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anti-PLK3 antibody :: Rabbit anti-Human, Rat PLK3 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS7045722
Unit / Price
0.05 mL  /  $120 +1 FREE 8GB USB
0.1 mL  /  $160 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

PLK3, Polyclonal Antibody

★Popular Item★
 Also Known As   

PLK3 Antibody

 Product Synonym Names    Serine/threonine-protein kinase PLK3; Cytokine-inducible serine/threonine-protein kinase; FGF-inducible kinase; Polo-like kinase 3; PLK-3; Proliferation-related kinase; PLK3; CNK; FNK; PRK
 Product Gene Name   

anti-PLK3 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    602913
 3D Structure    ModBase 3D Structure for Q9H4B4
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Rat
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 Purity/Purification    Antigen Affinity Purified
 Form/Format    Liquid
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 Species    Human
 Immunogen    Recombinant human Serine/threonine-protein kinase PLK3 protein (C-160AA)
 Conjugate    Non-conjugated
 Buffer    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-9580 / sc-9578 / sc-25422
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-PLK3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-PLK3 antibody

   Serine/threonine-protein kinase involved in cell cycle regulation, response to stress and Golgi disassembly. Polo-like kinases act by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates ATF2, BCL2L1, CDC25A, CDC25C, CHEK2, HIF1A, JUN, p53/TP53, p73/TP73, PTEN, TOP2A and VRK1. Involved in cell cycle regulation: required for entry into S phase and cytokinesis. Phosphorylates BCL2L1, leading to regulate the G2 checkpoint and progression to cytokinesis during mitosis. Plays a key role in response to stress: rapidly activated upon stress stimulation, such as ionizing radiation, reactive oxygen species (ROS), hyperosmotic stress, UV irradiation and hypoxia. Involved in DNA damage response and G1/S transition checkpoint by phosphorylating CDC25A, p53/TP53 and p73/TP73. Phosphorylates p53/TP53 in response to reactive oxygen species (ROS), thereby promoting p53/TP53-mediated apoptosis. Phosphorylates CHEK2 in response to DNA damage, promoting the G2/M transition checkpoint. Phosphorylates the transcription factor p73/TP73 in response to DNA damage, leading to inhibit p73/TP73-mediated transcriptional activation and pro-apoptotic functions. Phosphorylates HIF1A and JUN is response to hypoxia. Phosphorylates ATF2 following hyperosmotic stress in corneal epithelium. Also involved in Golgi disassembly during the cell cycle: part of a MEK1/MAP2K1-dependent pathway that induces Golgi fragmentation during mitosis by mediating phosphorylation of VRK1. May participate in endomitotic cell cycle, a form of mitosis in which both karyokinesis and cytokinesis are interrupted and is a hallmark of megakaryocyte differentiation, via its interaction with CIB1.
 Applications Tested/Suitable for anti-PLK3 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

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 Western Blot (WB) of anti-PLK3 antibody    Western blot
All lanes: PLK3 antibody at 1.2ug/ml
Lane 1: Rat heart tissue
Lane 2: Hela whole cell lysate
Lane 3: 293T whole cell lysate
Lane 4: MCF7 whole cell lysate
Lane 5: Monocytic leukemia cells in mice Macrophages
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 72 kDa
Observed band size: 72 kDa

anti-PLK3 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-PLK3 antibody    Immunohistochemistry of paraffin-embedded human testis tissue using MBS7045722 at dilution 1:100
anti-PLK3 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-PLK3 antibody    Immunohistochemistry of paraffin-embedded human colon cancer using MBS7045722 at dilution 1:100
anti-PLK3 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for PLK3. It may not necessarily be applicable to this product.
 NCBI GI #    41872374
 NCBI GeneID    1263
 NCBI Accession #    NP_004064.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_004073.3 [Other Products]
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 UniProt Primary Accession #    Q9H4B4 [Other Products]
 UniProt Secondary Accession #    Q15767; Q5JR99; Q96CV1 [Other Products]
 UniProt Related Accession #    Q9H4B4 [Other Products]
 Molecular Weight    71,629 Da
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 NCBI Official Full Name    serine/threonine-protein kinase PLK3
 NCBI Official Synonym Full Names    polo like kinase 3
 NCBI Official Symbol    PLK3 [Similar Products]
 NCBI Official Synonym Symbols   
CNK; FNK; PRK; PLK-3
[Similar Products]
 NCBI Protein Information    serine/threonine-protein kinase PLK3
 UniProt Protein Name    Serine/threonine-protein kinase PLK3
 UniProt Synonym Protein Names   
Cytokine-inducible serine/threonine-protein kinase; FGF-inducible kinase; Polo-like kinase 3; PLK-3; Proliferation-related kinase
 Protein Family    Serine/threonine-protein kinase
 UniProt Gene Name    PLK3 [Similar Products]
 UniProt Synonym Gene Names    CNK; FNK; PRK; PLK-3 [Similar Products]
 UniProt Entry Name    PLK3_HUMAN
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 NCBI Summary for PLK3    The protein encoded by this gene is a member of the highly conserved polo-like kinase family of serine/threonine kinases. Members of this family are characterized by an amino-terminal kinase domain and a carboxy-terminal bipartite polo box domain that functions as a substrate-binding motif and a cellular localization signal. Polo-like kinases are important regulators of cell cycle progression. This gene has also been implicated in stress responses and double-strand break repair. In human cell lines, this protein is reported to associate with centrosomes in a microtubule-dependent manner, and during mitosis, the protein becomes localized to the mitotic apparatus. Expression of a kinase-defective mutant results in abnormal cell morphology caused by changes in microtubule dynamics and mitotic arrest followed by apoptosis. [provided by RefSeq, Sep 2015]
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 UniProt Comments for PLK3    PLK3: a kinase of the PLK family. Phosphorylated and activated following DNA damage or mitotic spindle disruption. Interacts with Chk2 and the interaction is enhanced upon DNA damage. Apparent substrates include Chk2 and p53. Plays an important role in regulating microtubule dynamics and centrosomal function. Deregulated expression of Plk3 results in cell cycle arrest and apoptosis.

