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anti-PLC gamma 1 antibody :: Rabbit PLC gamma 1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS857171
Testing Data
Unit / Price
0.1 mg  /  $215 +1 FREE 8GB USB
0.05 mg  /  $225 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

PLC gamma 1, Polyclonal Antibody

★Popular Item★
 Also Known As   

PLC gamma 1 (Phospho-Tyr783) Antibody

 Product Synonym Names    PLCg1 (Phospho-Tyr783) Antibody
 Product Gene Name   

anti-PLC gamma 1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    172420
 3D Structure    ModBase 3D Structure for P19174
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Specificity    PLCgamma1 (phospho-Tyr783) antibody detects endogenous levels of PLCgamma1 only when phosphorylated at tyrosine 783.
 Purity/Purification    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation
 Form/Format    Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
 Concentration    50ug/50ul (lot specific)
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 Immunogen    The antiserum was produced against synthesized phosphopeptide derived from human PLCgamma1 around the phosphorylation site of tyrosine 783 (G-F-YP-V-E).
 Pathway    NF-kappa B, Receptors, Kinase/Phosphatases
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 Preparation and Storage    Store at -20 degree C for 1 year
 Other Notes    Small volumes of anti-PLC gamma 1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-PLC gamma 1 antibody    Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody
 Applications Tested/Suitable for anti-PLC gamma 1 antibody   

Western Blot (WB)

 Application Notes for anti-PLC gamma 1 antibody    WB: 1:500~1:1000
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 Testing Data of anti-PLC gamma 1 antibody    Western blot analysis of extract from A431 cells, untreated or treated with EGF (200ng/ml, 10min), using PLCgamma1 (Ab-783) antibody and PLCgamma1 (phospho-Tyr783) antibody (E011103, Lane 3 and 4).
anti-PLC gamma 1 antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for PLC gamma 1. It may not necessarily be applicable to this product.
 NCBI GI #    33598948
 NCBI GeneID    5335
 NCBI Accession #    NP_002651.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_002660.2 [Other Products]
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 UniProt Primary Accession #    P19174 [Other Products]
 UniProt Secondary Accession #    Q2V575; B7ZLY7; B9EGH4; E1P5W4 [Other Products]
 UniProt Related Accession #    P19174 [Other Products]
 Molecular Weight    148,660 Da
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 NCBI Official Full Name    1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform a
 NCBI Official Synonym Full Names    phospholipase C, gamma 1
 NCBI Official Symbol    PLCG1 [Similar Products]
 NCBI Official Synonym Symbols   
PLC1; NCKAP3; PLC-II; PLC148; PLCgamma1
[Similar Products]
 NCBI Protein Information    1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1; PLC-148; PLC-gamma-1; phospholipase C-II; phospholipase C-148; phosphoinositidase C; phospholipase C-gamma-1; inositoltrisphosphohydrolase; phosphoinositide phospholipase C; phosphatidylinositol phospholipase C; triphosphoinositide phosphodiesterase; phosphoinositide phospholipase C-gamma-1; monophosphatidylinositol phosphodiesterase; 1-phosphatidyl-D-myo-inositol-4,5-bisphosphate; phospholipase C, gamma 1 (formerly subtype 148); 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1
 UniProt Protein Name    1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
 UniProt Synonym Protein Names   
PLC-148; Phosphoinositide phospholipase C-gamma-1; Phospholipase C-II; PLC-II; Phospholipase C-gamma-1; PLC-gamma-1
 UniProt Gene Name    PLCG1 [Similar Products]
 UniProt Synonym Gene Names    PLC1; PLC-II; PLC-gamma-1 [Similar Products]
 UniProt Entry Name    PLCG1_HUMAN
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 NCBI Summary for PLC gamma 1    The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. For example, when activated by SRC, the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi, where it activates Ras. Also, this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for PLC gamma 1    PLCG1: a calcium dependent phosphatidylinositol-specific phospholipase C. The activated enzyme produces the second messenger molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylated and activated by tyrosine kinases in response to signaling through a variety of growth factor receptors and immune system receptors.

