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anti-PLAUR antibody :: Rabbit PLAUR Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2524126
Unit / Price
0.02 mL  /  $110 +1 FREE 8GB USB
0.06 mL  /  $150 +1 FREE 8GB USB
0.12 mL  /  $225 +1 FREE 8GB USB
0.2 mL  /  $360 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

PLAUR, Polyclonal Antibody

★Popular Item★
 Also Known As   

PLAUR Polyclonal Antibody

 Product Synonym Names    CD87; UPAR; URKR; U-PAR
 Product Gene Name   

anti-PLAUR antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    173391
 3D Structure    ModBase 3D Structure for Q03405
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Antigen affinity purification
 Concentration    1.8mg/mL (lot specific)
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 Immunogen    Recombinant protein of human PLAUR
 Calculated Molecular Weight: 37kDa   
 Buffer    PBS with 0.05% sodium azide, 50% glycerol, pH7.3
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 Preparation and Storage    Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-PLAUR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-PLAUR antibody

   This gene encodes the receptor for urokinase plasminogen activator and, given its role in localizing and promoting plasmin formation, likely influences many normal and pathological processes related to cell-surface plasminogen activation and localized degradation of the extracellular matrix. It binds both the proprotein and mature forms of urokinase plasminogen activator and permits the activation of the receptor-bound pro-enzyme by plasmin. The protein lacks transmembrane or cytoplasmic domains and may be anchored to the plasma membrane by a glycosyl-phosphatidylinositol (GPI) moiety following cleavage of the nascent polypeptide near its carboxy-terminus. However, a soluble protein is also produced in some cell types. Alternative splicing results in multiple transcript variants encoding different isoforms. The proprotein experiences several post-translational cleavage reactions that have not yet been fully defined.
 Applications Tested/Suitable for anti-PLAUR antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-PLAUR antibody    WB: 1:500-1:2000
IHC: 1:50-1:200
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 Western Blot (WB) of anti-PLAUR antibody    Western Blot analysis of A549 cell using PLAUR Polyclonal Antibody at dilution of 1:450
anti-PLAUR antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-PLAUR antibody    Immunohistochemistry of paraffin-embedded Human lung cancer using PLAUR Polyclonal Antibody at dilution of 1:60
anti-PLAUR antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-PLAUR antibody    Immunohistochemistry of paraffin-embedded Human cervical cancer using PLAUR Polyclonal Antibody at dilution of 1:60
anti-PLAUR antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for PLAUR. It may not necessarily be applicable to this product.
 NCBI GI #    48146021
 NCBI GeneID    5329
 NCBI Accession #    CAG33233.1 [Other Products]
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 UniProt Primary Accession #    Q03405 [Other Products]
 UniProt Secondary Accession #    Q12876; Q15845; Q16887; Q6IB52; Q9BWT0; Q9NYC8; Q9UD69; Q9UEA6; Q9UM92; Q9UMV0; A8K409 [Other Products]
 UniProt Related Accession #    Q03405 [Other Products]
 Molecular Weight    32,016 Da
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 NCBI Official Full Name    PLAUR
 NCBI Official Synonym Full Names    plasminogen activator, urokinase receptor
 NCBI Official Symbol    PLAUR [Similar Products]
 NCBI Official Synonym Symbols   
CD87; UPAR; URKR; U-PAR
[Similar Products]
 NCBI Protein Information    urokinase plasminogen activator surface receptor; monocyte activation antigen Mo3; u-plasminogen activator receptor form 2; urokinase-type plasminogen activator (uPA) receptor
 UniProt Protein Name    Urokinase plasminogen activator surface receptor
 UniProt Synonym Protein Names   
Monocyte activation antigen Mo3; CD_antigen: CD87
 Protein Family    Urokinase plasminogen activator surface receptor
 UniProt Gene Name    PLAUR [Similar Products]
 UniProt Synonym Gene Names    MO3; UPAR; U-PAR; uPAR [Similar Products]
 UniProt Entry Name    UPAR_HUMAN
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 NCBI Summary for PLAUR    This gene encodes the receptor for urokinase plasminogen activator and, given its role in localizing and promoting plasmin formation, likely influences many normal and pathological processes related to cell-surface plasminogen activation and localized degradation of the extracellular matrix. It binds both the proprotein and mature forms of urokinase plasminogen activator and permits the activation of the receptor-bound pro-enzyme by plasmin. The protein lacks transmembrane or cytoplasmic domains and may be anchored to the plasma membrane by a glycosyl-phosphatidylinositol (GPI) moiety following cleavage of the nascent polypeptide near its carboxy-terminus. However, a soluble protein is also produced in some cell types. Alternative splicing results in multiple transcript variants encoding different isoforms. The proprotein experiences several post-translational cleavage reactions that have not yet been fully defined. [provided by RefSeq, Jul 2008]
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 UniProt Comments for PLAUR    uPAR: Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form. Monomer (Probable). Interacts with MRC2. Interacts (via the UPAR/Ly6 domains) with SRPX2. Expressed in neurons of the rolandic area of the brain. Expressed in the brain. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Membrane protein, GPI anchor; Receptor, misc.

