Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Antibody rightarrow PLC-gamma 1 rightarrow Polyclonal PLC-gamma 1  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • Integrin, beta8 (ITGB8) Antibody
 • Growth arrest-specific protein 6 (GAS6) Recombinant Protein
 • SORD Recombinant Protein
 • six transmembrane epithelial antigen of the prostate 2 Antibody
 • Hepatitis C Virus NS3 Genotype-2b (HCV) Recombinant Protein
 • histidyl-tRNA synthetase (HARS) ELISA Kit
 • H3R17me1 Antibody
 • Extracellular calcium-sensing receptor (CASR) Antibody
 • L- alpha-Methyl DOPA Dimethyl Ether Hydrochloride Biochemical
 • MAD1L1 Antibody
 • Rubella Virus Grade 2 Antigen
 • p107 Antibody
 • FGFR-3 Antibody
 • C-EBP-alpha (Ab-21) Antibody
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

anti-PLC-gamma 1 antibody :: Rabbit PLC-gamma 1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS857329
Unit / Price
0.05 mg  /  $180 +1 FREE 8GB USB
0.1 mg  /  $215 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

PLC-gamma 1, Polyclonal Antibody

 Also Known As   

PLC-gamma 1 (Ab-771) Antibody

 Product Synonym Names    PLC-g1 (Ab-771) Antibody
 Product Gene Name   

anti-PLC-gamma 1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 OMIM    172420
 3D Structure    ModBase 3D Structure for P19174
Section Bar
 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
Section Bar
 Specificity    PLC-gamma1 (Ab-771) Antibody detects endogenous levels of total PLC-gamma1 protein.
 Purity/Purification    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
 Form/Format    Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
 Concentration    50ug/50ul (lot specific)
Section Bar
 Immunogen    The antiserum was produced against synthesized non-phosphopeptide derived from human PLC-gamma1 around the phosphorylation site of tyrosine 771 (P-D-YP-G-A).
 Pathway    NF-kappa B, Kinase/Phosphatases, Neuroscience
Section Bar
 Preparation and Storage    Store at -20 degree C for 1 year
 Other Notes    Small volumes of anti-PLC-gamma 1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 Product Categories/Family for anti-PLC-gamma 1 antibody    Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody
 Applications Tested/Suitable for anti-PLC-gamma 1 antibody   

Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-PLC-gamma 1 antibody    WB: 1:500~1:1000, IHC:1:50~1:100
Section Bar
 Testing Data of anti-PLC-gamma 1 antibody    Peptide - +
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using PLC-gamma1 (Ab-771) Antibody (E021523).
anti-PLC-gamma 1 antibody Testing Data image
Section Bar
 Testing Data #2 of anti-PLC-gamma 1 antibody    Western blot analysis of extracts from 293 cell using PLC-gamma1 (Ab-771) Antibody (E021523, Lane 1 and 2)
anti-PLC-gamma 1 antibody Testing Data #2 image
Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for PLC-gamma 1. It may not necessarily be applicable to this product.
 NCBI GI #    33598948
 NCBI GeneID    5335
 NCBI Accession #    NP_002651.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_002660.2 [Other Products]
Section Bar
 UniProt Primary Accession #    P19174 [Other Products]
 UniProt Secondary Accession #    Q2V575; B7ZLY7; B9EGH4; E1P5W4 [Other Products]
 UniProt Related Accession #    P19174 [Other Products]
 Molecular Weight    148,660 Da
Table BarTOPTable Bar
 NCBI Official Full Name    1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform a
 NCBI Official Synonym Full Names    phospholipase C, gamma 1
 NCBI Official Symbol    PLCG1 [Similar Products]
 NCBI Official Synonym Symbols   
PLC1; NCKAP3; PLC-II; PLC148; PLCgamma1
[Similar Products]
 NCBI Protein Information    1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1; PLC-148; PLC-gamma-1; phospholipase C-II; phospholipase C-148; phosphoinositidase C; phospholipase C-gamma-1; inositoltrisphosphohydrolase; phosphoinositide phospholipase C; phosphatidylinositol phospholipase C; triphosphoinositide phosphodiesterase; phosphoinositide phospholipase C-gamma-1; monophosphatidylinositol phosphodiesterase; 1-phosphatidyl-D-myo-inositol-4,5-bisphosphate; phospholipase C, gamma 1 (formerly subtype 148); 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1
 UniProt Protein Name    1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
 UniProt Synonym Protein Names   
PLC-148; Phosphoinositide phospholipase C-gamma-1; Phospholipase C-II; PLC-II; Phospholipase C-gamma-1; PLC-gamma-1
 UniProt Gene Name    PLCG1 [Similar Products]
 UniProt Synonym Gene Names    PLC1; PLC-II; PLC-gamma-1 [Similar Products]
 UniProt Entry Name    PLCG1_HUMAN
Section Bar
 NCBI Summary for PLC-gamma 1    The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. For example, when activated by SRC, the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi, where it activates Ras. Also, this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Section Bar
 UniProt Comments for PLC-gamma 1    PLCG1: a calcium dependent phosphatidylinositol-specific phospholipase C. The activated enzyme produces the second messenger molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylated and activated by tyrosine kinases in response to signaling through a variety of growth factor receptors and immune system receptors.