Protein type: Phospholipase; Carbohydrate Metabolism - inositol phosphate; EC 3.1.4.11; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 20q12-q13.1

Cellular Component: signalosome; ruffle; cell projection; lamellipodium; cytoplasm; plasma membrane; intercellular junction; cytosol

Molecular Function: protein binding; glutamate receptor binding; neurotrophin TRKA receptor binding; receptor signaling protein activity; calcium ion binding; receptor tyrosine kinase binding; protein kinase binding; phospholipase C activity; phosphoinositide phospholipase C activity

Biological Process: epidermal growth factor receptor signaling pathway; axon guidance; cell migration; inositol phosphate metabolic process; fibroblast growth factor receptor signaling pathway; activation of MAPKK activity; nerve growth factor receptor signaling pathway; viral reproduction; phospholipid catabolic process; in utero embryonic development; cytokine and chemokine mediated signaling pathway; positive regulation of blood vessel endothelial cell migration; calcium-mediated signaling; signal transduction; T cell receptor signaling pathway; positive regulation of angiogenesis; phospholipase C activation; innate immune response; positive regulation of release of sequestered calcium ion into cytosol; vascular endothelial growth factor receptor signaling pathway; blood coagulation; leukocyte migration
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Product References and Citations for anti-PLC gamma 1 antibody

   DeBell KE, et al. Mol Cell Biol. 1999 Nov; 19(11): 7388-7398.
Ver- MC, et al. Mol Cell Biol. 2001 Oct; 21(20): 6939-6950.
Sette C, et al. EMBO J. 2002 Oct 15; 21(20): 5386-5395.
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 Research Articles on PLC gamma 1    1. A portion of PLC-gamma1 phosphorylated on tyrosine 783 is not found at LAT-containing clusters but instead is located at TCR-containing clusters.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-PLC gamma 1 antibodyPathways associated with anti-PLC gamma 1 antibody
 Reference Product  PubMed Publications
 LAT antibody  >5 publications with PLC gamma 1 and LAT
 GRB2 antibody  >4 publications with PLC gamma 1 and GRB2
 EGFR antibody  >4 publications with PLC gamma 1 and EGFR
 SOS1 antibody  >2 publications with PLC gamma 1 and SOS1
 FGFR1 antibody  >2 publications with PLC gamma 1 and FGFR1
 NTRK1 antibody  >1 publications with PLC gamma 1 and NTRK1
 CBL antibody  >1 publications with PLC gamma 1 and CBL
 PDGFRB antibody  >1 publications with PLC gamma 1 and PDGFRB
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Angiogenesis Pathway antibodies  Angiogenesis Pathway Diagram
 Antigen Activates B Cell Receptor (BCR) Leading To Generation Of Second Messengers Pathway antibodies  Antigen Activates B Cell Receptor (BCR) Leading To Generation Of Second Messengers Pathway Diagram
 Antiviral Mechanism By IFN-stimulated Genes Pathway antibodies  Antiviral Mechanism By IFN-stimulated Genes Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 BDNF Signaling Pathway antibodies  BDNF Signaling Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Cell Surface Interactions At The Vascular Wall Pathway antibodies  Cell Surface Interactions At The Vascular Wall Pathway Diagram
Diseases associated with anti-PLC gamma 1 antibodyOrgans/Tissues associated with anti-PLC gamma 1 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >7 publications with PLC gamma 1 and Inflammation
 Cardiovascular Diseases Antibodies  >4 publications with PLC gamma 1 and Cardiovascular Diseases
 Necrosis Antibodies  >3 publications with PLC gamma 1 and Necrosis
 Heart Diseases Antibodies  >2 publications with PLC gamma 1 and Heart Diseases
 Brain Diseases Antibodies  >2 publications with PLC gamma 1 and Brain Diseases
 Depressive Disorder Antibodies  >1 publications with PLC gamma 1 and Depressive Disorder
 Seizures Antibodies  >1 publications with PLC gamma 1 and Seizures
 Liver Diseases Antibodies  >1 publications with PLC gamma 1 and Liver Diseases
 Fatty Liver Antibodies  >1 publications with PLC gamma 1 and Fatty Liver
 Prenatal Exposure Delayed Effects Antibodies  >1 publications with PLC gamma 1 and Prenatal Exposure Delayed Effects
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >19 publications with PLC gamma 1 and Blood
 Vascular Antibodies  >9 publications with PLC gamma 1 and Vascular
 Brain Antibodies  >8 publications with PLC gamma 1 and Brain
 Bone Antibodies  >7 publications with PLC gamma 1 and Bone
 Liver Antibodies  >6 publications with PLC gamma 1 and Liver
 Muscle Antibodies  >6 publications with PLC gamma 1 and Muscle
 Heart Antibodies  >4 publications with PLC gamma 1 and Heart
 Lung Antibodies  >3 publications with PLC gamma 1 and Lung
 Kidney Antibodies  >3 publications with PLC gamma 1 and Kidney
 Skin Antibodies  >3 publications with PLC gamma 1 and Skin
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