Chromosomal Location of Human Ortholog: 19q13

Cellular Component: endoplasmic reticulum membrane; focal adhesion; extrinsic to membrane; integral to plasma membrane; endoplasmic reticulum lumen; plasma membrane; integral to membrane

Molecular Function: protein domain specific binding; protein binding; U-plasminogen activator receptor activity; enzyme binding; receptor activity; receptor binding

Biological Process: fibrinolysis; cellular protein metabolic process; attachment of GPI anchor to protein; regulation of proteolysis; C-terminal protein lipidation; blood coagulation; post-translational protein modification; signal transduction; cell motility; chemotaxis
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 Research Articles on PLAUR    1. Soluble urokinase plasminogen activator receptor is a sensitive and specific independent predictive biomarkers in preterm babies with bronchopulmonary dysplasia.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-PLAUR antibodyDiseases associated with anti-PLAUR antibody
 Products by Pathway  Pathway Diagram
 Arf6 Downstream Pathway antibodies  Arf6 Downstream Pathway Diagram
 Attachment Of GPI Anchor To UPAR Pathway antibodies  Attachment Of GPI Anchor To UPAR Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Dissolution Of Fibrin Clot Pathway antibodies  Dissolution Of Fibrin Clot Pathway Diagram
 FGF Signaling Pathway antibodies  FGF Signaling Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Post-translational Modification: Synthesis Of GPI-anchored Proteins Pathway antibodies  Post-translational Modification: Synthesis Of GPI-anchored Proteins Pathway Diagram
 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >314 publications with PLAUR and Carcinoma
 Neoplasm Invasiveness Antibodies  >262 publications with PLAUR and Neoplasm Invasiveness
 Neoplasm Metastasis Antibodies  >240 publications with PLAUR and Neoplasm Metastasis
 Breast Neoplasms Antibodies  >165 publications with PLAUR and Breast Neoplasms
 Inflammation Antibodies  >115 publications with PLAUR and Inflammation
 Lung Diseases Antibodies  >91 publications with PLAUR and Lung Diseases
 Cardiovascular Diseases Antibodies  >83 publications with PLAUR and Cardiovascular Diseases
 Lung Neoplasms Antibodies  >76 publications with PLAUR and Lung Neoplasms
 Neoplasms, Experimental Antibodies  >75 publications with PLAUR and Neoplasms, Experimental
 Disease Models, Animal Antibodies  >68 publications with PLAUR and Disease Models, Animal
Organs/Tissues associated with anti-PLAUR antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >507 publications with PLAUR and Blood
 Vascular Antibodies  >303 publications with PLAUR and Vascular
 Lung Antibodies  >148 publications with PLAUR and Lung
 Muscle Antibodies  >98 publications with PLAUR and Muscle
 Brain Antibodies  >86 publications with PLAUR and Brain
 Liver Antibodies  >83 publications with PLAUR and Liver
 Bone Antibodies  >81 publications with PLAUR and Bone
 Embryonic Tissue Antibodies  >80 publications with PLAUR and Embryonic Tissue
 Kidney Antibodies  >77 publications with PLAUR and Kidney
 Skin Antibodies  >68 publications with PLAUR and Skin
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