession #    Q04759 [Other Products]
 UniProt Secondary Accession #    Q14DH6; Q3MJF1; Q64FY5; Q9H508; Q9H549; B4DF52 [Other Products]
 UniProt Related Accession #    Q04759 [Other Products]
 Molecular Weight    81865
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 NCBI Official Full Name    protein kinase C theta type isoform 2
 NCBI Official Synonym Full Names    protein kinase C, theta
 NCBI Official Symbol    PRKCQ [Similar Products]
 NCBI Official Synonym Symbols   
PRKCT; nPKC-theta
[Similar Products]
 NCBI Protein Information    protein kinase C theta type
 UniProt Protein Name    Protein kinase C theta type
 UniProt Synonym Protein Names   
nPKC-theta
 Protein Family    Protein kinase
 UniProt Gene Name    PRKCQ [Similar Products]
 UniProt Synonym Gene Names    PRKCT [Similar Products]
 UniProt Entry Name    KPCT_HUMAN
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 NCBI Summary for PRKCQ    Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipid-dependent protein kinase. This kinase is important for T-cell activation. It is required for the activation of the transcription factors NF-kappaB and AP-1, and may link the T cell receptor (TCR) signaling complex to the activation of the transcription factors. [provided by RefSeq, Jul 2008]
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 UniProt Comments for PRKCQ    PKCT: an AGC kinase of the PKC family. A novel PKC: Ca2+ independent but still regulated by PS, DAG and phorbol esters. Contains 2 zinc-dependent phorbol-ester and DAG binding domains. Expressed in skeletal muscle and hematopoietic cells. May play a role in T cell receptor signaling and insulin resistance. Required for TCR-induced NF-kappaB activation in mature T lymphocytes.

Protein type: Protein kinase, Ser/Thr (non-receptor); Protein kinase, AGC; Kinase, protein; EC 2.7.11.13; AGC group; PKC family; Delta subfamily

Chromosomal Location of Human Ortholog: 10p15

Cellular Component: plasma membrane; immunological synapse; cytosol

Molecular Function: protein serine/threonine kinase activity; protein binding; protein kinase C activity; metal ion binding; ubiquitin-protein ligase activity; ATP binding

Biological Process: positive regulation of interleukin-17 production; platelet activation; phototransduction, visible light; axon guidance; apoptosis; positive regulation of interleukin-2 biosynthetic process; membrane protein ectodomain proteolysis; protein ubiquitination; negative regulation of insulin receptor signaling pathway; T cell receptor signaling pathway; protein amino acid phosphorylation; activation of NF-kappaB transcription factor; rhodopsin mediated signaling; positive regulation of interleukin-4 production; regulation of rhodopsin mediated signaling; regulation of transcription, DNA-dependent; innate immune response; positive regulation of T cell proliferation; regulation of cell growth; positive regulation of T cell activation; inflammatory response; blood coagulation; cell structure disassembly during apoptosis
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Product References and Citations for anti-PRKCQ antibody

   Chang J.D.,et al.J. Biol. Chem. 268:14208-14214(1993).
Chang J.D.,et al.J. Biol. Chem. 269:31322-31322(1994).
Baier G.,et al.J. Biol. Chem. 268:4997-5004(1993).
Li H.,et al.Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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 Research Articles on PRKCQ    1. Data suggest that protein kinase C theta (PKCtheta;) inhibition alone may be sufficient to drive efficacy in chronic autoimmune and inflammatory diseases.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-PRKCQ antibodyDiseases associated with anti-PRKCQ antibody
 Reference Product  PubMed Publications
 BCL10 antibody  >20 publications with PRKCQ and BCL10
 IKBKB antibody  >19 publications with PRKCQ and IKBKB
 CARD11 antibody  >17 publications with PRKCQ and CARD11
 CHUK antibody  >14 publications with PRKCQ and CHUK
 MALT1 antibody  >11 publications with PRKCQ and MALT1
 PRKCD antibody  >8 publications with PRKCQ and PRKCD
 LCK antibody  >7 publications with PRKCQ and LCK
 PDPK1 antibody  >5 publications with PRKCQ and PDPK1
 MAP3K7 antibody  >1 publications with PRKCQ and MAP3K7
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >31 publications with PRKCQ and Inflammation
 Necrosis Antibodies  >17 publications with PRKCQ and Necrosis
 Arthritis, Rheumatoid Antibodies  >15 publications with PRKCQ and Arthritis, Rheumatoid
 Nervous System Diseases Antibodies  >13 publications with PRKCQ and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >13 publications with PRKCQ and Cardiovascular Diseases
 Neoplasms, Experimental Antibodies  >6 publications with PRKCQ and Neoplasms, Experimental
 Lung Diseases Antibodies  >5 publications with PRKCQ and Lung Diseases
 Fatty Liver Antibodies  >5 publications with PRKCQ and Fatty Liver
 Breast Neoplasms Antibodies  >4 publications with PRKCQ and Breast Neoplasms
 Fibrosis Antibodies  >4 publications with PRKCQ and Fibrosis
Organs/Tissues associated with anti-PRKCQ antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >249 publications with PRKCQ and Blood
 Muscle Antibodies  >53 publications with PRKCQ and Muscle
 Liver Antibodies  >16 publications with PRKCQ and Liver
 Heart Antibodies  >14 publications with PRKCQ and Heart
 Spleen Antibodies  >13 publications with PRKCQ and Spleen
 Lung Antibodies  >13 publications with PRKCQ and Lung
 Thymus Antibodies  >12 publications with PRKCQ and Thymus
 Brain Antibodies  >12 publications with PRKCQ and Brain
 Bone Marrow Antibodies  >7 publications with PRKCQ and Bone Marrow
 Kidney Antibodies  >6 publications with PRKCQ and Kidney
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