Protein type: Carbohydrate Metabolism - inositol phosphate; Motility/polarity/chemotaxis; EC 3.1.4.11; Phospholipase

Chromosomal Location of Human Ortholog: 20q12-q13.1

Cellular Component: signalosome; ruffle; cell projection; lamellipodium; cytoplasm; plasma membrane; intercellular junction; cytosol

Molecular Function: protein binding; glutamate receptor binding; neurotrophin TRKA receptor binding; receptor signaling protein activity; calcium ion binding; receptor tyrosine kinase binding; protein kinase binding; phosphoinositide phospholipase C activity; phospholipase C activity

Biological Process: epidermal growth factor receptor signaling pathway; axon guidance; cell migration; fibroblast growth factor receptor signaling pathway; inositol phosphate metabolic process; activation of MAPKK activity; nerve growth factor receptor signaling pathway; viral reproduction; in utero embryonic development; phospholipid catabolic process; cytokine and chemokine mediated signaling pathway; positive regulation of blood vessel endothelial cell migration; calcium-mediated signaling; signal transduction; T cell receptor signaling pathway; positive regulation of angiogenesis; phospholipase C activation; innate immune response; positive regulation of release of sequestered calcium ion into cytosol; vascular endothelial growth factor receptor signaling pathway; blood coagulation; leukocyte migration
Table BarTOPTable Bar
 

Product References and Citations for anti-PLC-gamma 1 antibody

   Singer, W. D. et al. (1997) Annu. Rev. Biochem. 66, 475-509.
Yue, C. et al. (1998) J. Biol. Chem. 273, 18023-18027.
Wang, Z. et al. (1998) Mol. Cell. Biol. 18, 590-597.
Kim, H. K. et al. (1991) Cell 65, 435-441.
Margolis, B. et al. (1989) Cell 57, 1101-1107.
Section Bar
 Research Articles on PLC-gamma 1    1. A portion of PLC-gamma1 phosphorylated on tyrosine 783 is not found at LAT-containing clusters but instead is located at TCR-containing clusters.
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with anti-PLC-gamma 1 antibodyPathways associated with anti-PLC-gamma 1 antibody
 Reference Product  PubMed Publications
 LAT antibody  >5 publications with PLC-gamma 1 and LAT
 GRB2 antibody  >4 publications with PLC-gamma 1 and GRB2
 EGFR antibody  >4 publications with PLC-gamma 1 and EGFR
 SOS1 antibody  >2 publications with PLC-gamma 1 and SOS1
 FGFR1 antibody  >2 publications with PLC-gamma 1 and FGFR1
 NTRK1 antibody  >1 publications with PLC-gamma 1 and NTRK1
 CBL antibody  >1 publications with PLC-gamma 1 and CBL
 PDGFRB antibody  >1 publications with PLC-gamma 1 and PDGFRB
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Angiogenesis Pathway antibodies  Angiogenesis Pathway Diagram
 Antigen Activates B Cell Receptor (BCR) Leading To Generation Of Second Messengers Pathway antibodies  Antigen Activates B Cell Receptor (BCR) Leading To Generation Of Second Messengers Pathway Diagram
 Antiviral Mechanism By IFN-stimulated Genes Pathway antibodies  Antiviral Mechanism By IFN-stimulated Genes Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 BDNF Signaling Pathway antibodies  BDNF Signaling Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Cell Surface Interactions At The Vascular Wall Pathway antibodies  Cell Surface Interactions At The Vascular Wall Pathway Diagram
Diseases associated with anti-PLC-gamma 1 antibodyOrgans/Tissues associated with anti-PLC-gamma 1 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >7 publications with PLC-gamma 1 and Inflammation
 Cardiovascular Diseases Antibodies  >4 publications with PLC-gamma 1 and Cardiovascular Diseases
 Necrosis Antibodies  >3 publications with PLC-gamma 1 and Necrosis
 Heart Diseases Antibodies  >2 publications with PLC-gamma 1 and Heart Diseases
 Brain Diseases Antibodies  >2 publications with PLC-gamma 1 and Brain Diseases
 Depressive Disorder Antibodies  >1 publications with PLC-gamma 1 and Depressive Disorder
 Seizures Antibodies  >1 publications with PLC-gamma 1 and Seizures
 Liver Diseases Antibodies  >1 publications with PLC-gamma 1 and Liver Diseases
 Fatty Liver Antibodies  >1 publications with PLC-gamma 1 and Fatty Liver
 Prenatal Exposure Delayed Effects Antibodies  >1 publications with PLC-gamma 1 and Prenatal Exposure Delayed Effects
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >19 publications with PLC-gamma 1 and Blood
 Vascular Antibodies  >9 publications with PLC-gamma 1 and Vascular
 Brain Antibodies  >8 publications with PLC-gamma 1 and Brain
 Bone Antibodies  >7 publications with PLC-gamma 1 and Bone
 Liver Antibodies  >6 publications with PLC-gamma 1 and Liver
 Muscle Antibodies  >6 publications with PLC-gamma 1 and Muscle
 Heart Antibodies  >4 publications with PLC-gamma 1 and Heart
 Lung Antibodies  >3 publications with PLC-gamma 1 and Lung
 Kidney Antibodies  >3 publications with PLC-gamma 1 and Kidney
 Skin Antibodies  >3 publications with PLC-gamma 1 and Skin
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions