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anti-PKM2 antibody :: Rabbit anti-Human PKM2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9405683
Unit / Price
0.05 mL  /  $200 +1 FREE 8GB USB
0.1 mL  /  $255 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

PKM2, Polyclonal Antibody

★Popular Item★
 Also Known As   

PKM2(phospho-Ser37) Antibody

 Product Synonym Names    PKM, PK3, OIP3, PK2
 Product Gene Name   

anti-PKM2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    179050
 3D Structure    ModBase 3D Structure for P14618
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    The antibody detects endogenous level of PKM2 only when phosphorylated at serine 37.
 Purity/Purification    Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
 Form/Format    Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
 Concentration    1.0 mg/ml (lot specific)
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 Immunogen Type    Peptide-KLH
 Immunogen Description    Peptide sequence around phosphorylation site of serine 37(I-D-S(p)-P-P) derived from Human PKM2.
 Modification    Phospho-Ser37
 Target Name    PKM2
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 Preparation and Storage    Store at -20 degree C
 Other Notes    Small volumes of anti-PKM2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-PKM2 antibody

   Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor cells. The ratio betwween the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival.
 Product Categories/Family for anti-PKM2 antibody    Phospho-specific Ab
 Applications Tested/Suitable for anti-PKM2 antibody   

Western Blot (WB), Immunofluorescence (IF)

 Application Notes for anti-PKM2 antibody    Western Blot: 1:500~1000
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 Western Blot (WB) of anti-PKM2 antibody    Western blot analysis of in vitro kinase assays carried out with puried active ERK2, wild-type (WT) PKM2 and PKM2 S37A mutant using PKM2(phospho-Ser37)Antibody.
anti-PKM2 antibody Western Blot (WB) (WB) image
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 Immunofluorescence (IF) of anti-PKM2 antibody    Immunofluorescence staining of methanol-fixed MEF cells using PKM2 (phospho-Ser37) Antibody.
anti-PKM2 antibody Immunofluorescence (IF) image
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NCBI/Uniprot data below describe general gene information for PKM2. It may not necessarily be applicable to this product.
 NCBI GI #    332164775
 NCBI GeneID    5315
 NCBI Accession #    NP_001193725.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001206796.1 [Other Products]
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 UniProt Primary Accession #    P14618 [Other Products]
 UniProt Secondary Accession #    P14786; Q53GK4; Q96E76; Q9BWB5; Q9UCV6; Q9UPF2; A6NFK3; B2R5N8; B3KRY0; B4DFX8; B4DUU6 [Other Products]
 UniProt Related Accession #    P14618 [Other Products]
 Molecular Weight    56,273 Da
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 NCBI Official Full Name    pyruvate kinase PKM isoform c
 NCBI Official Synonym Full Names    pyruvate kinase, muscle
 NCBI Official Symbol    PKM [Similar Products]
 NCBI Official Synonym Symbols   
PK3; TCB; OIP3; PKM2; CTHBP; THBP1; HEL-S-30
[Similar Products]
 NCBI Protein Information    pyruvate kinase PKM
 UniProt Protein Name    Pyruvate kinase PKM
 UniProt Synonym Protein Names   
Cytosolic thyroid hormone-binding protein; CTHBP; Opa-interacting protein 3; OIP-3; Pyruvate kinase 2/3; Pyruvate kinase muscle isozyme; Thyroid hormone-binding protein 1; THBP1; Tumor M2-PK; p58
 UniProt Gene Name    PKM [Similar Products]
 UniProt Synonym Gene Names    OIP3; PK2; PK3; PKM2; CTHBP; OIP-3; THBP1 [Similar Products]
 UniProt Entry Name    KPYM_HUMAN
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 NCBI Summary for PKM2    This gene encodes a protein involved in glycolysis. The encoded protein is a pyruvate kinase that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate to ADP, generating ATP and pyruvate. This protein has been shown to interact with thyroid hormone and may mediate cellular metabolic effects induced by thyroid hormones. This protein has been found to bind Opa protein, a bacterial outer membrane protein involved in gonococcal adherence to and invasion of human cells, suggesting a role of this protein in bacterial pathogenesis. Several alternatively spliced transcript variants encoding a few distinct isoforms have been reported. [provided by RefSeq, May 2011]
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 UniProt Comments for PKM2    Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor cells. The ratio between the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival.
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 Research Articles on PKM2    1. Results show that PKM2 over-expression in human hepatocellular carcinoma was associated with down-regulation of its regulator mir-122 resulting in an aggressive clinicopathological features and poor prognosis.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-PKM2 antibodyDiseases associated with anti-PKM2 antibody
 Products by Pathway  Pathway Diagram
 Adenine Ribonucleotide Biosynthesis, IMP => ADP,ATP Pathway antibodies  Adenine Ribonucleotide Biosynthesis, IMP => ADP,ATP Pathway Diagram
 Adenine Ribonucleotide Biosynthesis, IMP => ADP,ATP Pathway antibodies  Adenine Ribonucleotide Biosynthesis, IMP => ADP,ATP Pathway Diagram
 Biosynthesis Of Amino Acids Pathway antibodies  Biosynthesis Of Amino Acids Pathway Diagram
 Biosynthesis Of Amino Acids Pathway antibodies  Biosynthesis Of Amino Acids Pathway Diagram
 Biosynthesis Of Antibiotics Pathway antibodies  Biosynthesis Of Antibiotics Pathway Diagram
 Carbon Metabolism Pathway antibodies  Carbon Metabolism Pathway Diagram
 Carbon Metabolism Pathway antibodies  Carbon Metabolism Pathway Diagram
 Central Carbon Metabolism In Cancer Pathway antibodies  Central Carbon Metabolism In Cancer Pathway Diagram
 Central Carbon Metabolism In Cancer Pathway antibodies  Central Carbon Metabolism In Cancer Pathway Diagram
 Glucagon Signaling Pathway antibodies  Glucagon Signaling Pathway Diagram
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >14 publications with PKM2 and Nervous System Diseases
 Fibrosis Antibodies  >8 publications with PKM2 and Fibrosis
 Lung Diseases Antibodies  >8 publications with PKM2 and Lung Diseases
 Inflammation Antibodies  >7 publications with PKM2 and Inflammation
 Cardiovascular Diseases Antibodies  >7 publications with PKM2 and Cardiovascular Diseases
 Carcinoma Antibodies  >6 publications with PKM2 and Carcinoma
 Cell Transformation, Neoplastic Antibodies  >5 publications with PKM2 and Cell Transformation, Neoplastic
 Necrosis Antibodies  >4 publications with PKM2 and Necrosis
 Liver Diseases Antibodies  >4 publications with PKM2 and Liver Diseases
 Disease Models, Animal Antibodies  >3 publications with PKM2 and Disease Models, Animal
Organs/Tissues associated with anti-PKM2 antibody
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >61 publications with PKM2 and Brain
 Blood Antibodies  >42 publications with PKM2 and Blood
 Muscle Antibodies  >28 publications with PKM2 and Muscle
 Kidney Antibodies  >15 publications with PKM2 and Kidney
 Liver Antibodies  >15 publications with PKM2 and Liver
 Heart Antibodies  >11 publications with PKM2 and Heart
 Nerve Antibodies  >10 publications with PKM2 and Nerve
 Vascular Antibodies  >9 publications with PKM2 and Vascular
 Lung Antibodies  >7 publications with PKM2 and Lung
 Thyroid Antibodies  >7 publications with PKM2 and Thyroid
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