Protein type: EC 2.7.11.21; Protein kinase, Ser/Thr (non-receptor); Protein kinase, Other; Nucleolus; Kinase, protein; Other group; PLK family

Chromosomal Location of Human Ortholog: 1p34.1

Cellular Component: centrosome; cytoplasm; Golgi stack; nucleolus; nucleoplasm; nucleus

Molecular Function: p53 binding; protein binding; protein serine/threonine kinase activity

Biological Process: apoptosis; cytoplasmic microtubule organization and biogenesis; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; endomitotic cell cycle; G1/S transition of mitotic cell cycle; G2/M transition of mitotic cell cycle; mitotic cell cycle checkpoint; negative regulation of apoptosis; negative regulation of transcription from RNA polymerase II promoter; protein kinase B signaling cascade; regulation of cell division; regulation of cytokinesis; response to DNA damage stimulus; response to osmotic stress; response to radiation; response to reactive oxygen species
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 Research Articles on PLK3    1. PLK3 predominantly is expressed in Cholangiocarcinomas (CCA) cells and that high PLK3 expression correlates with prolonged overall survival.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-PLK3 antibodyPathways associated with anti-PLK3 antibody
 Reference Product  PubMed Publications
 CDC25C antibody  >9 publications with PLK3 and CDC25C
 CHEK2 antibody  >5 publications with PLK3 and CHEK2
 CDC25A antibody  >4 publications with PLK3 and CDC25A
 CCNB1 antibody  >3 publications with PLK3 and CCNB1
 TP53 antibody  >2 publications with PLK3 and TP53
 CCNE1 antibody  >1 publications with PLK3 and CCNE1
 Products by Pathway  Pathway Diagram
 Direct P53 Effectors Pathway antibodies  Direct P53 Effectors Pathway Diagram
 FoxO Signaling Pathway antibodies  FoxO Signaling Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Generic Transcription Pathway antibodies  Generic Transcription Pathway Diagram
 Integrated Breast Cancer Pathway antibodies  Integrated Breast Cancer Pathway Diagram
 PLK3 Signaling Events Pathway antibodies  PLK3 Signaling Events Pathway Diagram
 Polo-like Kinase Signaling Events In The Cell Cycle Pathway antibodies  Polo-like Kinase Signaling Events In The Cell Cycle Pathway Diagram
 Regulation Of TP53 Activity Pathway antibodies  Regulation Of TP53 Activity Pathway Diagram
 Regulation Of TP53 Activity Through Phosphorylation Pathway antibodies  Regulation Of TP53 Activity Through Phosphorylation Pathway Diagram
 TP53 Regulates Transcription Of Cell Cycle Genes Pathway antibodies  TP53 Regulates Transcription Of Cell Cycle Genes Pathway Diagram
Diseases associated with anti-PLK3 antibodyOrgans/Tissues associated with anti-PLK3 antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >9 publications with PLK3 and Nervous System Diseases
 Breast Neoplasms Antibodies  >8 publications with PLK3 and Breast Neoplasms
 Adenocarcinoma Antibodies  >7 publications with PLK3 and Adenocarcinoma
 Disease Models, Animal Antibodies  >6 publications with PLK3 and Disease Models, Animal
 Lung Diseases Antibodies  >5 publications with PLK3 and Lung Diseases
 Cardiovascular Diseases Antibodies  >5 publications with PLK3 and Cardiovascular Diseases
 Necrosis Antibodies  >5 publications with PLK3 and Necrosis
 Lung Neoplasms Antibodies  >4 publications with PLK3 and Lung Neoplasms
 Liver Diseases Antibodies  >4 publications with PLK3 and Liver Diseases
 Cell Transformation, Neoplastic Antibodies  >4 publications with PLK3 and Cell Transformation, Neoplastic
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >16 publications with PLK3 and Blood
 Brain Antibodies  >15 publications with PLK3 and Brain
 Eye Antibodies  >9 publications with PLK3 and Eye
 Bone Antibodies  >8 publications with PLK3 and Bone
 Lung Antibodies  >6 publications with PLK3 and Lung
 Bone Marrow Antibodies  >4 publications with PLK3 and Bone Marrow
 Muscle Antibodies  >3 publications with PLK3 and Muscle
 Skin Antibodies  >2 publications with PLK3 and Skin
 Thymus Antibodies  >2 publications with PLK3 and Thymus
 Ovary Antibodies  >1 publications with PLK3 and Ovary
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